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A new ex vivo human myometrium study suggests that lower-dose nifedipine-based combinations may produce synergistic tocolysis, supporting a translational path toward safer short-term suppression of preterm labor.
This clinical update reviews a new randomized crossover trial and prior literature showing that high-intensity interval exercise can attenuate glucose decline and late hypoglycaemia in adults with type 1 diabetes, particularly when performe
REIMAGINE 1 shows that once-weekly CagriSema significantly reduced HbA1c and bodyweight versus placebo in early type 2 diabetes, with mainly gastrointestinal adverse events and a mechanistically compelling incretin–amylin profile.
The 2024 ESC-endorsed RF-CL model improves estimation of obstructive CAD probability in symptomatic patients, safely reducing unnecessary testing, but symptom ambiguity, qualitative upper ranges, and limited capture of ischemia without obst
A major 2026 cluster randomized trial shows that palliative care delivered by trained hepatologists is noninferior to specialist palliative care for improving quality of life in end-stage liver disease, supporting scalable integrated models
A large EBMT registry study suggests that escalating fludarabine during lymphodepletion does not improve tisagenlecleucel outcomes in LBCL and may worsen survival, while axicabtagene ciloleucel retains superior efficacy at standard dosing b
A new Blood study links relapse after myeloma ASCT to CSF-1R+ immunosuppressive marrow macrophages and shows that CSF-1R inhibition synergizes with lenalidomide in preclinical models, providing a strong translational rationale for post-tran
A new cohort study suggests ultra-widefield fluorescein angiography frequently detects persistent peripheral leakage in clinically inactive demyelinating disease-associated uveitis, highlighting a potential gap between examination-based rem
A new prospective cohort study suggests that retinal nerve fiber layer thickness on neonatal OCT at 36 weeks’ PMA may help predict 2-year motor and cognitive outcomes in very preterm infants.
An early single-institution series suggests histotripsy may offer noninvasive local control for neuroendocrine liver metastases, with complete response after full-coverage treatment but important safety concerns, particularly acute kidney i
This review synthesizes the American Thoracic Society’s 2026 research statement on the US Air Quality Index, identifying critical knowledge gaps and prioritizing five research domains to enhance its effectiveness for patients with res
This review synthesizes findings from the Bridge to HOPE multicenter trial and other recent evidence, demonstrating that portal-venous hypothermic oxygenated perfusion (HOPE) significantly reduces early allograft dysfunction, improves bilia
A large-scale Dutch cohort study reveals that women with a history of spontaneous preterm birth face a significantly elevated risk of cardiovascular mortality, with the highest risk observed in those delivering before 32 weeks of gestation.
This review analyzes significant inter-hospital variations in opioid prescribing for vaginal births with complications, highlighting the need for standardized postdischarge pain management protocols to reduce unnecessary opioid exposure.
This review explores how tumour-infiltrating adipocytes release 12,13-DiHOME to trigger neutrophil ferroptosis and CXCL2 production, ultimately subverting CD8+ T cell-mediated immunity in pancreatic ductal adenocarcinoma.
Recent high-quality randomized clinical trials and meta-analyses suggest that routine magnesium sulfate infusion does not effectively prevent postoperative atrial fibrillation in cardiac surgery, especially when used alongside standard beta
This review synthesizes recent evidence on concurrent endometrial carcinoma risk in atypical hyperplasia, highlighting significant disparities in minority populations, the protective role of adenomyosis, and the emergence of GLP-1 receptor
This review synthesizes findings from a large-scale cohort study comparing laparoscopic and abdominal hysterectomy, highlighting significant surgical advantages for laparoscopy despite complex survival data.
This review explores the association between maternal anti-HLA antibodies and fetal growth restriction (FGR), synthesizing evidence that suggests an alloimmune mechanism may contribute to placental dysfunction and restricted fetal developme
This review synthesizes clinical evidence for Belapectin, a Galectin-3 inhibitor, focusing on its ability to prevent esophageal varices in patients with MASH cirrhosis and portal hypertension as demonstrated in the NAVIGATE trial.
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