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This study introduces a novel classification framework for systemic sclerosis based on vascular and fibrotic complications, identifying a high-risk mixed endotype with distinct immunologic features and prognostic relevance, offering improve
A novel three-dimensional scanning workflow accurately predicts tissue expansion progress, optimizing surgical timing and improving reconstructive outcomes for congenital melanocytic nevus patients.
Mindfulness-Oriented Recovery Enhancement (MORE) modulates prefrontal cortical activity, reduces craving, and prolongs abstinence in opioid use disorder by rebalancing neural responses to drug and natural rewards, substantiating its role as
Delayed appropriate antifungal therapy after the onset of persistent hypotension dramatically increases mortality in Candida septic shock; survival drastically improves with treatment within 2 hours.
AI scribes reduce active documentation time among emergency physicians, delay note initiation without prolonging completion, and yield longer notes without increasing short-term readmissions, supporting efficient clinical documentation acro
This study quantifies hospital discharge communication preferences among patients with non-English language preferences, highlighting the importance of language-concordant instructions and family involvement to improve transitional care.
2′-FL supplementation post-allo-HSCT preserves gut microbiome diversity, enriches beneficial taxa, reduces acute GI GVHD and viral reactivation, demonstrating safety and translational potential in pediatric transplant care.
The POWER trial assessed a self-directed lifestyle program for patients with OSA and obesity, finding modest improvements in sleep-related quality of life but limited clinically meaningful weight loss over 12 months.
Tamoxifen-related retinal toxicity is known but ophthalmic evaluations after initiation are infrequent. Recent data reveal low screening rates, rare retinal-specific testing, and no greater ophthalmic use than aromatase inhibitors. Emerging
Vestibular migraine patients show impaired auditory temporal resolution despite normal hearing, highlighting central auditory processing involvement and suggesting potential for targeted auditory rehabilitation.
Significant variation exists in medical debt incurred by trauma patients depending on the hospital of treatment, highlighting modifiable factors in billing and financial practices that could mitigate financial hardship.
Analysis of anti-müllerian hormone (AMH) trajectories reveals two distinct decline patterns across menopause, with slower AMH decline linked to higher postmenopausal cardiovascular risk, independent of premenopausal risk factors.
This study reveals that elevated transglutaminase 2 activity from intestinal myofibroblasts drives fibrosis independent of inflammation in stricturing Crohn’s disease and that inhibiting TG2 can reduce fibrotic ECM accumulation, suggesting
Arterial spin labeling MRI enables reliable, noninvasive exclusion of arteriovenous shunts in intracerebral hemorrhage, potentially reducing reliance on invasive digital subtraction angiography.
This meta-analysis synthesizes prospective data on sunitinib treatment in metastatic pheochromocytomas and paragangliomas, revealing modest response rates and meaningful disease control with manageable safety profiles.
Consistent resistance training combined with recommended aerobic activity and low sedentary television viewing substantially reduces major cardiovascular events risk in women, particularly myocardial infarction.
The R-ALPS randomized trial confirms that benmelstobart improves progression-free survival in unresectable stage III NSCLC patients post-chemoradiotherapy, while adding anlotinib does not significantly enhance efficacy and raises severe tox
This study reveals that increased pitch counts relative to individual averages and reductions in fastball velocity are significantly associated with higher risks of shoulder and elbow injuries among collegiate baseball pitchers during a sum
A novel robotic tool, SomatoCircleJump, demonstrates reliable and sensitive detection of thumb proprioception impairments in chronic stroke survivors, revealing higher prevalence and close relation to finger deficits compared to traditional
A machine learning model using common blood tests, age, sex, and smoking status moderately distinguishes severe from mild periodontitis, highlighting potential but necessitating further validation before clinical use.
