Bridging Periodontitis and Clonal Hematopoiesis: Implications for Solid Tumor Metastasis, Clinical Trial Design, and Microbiome Dynamics

Highlights

• Emerging evidence demonstrates that ligature-induced periodontitis can promote clonal hematopoiesis driven by Dnmt3a mutations, linking oral inflammation to hematopoietic dynamics.
• Chronic inflammation from periodontitis may facilitate a pro-metastatic microenvironment in solid tumors through hematopoietic-mediated systemic effects.
• Integrating periodontitis status and clonal hematopoiesis biomarkers in clinical trial design could enhance understanding of tumor progression and response to therapy.
• Microbiome alterations associated with periodontitis modulate host immune and hematopoietic compartments, highlighting novel translational and therapeutic avenues.

Background