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Thyroid Cancer Treatment in Adolescents and Young Adult Women: Impact on Reproductive Outcomes in a Population-Based Cohort
Thyroid cancer treatments in young women are linked to increased infertility diagnosis and early menopause but show no significant association with premature ovarian insufficiency or reduced childbirth rates.
Long COVID-19 in Pregnancy: Elevated Risk Amidst Mild Omicron Infection in a Boosted Vaccinated Cohort During COVID-19 Endemicity
Pregnant women show increased risk of long COVID-19 post-SARS-CoV-2 infection during Omicron predominance despite mild disease, yet incidence remains modest in a highly vaccinated cohort, highlighting vaccination’s protective role amidst em
The Role of COVID-19 Vaccination in Improving Maternal and Perinatal Outcomes: A Comprehensive Review
Vaccination against SARS-CoV-2 during pregnancy significantly lowers risks of severe maternal COVID-19, hospitalization, critical care admission, and preterm birth across variant periods, underscoring its safety and efficacy for maternal an
Tailored Weight Loss Interventions in Serious Mental Illness: A Comprehensive Review of Evidence and Clinical Implications
This review synthesizes evidence on tailored weight loss programs for adults with serious mental illness, highlighting recent advances, effectiveness, mechanistic insights, and future directions.
Tailored Weight Loss Interventions for Veterans with Serious Mental Illness: Efficacy and Implementation Insights from Recent RCT Evidence
This review synthesizes evidence from a 2025 randomized clinical trial evaluating a tailored weight loss program, CoachToFit, for veterans with serious mental illness, highlighting its potential to improve weight outcomes via remote support
Causal Insights Into Hidradenitis Suppurativa: Mendelian Randomization Evidence Linking BMI, Inflammatory Bowel Disease, and Smoking
Recent Mendelian randomization analyses demonstrate causal effects of increased BMI and inflammatory bowel disease on hidradenitis suppurativa risk, elucidating modifiable contributions beyond genetic correlations with psoriasis and systemi
Efficacy of mHealth Interventions for Smoking Cessation in Tuberculosis Patients: Insights from a Cluster Randomized Clinical Trial
An mHealth text messaging intervention significantly improves smoking cessation rates and reduces mortality among TB patients compared to usual care, supporting its implementation in TB programs.
Benchmarking Global Progress in Non-Communicable Diseases: A Comprehensive Analysis of Cause-Specific Mortality Trends from 2001 to 2019
From 2010 to 2019, NCD mortality declined in 80% of countries worldwide, driven primarily by reductions in circulatory diseases, with notable regional and cause-specific heterogeneity and slower progress than the previous decade.
Diabetes, Obesity, and Early Rhythm Control in Atrial Fibrillation: Insights from the EAST-AFNET 4 Trial
This analysis of the EAST-AFNET 4 trial highlights that early rhythm control therapy’s cardiovascular benefits and safety are consistent regardless of diabetes or obesity status in atrial fibrillation patients.
Digital Cognitive Behavioral Therapy for Generalized Anxiety Disorder: Evidence, Impact, and Future Directions
Recent robust randomized trials demonstrate that smartphone-delivered digital cognitive behavioral therapy provides significant, sustained improvements in generalized anxiety disorder, overcoming key access barriers and highlighting its pot
Ticagrelor Plus Aspirin Versus Aspirin Alone After Coronary Artery Bypass Grafting in Acute Coronary Syndrome: A Contemporary Evidence Synthesis
This review synthesizes current evidence on the efficacy and safety of ticagrelor combined with aspirin compared to aspirin alone following CABG for acute coronary syndrome, highlighting the 2025 TACSI trial and its implications for clinica
Calcium Supplementation During Pregnancy for Preventing Hypertensive Disorders: Current Evidence and Clinical Implications
This review synthesizes recent randomized controlled trials and meta-analyses on calcium supplementation during pregnancy, evaluating its effectiveness in preventing hypertensive disorders such as pre-eclampsia and related maternal and neon
Manual Therapy Combined with Exercise for Neck Pain: An Evidence-Based Clinical Update
Systematic review evidence suggests manual therapy with exercise moderately improves function and reduces pain in chronic neck pain compared with no treatment; benefits versus placebo are less clear, highlighting need for further trials and
Enhancing Access to Mifepristone via Community Pharmacies: Evidence from Routine Prescription Regulation in British Columbia, Canada
This review synthesizes data on mifepristone availability at community pharmacies in BC, highlighting geographic coverage, dispensing gaps, and disparities influencing timely access to medication abortion.
Planetary Health Diet and Cardiometabolic Risk Reduction in Women with Gestational Diabetes: An Evidence-Based Review
This review synthesizes evidence linking adherence to the Planetary Health Diet with reduced risks of myocardial infarction, type 2 diabetes, and improved weight management in women post-gestational diabetes, highlighting BMI’s mediating ro
Proton Pump Inhibitor Use and Survival Outcomes in Newly Diagnosed Glioblastoma: An Evidence-Based Review
Proton pump inhibitor use, particularly potent ALDH1A1-activating PPIs, is associated with worse survival in newly diagnosed glioblastoma, highlighting the need for cautious use and further mechanistic research.
Reevaluating the Link Between Household Air Pollution from Biomass Cooking and Severe Pneumonia in Infants: A Comprehensive Evidence Synthesis
Recent high-quality studies challenge the presumed association between household air pollution from biomass cooking and severe infant pneumonia, highlighting inconsistent exposure-response relationships for PM2.5 and CO.
Development and Validation of an Interpretable Hybrid Machine Learning Model for Predicting Long-term Lung Transplant Outcomes
This review synthesizes evidence on a novel hybrid machine learning model leveraging US lung transplant registry data to predict mortality or retransplant risk at 1, 5, and 10 years, highlighting its clinical utility and balanced interpreta
Connectivity as a Universal Predictor of Tau Progression in Atypical Alzheimer’s Disease: A Multicentre Evidence Synthesis
Functional connectivity reliably predicts spatial and temporal tau propagation patterns across atypical Alzheimer’s disease variants, underpinning personalized approaches to diagnosis and therapy.
Risk and Outcomes of Secondary Cancer Among Lung Cancer Survivors After Definitive Treatment: A Comprehensive Review
This review synthesizes evidence on the incidence, risk factors, and outcomes of secondary cancers in non-small cell lung cancer survivors post-definitive therapy, highlighting genetic predisposition as a key determinant distinct from recur
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