Emerging evidence demonstrates that ligature-induced periodontitis can promote clonal hematopoiesis driven by Dnmt3a mutations, linking oral inflammation to hematopoietic dynamics.
Chronic inflammation from periodontitis may facilitate a pro-metastatic microenvironment in solid tumors through hematopoietic-mediated systemic effects.
Integrating periodontitis status and clonal hematopoiesis biomarkers in clinical trial design could enhance understanding of tumor progression and response to therapy.
Microbiome alterations associated with periodontitis modulate host immune and hematopoietic compartments, highlighting novel translational and therapeutic avenues.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.