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The ASPIRED trial showed that 14-day ambulatory ECG monitoring after unexplained syncope in the emergency department did not significantly reduce syncope recurrence compared to standard care over one year.
This 18-month double-blind randomized trial compared one-shade and multi-shade flowable composites for restoring non-carious cervical lesions, demonstrating comparable clinical performance and objective color match, with multi-shade composi
This review details the phase 3 PANKU-Breast01 trial evaluating izalontamab brengitecan versus chemotherapy in pretreated HR+/HER2- breast cancer, highlighting significant PFS improvement and safety considerations in a Chinese cohort.
This article reviews a cohort study characterizing the clinical features, complications, and developmental challenges in children with Zika-related microcephaly during the first five years after birth, highlighting the severity and scope of
This study evaluates the six-month effectiveness and long-term retention of TNF, IL-17, and IL-23 inhibitors in psoriatic arthritis, revealing comparable efficacy and persistence across biologic classes and highlighting disease duration as
MASLD has become a leading cause of liver transplantation in the US, with increasing transplant volumes and younger recipients. Despite relative stabilization in growth, survival post-transplant has improved, highlighting evolving epidemiol
This study examines 417 retroauricular interpolated flap repairs after Mohs surgery, identifying stage-specific complication rates and risk factors such as diabetes and defect size to inform surgical risk management.
A novel anatomical classification system from Texas Children’s Hospital aids in assessing conjoined twin separation feasibility, guiding surgical planning, and improving outcomes through structured reconstruction strategies.
This article details the implementation and clinical outcomes of the Unbroken Integrative Psycho-Trauma Care Model, a coordinated multidisciplinary approach delivering trauma-informed mental health care at scale within a civilian hospital s
A validated clinical model predicting survival after pediatric extracorporeal cardiopulmonary resuscitation reveals significant inter-hospital outcome variability, underscoring the importance of risk-standardized benchmarking in pediatric i
This study validates plasma biomarkers GFAP and UCH-L1 as sensitive but nonspecific tools to help rule out intracranial injury in mild traumatic brain injury patients, potentially improving emergency department efficiency while highlighting
This qualitative study explores how pain self-management interventions can be specifically tailored for patients with co-occurring chronic pain and opioid use disorder, addressing barriers and facilitators identified by patients and clinici
This article explores how CD7 CAR-T therapy leads to EBV-positive lymphoproliferative disorder by revealing CD7-negative T cell dysfunction, immunosuppressive macrophage niches, and EBV-driven B cell transformation through multi-omic techno
This article explores how AI could transform critical care by illustrating potential benefits, harms, and ethical challenges through ten parables, guiding clinicians and policymakers in preparing for AI’s integration amid uncertainty.
Sustained VEGF-A suppression via the Port Delivery System with ranibizumab effectively resolves diabetic macular edema with most patients achieving edema normalization; slow resolution may mimic treatment unresponsiveness, warranting reclas
This study highlights how social vulnerability correlates with higher asthma comorbidity and increased surgical intervention rates in children with obstructive sleep apnea, revealing disparities in disease severity and care pathways.
This study develops and prospectively validates a simple endoscopic classification of fundoplication integrity that reliably predicts pathological gastroesophageal reflux post-antireflux surgery, correlating with functional and clinical out
Discontinuation of antidepressants during pregnancy is common and linked to increased mental health-related emergency visits, underscoring the need for supportive treatment strategies for perinatal mental health.
Analysis of 1,983 high-certainty DILI cases over two decades reveals shifting drug causes, declining severity, increased herbal and oncology-related cases, and higher mortality among elderly, patients with chronic liver disease, and oncolog
A nested case-control study from the UK Biobank reveals that living near water pollutant-emitting industrial facilities increases the risk of developing progressive supranuclear palsy, with risk influenced by pollutant type, distance, and d
