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A large-scale analysis estimates the U.S. national burden of severe hemolytic disease of the fetus and newborn (HDFN) caused by anti-D, anti-K, and anti-c alloantibodies, revealing that severe HDFN is rare despite common alloimmunization.
A pivotal Phase 2 study demonstrates that derazantinib yields meaningful responses and progression-free survival in FGFR2-aberrant advanced intrahepatic cholangiocarcinoma, with an acceptable safety profile, supporting its role as a targete
Gain-of-function variants in PLAAT4 define a novel autosomal dominant leukodystrophy characterized by spastic paraplegia and spinal cord white matter abnormalities, with arachidonic acid-related lipids as potential biomarkers.
Acmopatide, a novel biased GLP-1/GIP receptor agonist, improves glycemic control and reduces body weight without severe adverse events in overweight adults with type 1 diabetes, based on a 16-week phase 2 randomized trial.
This multicenter study reveals that among HLHS subtypes, mitral stenosis and aortic atresia with ventriculocoronary connections have the poorest transplant-free survival, highlighting the prognostic importance of prenatal and postnatal VCC
A multicenter RCT demonstrates that a standardized clinical pathway for platelet-rich plasma therapy improves 12-month pain and function outcomes with fewer adverse events in early knee osteoarthritis compared to conventional care.
This study explores diverse stakeholder views on oral health needs and care for dependent older adults, highlighting the importance of subjective outcomes like comfort and function often overlooked in service provision and research.
This phase 3 trial shows that tarlatamab combined with durvalumab significantly improves overall and progression-free survival compared to durvalumab alone as maintenance therapy post-first-line chemoimmunotherapy in extensive-stage small-c
Regular exercise in midlife women moderates age-related cognitive decline, particularly in processing speed and demanding working memory tasks, with resistance training showing unique benefits for reaction time.
This qualitative study reveals empowerment as central to promoting safer mobility in Parkinson’s disease, emphasizing individualized, contextual, and collaborative strategies for fall prevention.
Eating difficulty is associated with broader functional vulnerability and cognitive decline, rather than directly triggering dementia, highlighting its importance in comprehensive geriatric assessment beyond dental health screening.
The PANKU-Lung01 phase 3 trial demonstrates izalontamab brengitecan significantly extends progression-free survival compared to platinum-based chemotherapy in EGFR-mutated advanced non-squamous NSCLC after failure of third-generation EGFR T
This study tracks executive function trajectories from age 2 to 13 in very preterm children, revealing enduring difficulties compared to full-term peers and highlighting the need for early and ongoing interventions, particularly accounting
This study identifies a CCL20+ macrophage subpopulation as a major source of TNF in axial spondyloarthritis synovium, driven by CD40L and an IL-1β/TNF-α autocrine loop, providing insights into disease pathogenesis and therapeutic targets.
Combining serum leucine-rich alpha-2-glycoprotein 1 (LRG-1) with citrulline offers a sensitive, noninvasive biomarker strategy for early detection and monitoring of rejection in intestinal transplantation, potentially reducing reliance on i
This retrospective study evaluates the incidence and risk factors for infantile hemangioma ulceration following oral propranolol therapy, highlighting subtype-related risks and anatomical protective factors to guide clinical management.
In a randomized trial, sodium citrate as an anticoagulant in concentrated growth factor therapy for androgenetic alopecia reduced injection pain, improved hair density, and increased patient satisfaction compared with heparin sodium or no a
Sepsis triggers mitochondrial impairment in platelets, promoting hyperactivation via ROS production. The mitochondria-specific antioxidant MitoTEMPO reverses these changes in vitro, suggesting therapeutic potential to prevent sepsis-related
Cardiovascular risk prediction models show limited accuracy in postmenopausal women with chronic kidney disease, often underestimating risk, highlighting the need for improved tools in this high-risk population.
This nationwide study reveals that donor cell-derived hematologic neoplasms (DDHN) after allogeneic stem cell transplantation are rare but linked mainly to inherited germline mutations in related donors, underscoring the need for comprehens
