Section
The 2024 McDonald criteria revisions enable earlier MS diagnosis in many patients with radiologically isolated syndrome (RIS), potentially altering management before clinical symptoms arise, according to a large multicenter Italian study.
Persistent severe vitamin D deficiency during adolescence in girls with idiopathic scoliosis is linked to poorer bone mineral density and compromised bone structure into early adulthood, highlighting the need for targeted interventions.
The BioTAK score, a novel biomarker-driven diagnostic tool, accurately discriminates Takotsubo syndrome from acute coronary syndrome pre-angiography, streamlining diagnostic pathways and potentially reducing invasive procedures.
This comprehensive review synthesizes emerging evidence supporting a new TNM staging system tailored for poorly differentiated thyroid cancer, demonstrating enhanced prognostic accuracy over existing differentiated thyroid cancer models.
Acetabular rim microfracture during hip labral reconstruction significantly improves graft vascularization, integration, and fibrocartilaginous remodeling, suggesting a promising biological augmentation strategy.
Undernutrition after dysvascular major lower limb amputation is linked to higher rates of reamputation or mortality, reduced mobility, and poorer quality of life, emphasizing the need for targeted nutritional interventions.
This study uses causal machine learning to reveal that tooth extraction before radiotherapy neither universally reduces nor increases osteoradionecrosis risk, but individualized effects vary substantially, underscoring the need for patient-
A large UK randomized trial found that routine outpatient CT coronary angiography after ruling out myocardial infarction in suspected acute coronary syndrome did not reduce the risk of subsequent cardiac events compared to standard care.
This qualitative study explores how patients with Parkinson’s disease experience and perceive pain, revealing its complex impact on daily life and emotional well-being, underscoring the need for holistic pain management strategies.
A clinical trial comparing piezosurgery and rotary burs in aesthetic crown lengthening found no significant difference in gingival margin stability, with most changes occurring within the first week post-surgery and stability achieved by si
Ruzaltatug rezetecan, a HER3-directed antibody-drug conjugate, significantly improves progression-free survival over chemotherapy with manageable safety in EGFR-mutated advanced NSCLC progressing after EGFR TKI therapy.
This study evaluates how low levels of pyuria influence antibiotic prescribing in children with suspected urinary tract infections (UTIs), revealing that minor pyuria often leads to unnecessary antibiotic use.
This exploratory study evaluates the safety and efficacy of blinatumomab in treating dermatomyositis and refractory ANCA-associated vasculitis, revealing promising immunological and clinical improvements without serious adverse events over
Living donor transplantation demonstrates overall positive mental health outcomes but reveals high-risk subgroups necessitating improved psychosocial assessments and tailored follow-up care to optimize donor wellbeing.
Ruxolitinib cream demonstrates sustained safety and effective disease control over 52 weeks in children aged 2 to 11 years with mild-to-moderate atopic dermatitis, affirming its role as a promising therapeutic option.
This study demonstrates that retrorectus placement of absorbable polyglactin mesh significantly reduces bulge incidence after DIEP flap harvest, with a novel nomogram to personalize hernia risk and guide surgical decisions.
A comprehensive 15-year population-based study in Catalonia reveals that over 40% of sepsis survivors die within two years post-discharge, highlighting significant impacts of age, comorbidities, and hospital stay duration on long-term outco
This pilot study assesses the use of virtual reality as a feasible and acceptable non-pharmacologic adjunct to alleviate pain during vaso-occlusive episodes in adults with sickle cell disease.
This study reveals that the viral RNA sensor RIG-I in platelets modulates thrombotic responses during influenza infection, limiting thrombosis and facilitating immune cell transmigration through a unique signaling pathway.
A novel Pre-COPD score, integrating smoking history, symptoms, asthma, and spirometry, robustly predicts incident COPD across three multinational cohorts, enabling early risk stratification and preventive strategies in clinical practice.
