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A prospective randomized trial shows trabeculotomy is noninferior to combined trabeculotomy-trabeculectomy for 3-year control of intraocular pressure in primary congenital glaucoma with corneal diameter 12-14 mm, providing a less invasive s
This study identifies pediatric age, supratubal recess involvement, mastoid extension, and surgical technique as independent predictors of cholesteatoma recidivism, highlighting the need for tailored postoperative surveillance strategies.
This population-based study reveals significant differences in pathological response and survival outcomes between stage III melanoma patients with lymph node metastases and those with in-transit metastases treated with neoadjuvant PD-1 inh
This review synthesizes evidence from a rigorously conducted RCT demonstrating the efficacy and safety of nightly baclofen vaginal suppositories for chronic pelvic pain due to pelvic floor muscle dysfunction, highlighting therapeutic advanc
The AASLD EXPO gives timely, consensus-driven guidance: screen all HBsAg-positive persons once for anti-HDV, confirm viremia with HDV RNA, stage with elastography, and treat compensated chronic HDV with bulevirtide (± peg‑IFN) while monitor
This study reveals that LATE-NC, a common neuropathology in aging, is linked to cognitive impairment and coexisting brain lesions in a diverse Brazilian population, underscoring its significance beyond homogenous cohorts.
This article explores how common genetic variants near SLC2A2 affect glycemic response to glimepiride in type 2 diabetes, highlighting potential for precision medicine in second-line diabetes therapy.
The ENCIRCLE trial reports sustained mitral regurgitation reduction, improved functional status, and manageable safety outcomes at 2 years after percutaneous transseptal TMVR using the SAPIEN M3 system in high-risk symptomatic MR patients.
This article examines significant improvements in underrepresented racial and ethnic minority representation among oncology trainees post-2020, highlighting progress and ongoing disparities in the oncology workforce.
A 12-month multicenter RCT shows that a single intra-articular injection of 25 million autologous adipose-derived stromal vascular fraction cells significantly improves pain and function in moderate-to-severe knee osteoarthritis compared wi
This study assesses health and care satisfaction outcomes in younger disabled adults enrolled in a Program of All-Inclusive Care for the Elderly (PACE), highlighting functional and community engagement trends, satisfaction, and healthcare u
This cluster-randomized trial demonstrates that biannual topical 38% silver diamine fluoride is noninferior to atraumatic restorative treatments for arresting and preventing dental caries in older adults, providing a simple, effective strat
Retatrutide, a triple agonist targeting GIP, GLP-1, and glucagon receptors, demonstrates marked weight loss and improvement in knee osteoarthritis pain and obstructive sleep apnea in adults with obesity in a phase 3 trial.
Immersive virtual reality-based naming therapy significantly improves language function, quality of life, and patient engagement in chronic post-stroke aphasia compared to conventional therapy.
Shotgun metagenomic sequencing reveals significant taxonomic and functional shifts in the salivary microbiome, correlating with stages of periodontal disease, highlighting potential biomarkers for early detection and risk stratification.
This review synthesizes evidence from the Prepare for Kidney Care trial and complementary studies, highlighting that in older frail or multimorbid kidney failure patients, responsive management offers similar quality-adjusted life expectanc
A 2023 fatwa by the Minnesota Islamic Council endorses pasteurized donor human milk when a mother’s milk is unavailable. This article summarizes the religious clarification, aligns it with clinical guidance, and offers practical steps
Musculoskeletal disorders are the leading cause of disability and productivity loss globally in working-age populations, with a projected 24% rise in burden by 2050, predominantly affecting high-income countries and driven by obesity and er
Using organs from Trypanosoma cruzi-positive donors expands transplant availability in endemic regions but necessitates vigilant monitoring to manage Chagas disease reactivation safely.
A phase 1 study demonstrates that low-dose intralesional cemiplimab is safe and achieves high complete response rates in early-stage cutaneous squamous cell carcinoma, supporting further clinical exploration.
