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Healthcare professionals face significant gaps in cardiovascular prevention despite their critical role in care. The ESC Congress 2025 revealed prevalent modifiable risks, underuse of therapies, and subclinical atherosclerosis, underscoring
The HELIOS-B trial showed vutrisiran improves survival and cardiac outcomes in transthyretin amyloidosis with cardiomyopathy, with consistent benefits regardless of baseline tafamidis use, supporting further evaluation of combination therap
The NOTION-4 trial demonstrates that 3 months of DOAC therapy post-TAVR reduces early HALT incidence compared to SAPT, but benefits diminish after discontinuation, highlighting nuanced balance between thrombosis prevention and bleeding risk
A nurse-led, mobile health-supported collaborative care intervention significantly increased days alive and out of hospital and reduced mortality among Indian patients with heart failure with reduced ejection fraction over 2 years.
Elevated lipoprotein(a) confers a consistent relative risk increase for atherosclerotic cardiovascular disease across all adult ages, with absolute risks rising substantially in older adults.
This study shows that the choice of cannulation site—femoral versus axillary—does not independently affect early mortality or neurological complications after acute type A aortic dissection repair; instead, timely systemic reperfusion and c
The RNF213 p.R4810K variant independently increases risk and severity of extracranial carotid artery disease, distinct from its known association with intracranial atherosclerosis, highlighting new insights into vascular disease genetics an
A novel deep learning algorithm accurately detects moderate or greater aortic stenosis using AI-guided focused cardiac ultrasound acquired by novice operators, presenting a scalable solution to expand screening accessibility.
A novel machine learning-based model demonstrates improved risk prediction in transthyretin amyloid cardiomyopathy, surpassing traditional staging systems and supporting personalized patient management.
The PROFID study reveals a declining mortality benefit from primary prevention implantable cardioverter-defibrillators in post-myocardial infarction patients with reduced ejection fraction over recent decades, highlighting changing clinical
EUROASPIRE VI exposes wide gaps between ESC prevention and cardiac rehabilitation recommendations and everyday care across Europe — especially in high-risk regions. This article distills core guideline recommendations, what’s new, and
Evolocumab significantly reduces first and subsequent major adverse cardiovascular events in high-risk patients without prior myocardial infarction or stroke, affirming the benefit of intensive LDL-C lowering for cumulative cardiovascular r
Lower ventricular chamber stiffness predicts adverse outcomes in Fontan patients, revealing a high-compliance, eccentric remodeling phenotype distinct from traditional stiffening hypotheses.
Long-term intensive BP control led by trained nonphysician community providers significantly lowers cardiovascular risk over 7 years, with benefits persisting 3 years post-intervention in rural China.
An international multicenter study shows ICDs effectively prevent sudden death in high-risk hypertrophic cardiomyopathy patients, demonstrating low mortality rates and significant lifesaving interventions over long-term follow-up.
Baseline plasma levels of CPVL and PIGR correlate with anthracycline-induced systolic dysfunction, offering potential early biomarkers for cardiotoxicity in hematologic malignancy patients undergoing chemotherapy.
This study reveals distinct sex differences in skeletal muscle inflammation and dysfunction in patients with HFrEF, highlighting divergent immune cell profiles linked to muscle mass and strength variations in men versus women, advancing und
This review synthesizes current evidence on myocardial fibrosis and ventricular remodeling after AVR in chronic AR, highlighting imaging biomarkers, remodeling patterns, and functional outcomes relevant to clinical practice.
This review synthesizes evidence on the prevalence and prognostic value of right ventricular dysfunction in ATTR-CM and the therapeutic impact of vutrisiran on RV function from the HELIOS-B trial, underscoring RV free wall strain as a key b
This article explores the vital role of the vagus nerve in modulating myocardial infarction outcomes through autonomic regulation, reflex pathways, and cardioprotective mechanisms, highlighting translational potential from experimental mode
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