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Preoperative CT Was Missing in 15% of Balloon Sinus Dilations — Medicare Claims Reveal a Clinically Significant Practice Gap
A Medicare claims study of 19,692 balloon sinus dilations found 15% lacked a CT within one year; 31.8% of otolaryngologists were outliers, with a small group accounting for most missed imaging, highlighting gaps in adherence to preoperative
Most Host Countries Don’t Get Timely Access to Medicines They Help Test: An Analysis of FDA-Supported Trials (2015–2018)
A cross-sectional analysis (FDA approvals 2015–2018) found that most countries hosting pivotal trials lack timely market authorization for tested medicines, especially lower- and middle-income countries—raising ethical, regulatory, and poli
Short Program, Long Gains: A 24‑Week Multicomponent Frailty Intervention Extended Disability‑Free Survival and Delivered Net Health-System Savings Over 66 Months
A 24‑week, community-based multicomponent frailty intervention in rural Korea was associated with 6.5 additional months free from death or long‑term care eligibility and ~$7,700 per-person NHIS savings over 66 months, suggesting durable cli
Boosting Mammogram Screening Rates: What Really Works for Overdue Women?
A Singapore trial shows simple mailed reminders effectively increase overdue mammogram screenings; additional incentives or digital interventions offer no significant benefit.
Reduced Arsenic in Drinking Water Tied to Large Drops in Cancer and Cardiovascular Mortality
A prospective cohort in Bangladesh found that declines in urinary arsenic were associated with substantially lower chronic-disease mortality—including cancer and cardiovascular deaths—supporting public-health efforts to reduce arsenic expos
The Power of Persistence: How Consistent Moderate Exercise Significantly Lowers Digestive Cancer Risk
A Harvard study following 230,000 people over 32 years shows that regular, moderate exercise sustained over time is more effective at preventing digestive system cancers than sporadic high-intensity workouts.
A Novel H3N2 Variant on the Rise: What Clinicians and Public Health Systems Need to Know for 2025–26
Emerging H3N2 subclade K has driven increased influenza activity abroad and may seed the 2025–26 northern hemisphere season. Surveillance gaps complicate risk assessment; vaccination and early antiviral use remain central clinical strategie
Bird Flu Returns: Understanding the Risks and Staying Safe
An adult male in Washington has tested positive for avian flu, marking a resurgence after 9 months. This article explores the scientific evidence, recent outbreaks, and practical advice to prevent infection.
Stopping Smoking Is Associated With Better Recovery From Other Substance Use Disorders: Longitudinal Evidence From a US National Cohort
A longitudinal, nationally representative cohort study found that within-person transition from current to former cigarette smoking was associated with a 30–43% higher odds of sustained recovery from other substance use disorders, supportin
Unlocking Longevity: The Science of Sleep and Its Vital Role in Health
Quality sleep, balancing deep NREM and REM phases, is crucial for immunity, brain function, and disease prevention, highlighting sleep’s key role in longevity and overall health.
GanLum (KLU156): A New Class of Antimalarial Showing 97.4% PCR‑Corrected Cure in Phase III
A Phase III trial of ganaplacide‑lumefantrine (GanLum, KLU156) met its primary non‑inferiority endpoint vs artemether‑lumefantrine, with a PCR‑corrected Day‑29 cure rate of 97.4% (estimand). The drug combines a novel mechanism (ganaplacide)
Distinct and Shared Risk Profiles for Suicide Attempt Versus Suicide: Insights from Danish Registers and Genomic Data
A large Danish register and genetic study shows overlapping but distinct environmental and genetic risk factors for nonfatal suicide attempts and death by suicide, with chronic and functional health problems linked more to attempts and seve
Sexual Assault and the Long Shadow of the Body: Higher 5‑Year Risk of Functional Somatic Disorders and Chronic Widespread Pain
A prospective Danish cohort found that adults reporting lifetime sexual assault had substantially higher 5‑year incidence of functional somatic disorders—especially multiorgan FSD and chronic widespread pain—after adjustment for psychosocia
Higher Ultraprocessed Food Intake Linked to Increased Risk of Early‑Onset Colorectal Adenomas in Women
In a prospective analysis of 29,105 women from the Nurses’ Health Study II, greater consumption of ultraprocessed foods was associated with a 45% higher odds of early‑onset conventional colorectal adenomas, independent of obesity and other
Consistency Over Excess: Long-term Adherence to Physical Activity Guidelines Reduces Digestive System Cancer Risk
A pooled analysis of three US cohorts shows that maintaining guideline-level activity (~17 MET‑hours/week) consistently over decades is associated with substantial reductions in digestive system cancer incidence and mortality—comparable to
High‑Dose Influenza Vaccine Reduces Hospitalisations in Older Adults
A prespecified pooled analysis of two large randomised pragmatic trials (DANFLU-2 and GALFLU) found high‑dose influenza vaccine reduced hospitalisation for influenza or pneumonia by 8.8% versus standard‑dose in adults ≥65 years, with larger
Nirsevimab in Chile’s First National RSV Campaign: 76% Reduction in RSV Hospitalisations and 85% Fewer ICU Admissions in Infants
A nationwide retrospective study from Chile finds that a universal nirsevimab immunisation strategy in 2024 reduced RSV-related lower respiratory tract infection hospitalisations by 76% and ICU admissions by 85%, with an NNT of 35 to preven
Screening Children and Young Adults for Familial Hypercholesterolemia: Clinically Helpful but Not Cost‑Effective
A modeling study found that sequential population screening for familial hypercholesterolemia (FH) at ages 10 or 18 is clinically effective but not cost‑effective versus usual care, unless follow-up monitoring and lifestyle interventions fo
Home‑Delivered DASH Groceries Lower Blood Pressure and LDL in Black Urban Residents — but Benefits Fade After Support Ends
The GoFresh randomized trial found that 12 weeks of home‑delivered DASH‑patterned groceries plus dietitian counseling reduced systolic BP by 3.4 mm Hg versus cash stipends and lowered LDL; effects were not sustained three months after the i
rVSVΔG‑LASV‑GPC Lassa Vaccine Shows Broad Immunogenicity and Acceptable Safety in Phase 1 Trial
A phase 1 trial of the rVSV‑vectored Lassa vaccine demonstrated dose-dependent transient reactogenicity, no vaccine‑related serious adverse events or hearing loss, and robust, durable humoral and cellular responses across doses and lineages
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