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Quit Smoking Anytime: How Stopping in Midlife Can Preserve Your Memory and Thinking Skills
New research reveals that quitting smoking in mid to late life significantly slows cognitive decline, offering an added three years of brain health regardless of quitting age.
Early Life Sugar Restriction and Its Lasting Impact on Adult Cardiovascular Health: Insights from a Natural Experiment
Exposure to sugar rationing during the first 1000 days after conception correlates with significantly reduced cardiovascular disease risk and improved cardiac function decades later, highlighting early nutritional influences on long-term he
Long-Term Effectiveness of HPV Screen-and-Treat Strategy Versus Cytology in Cervical Cancer Screening: Insights from El Salvador’s CAPE Program
A 5-year follow-up study in El Salvador demonstrates that primary HPV screen-and-treat significantly reduces CIN2+ detection and HPV positivity compared to cytology, supporting extended screening intervals in low-resource settings.
Understanding Sex- and Age-Specific Suicide Risk Indicators: Insights from a Large Swedish Case-Control Study
This Swedish population-based study highlights how suicide risk indicators vary by sex and age, showing males and older adults exhibit fewer, but often higher absolute risk indicators, underscoring the need for tailored suicide prevention s
Review for Cervical Cancer Screening
A comprehensive 2025 systematic review informing the Canadian Task Force finds cytology remains effective into the 60s, HPV-based strategies detect more precursors but increase colposcopy and false positives, and self-sampling improves upta
Breakthrough in Enteric Fever Prevention: Efficacy and Safety of the Novel Salmonella Paratyphi A Vaccine CVD 1902
A novel live attenuated oral vaccine, CVD 1902, shows 73% efficacy against Salmonella Paratyphi A infection in a controlled human challenge model, offering promising protection with a favorable safety profile.
Early Diagnosis of Postpartum Haemorrhage: Insights from the E-MOTIVE Trial Across Africa
A nested observational study within the E-MOTIVE trial revealed that adopting a lower blood loss threshold combined with clinical signs leads to earlier diagnosis of postpartum haemorrhage, facilitating prompt interventions and reducing adv
Effectiveness and Safety of RSV Vaccination in US Adults Aged 60 Years or Older: A Comprehensive Evidence Synthesis
RSV vaccines demonstrate substantial effectiveness and acceptable safety profiles in adults aged ≥60, with diminished effectiveness in immunocompromised subgroups and a low, statistically significant increased risk of Guillain-Barré syndrom
Updated Evidence for Covid-19, RSV, and Influenza Vaccines in the 2025-2026 Season: A Comprehensive Review
A systematic review supports the continued safety and effectiveness of Covid-19, RSV, and influenza vaccines for the upcoming 2025-2026 season, highlighting detailed vaccine efficacy, safety profiles, and recommendations for at-risk populat
Telehealth Prescribing of ADHD Stimulants: Assessing Risks for Subsequent Substance Use Disorders
This study evaluates whether initiating ADHD stimulant prescriptions via telehealth affects later risks of stimulant or other substance use disorders, finding no SUD risk increase but a potential rise in stimulant use disorder risk.
Neighborhood Social Vulnerability and Racial Disparities in Schizophrenia Spectrum Disorder Prevalence: Insights from a National US Study
This national study reveals significant ethnoracial disparities in schizophrenia spectrum disorders prevalence linked to neighborhood social vulnerability, highlighting structural racism’s role in mental health inequities among non-Hispanic
Unraveling Depressive Symptom Trajectories in Early Adolescents: Insights from a 12-Month Cohort in Nanchong, China
This longitudinal study reveals distinct trajectories of depressive symptoms among Chinese adolescents, highlighting key sociodemographic and behavioral predictors that can inform early intervention strategies.
Cardiovascular Risks in Acute Dengue Infection: Insights from a Large Population-Based Cohort Study
A comprehensive Singaporean cohort study reveals increased odds of cardiovascular complications during the first 30 days post-acute dengue infection, especially in older adults, emphasizing the need for targeted cardiac monitoring.
Impact of Obesogenic Environmental Factors on Long-Term Cardiovascular Disease Risk: Insights from the Dutch OBCT Index Study
A 14-year population-based cohort study in the Netherlands found that higher Dutch OBCT index scores—reflecting obesogenic environmental characteristics—are associated with a modest but significant increase in cardiovascular disease inciden
Impact of Repealing Nonmedical Vaccine Exemptions on Kindergarten Immunization Rates in the US
State-level repeal of nonmedical vaccine exemptions significantly improves kindergarten vaccination rates across multiple vaccines, with minimal increase in medical exemptions, highlighting its role in sustaining herd immunity amid growing
Disentangling Clinical and Preclinical Obesity: Their Distinct Impacts on All-Cause Mortality Risk in the UK Biobank Study
New evidence from the UK Biobank reveals that clinical obesity, defined by obesity-related dysfunctions, significantly elevates all-cause mortality risk. Early detection and intervention are key to reducing mortality associated with both pr
Sustained Impact of Lifestyle and Metformin Interventions on Type 2 Diabetes Prevention: Insights from 21 Years of the US DPP Trial
Over 21 years, intensive lifestyle changes and metformin significantly reduced type 2 diabetes incidence in at-risk adults, with variable effects based on individual baseline risk factors, highlighting opportunities for precision prevention
Mapping the Future of US Pediatric Acute Care: Development of a National Atlas Based on Medicaid Data
A novel pediatric-specific atlas of US acute care regions was developed using Medicaid data, revealing distinct patterns in emergency and referral care and providing a foundation for targeted pediatric healthcare planning and quality improv
Optimizing Gonorrhea and Chlamydia Screening for Adolescents in Emergency Departments: Evidence from Targeted and Universal Strategies
Comparative effectiveness evidence from multicenter pediatric emergency departments demonstrates that targeted and universally offered gonorrhea and chlamydia screening increase detection rates versus usual care, highlighting the need for i
Gamified mHealth Strategies Boost Treatment Adherence and Outcomes in Late-Life Depression
Implementing gamification in mobile health psychotherapy markedly improves adherence and reduces depressive symptoms among older adults, offering a promising avenue to address mental health care needs in aging populations.
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