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Astegolimab, an anti-ST2 monoclonal antibody, significantly reduced moderate/severe exacerbations in COPD patients with frequent exacerbations in pooled ALIENTO and ARNASA analyses, showing promise for targeting the IL-33/ST2 pathway with g
Emerging evidence links high pesticide exposure events (HPEEs) in farmers to increased self-reported olfactory dysfunction, though objective smell testing yields inconclusive associations, highlighting critical gaps and methodological consi
This review synthesizes evidence on IL-16-driven resistance to BTK inhibitors and chemoimmunotherapy in B-cell lymphomas, highlighting the IL-16/CD9/PI3K axis as a targetable epigenetically regulated survival pathway overcoming drug resista
Vulvar cancer exhibits significant recurrence rates, predominantly local, with survival declining sharply after recurrence. Awareness of recurrence-associated symptoms enhances early detection. Surgery remains pivotal in management, with fr
This review explores evidence linking smoking and exhaled carbon monoxide levels to reduced Parkinson’s disease risk, emphasizing a potential protective role of carbon monoxide, supported by recent large-scale cohort data and biologic
This review examines the role of FreeStyle Libre Pro iQ CGM in differentiating presymptomatic stages of type 1 diabetes and predicting progression to clinical disease, comparing its performance with Dexcom G6 and discussing implications for
This review synthesizes evidence linking aspirin use to reduced risk of calcific aortic valve disease in persons with elevated lipoprotein(a), highlighting the potential for targeted preventive strategies.
Macrotroponin complexes commonly cause discordant cardiac troponin elevations in the general population, notably troponin I, without conferring increased cardiovascular risk, underscoring the need to recognize assay interference for accurat
This review synthesizes emerging evidence demonstrating robust effectiveness of RSV vaccination in reducing hospitalization, death, and severe outcomes among elderly nursing home residents during the vaccine’s inaugural season.
This review synthesizes current evidence on the impact of continuing psychostimulant treatment during pregnancy on postpartum mental health outcomes among people with ADHD, highlighting key findings and clinical implications from recent lar
Secondary analysis of the TASTE trial reveals tenecteplase confers superior functional outcomes versus alteplase in patients with distal middle cerebral artery occlusions, supporting its use in more peripheral ischemic stroke territories.
Aficamten, a cardiac myosin inhibitor, demonstrated significant improvements in symptoms, diastolic function, and biomarkers in nonobstructive hypertrophic cardiomyopathy across multiple trials, including the pivotal ACACIA-HCM study.
This review synthesizes evidence linking cumulative atopic diseases—including asthma, atopic dermatitis, and allergic rhinitis—to keratoconus risk, highlighting a dose-dependent association and the role of healthcare utilization in case asc
This review synthesizes recent evidence on event-based progression detection in glaucoma, highlighting that OCTA vessel density may identify progression earlier than structural OCT or visual field testing, with important implications for cl
This review synthesizes longitudinal evidence on 3D eye shape remodeling in high myopia, linking distinct morphologic trajectories to sight-threatening outcomes and supporting individualized risk stratification beyond axial length alone.
Accumulating evidence underscores how adverse social determinants of health (SDOH) from early adulthood heighten the risk of early-onset stroke, with dose-dependent effects and disparities by race and sex.
Pregnancy significantly reduces antiseizure medication concentrations, with lamotrigine showing the greatest decline. Polytherapy and body weight modulate these changes, underscoring the importance of individualized therapeutic drug monitor
This review synthesizes evidence from the TEASE-1 trial and related studies on gildeuretinol acetate, highlighting its safety profile and modest efficacy in slowing retinal atrophic lesion growth in Stargardt disease over 24 months.
This review examines the development, efficacy, and safety of combined oral contraceptives (COCs), highlighting the emergence of natural-estrogen-containing formulations and their role in optimizing contraceptive care.
This review examines the clinical relevance of a ≥30% decrease in VCTE-derived liver stiffness in predicting fibrosis regression in MASH, highlighting modest predictive accuracy and the need for improved biomarkers.
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