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A comprehensive simulation study evaluates the cost-effectiveness of semaglutide for secondary cardiovascular prevention in US adults without diabetes, finding significant health benefits but highlighting the need for price reductions to en
A large-scale analysis of 239,890 patients in England reveals that Black, Asian, and mixed-ethnicity patients hospitalized for heart failure have significantly lower mortality rates than White patients, largely due to better pharmacological
This evidence-based review analyzes the adoption and clinical outcomes of telemedicine for post-ED follow-up, highlighting that while utilization is currently low (2.8%), it offers a safe alternative to in-person care without increasing ret
The 2024 National Firearms Survey reveals that 29.8 million US adults acquired firearms between 2021 and 2024. This trend introduced 11.2 million new owners, significantly increasing household exposure for millions of adults and children, r
This review analyzes ophthalmic drug shortages from 2001 to 2024, revealing that eye medications face longer shortage durations than other drug classes, significantly influenced by patent status and manufacturing transparency.
This article outlines new expert consensus on conducting rigorous qualitative research in internal medicine, providing a roadmap for investigators to move beyond numbers and capture the human experience of healthcare through methods like in
A large-scale analysis of the VA Million Veteran Program reveals that TBI, depression, and specific military environmental exposures significantly elevate the 10-year risk of Alzheimer’s and related dementias, highlighting critical targets
A massive study of nearly 290,000 participants reveals that severe obesity (BMI ≥40) triples the risk of heart failure and nearly triples the risk of atrial fibrillation, with significant sex-based differences in stroke and mortality risk.
The MUTTON-HF trial evaluates whether culturally and medically tailored meals, incorporating traditional Diné (Navajo) foods, can improve clinical outcomes and quality of life for Indigenous heart failure patients facing nutrition insecurit
A comprehensive meta-analysis of 121.8 million individuals confirms that RSV vaccines are approximately 75% effective against hospitalization and severe disease in older adults, despite low global uptake and a rare risk of Guillain-Barré sy
A prospective study of over 112,000 adults in Mexico City reveals that standard CVD risk scores consistently overestimate 10-year fatal risk. Recalibration of the Globorisk-fatal model significantly improves predictive accuracy, highlightin
This 24-month Belgian cohort study demonstrates that natural MPXV infection induces more durable and robust immunity than MVA-BN vaccination. While clinical symptoms mostly resolve within a year, persistent scarring remains common, and vacc
A landmark pragmatic randomized controlled trial in Vietnam reveals that proactive Quitline referrals are as effective as nurse-led counseling and nicotine replacement therapy for smoking cessation among people living with HIV, offering a s
A groundbreaking clinical trial demonstrates that medically tailored meals featuring traditional Indigenous foods can significantly improve heart failure outcomes and food security in rural Navajo communities.
This randomized clinical trial demonstrates that combining high-intensity circuit training with targeted sleep health interventions significantly improves objective sleep quality and cardiometabolic markers in young women, outperforming eit
A randomized clinical trial demonstrates that combining high-intensity circuit training (HICT) with sleep health (SH) counseling significantly outperforms mono-interventions in improving sleep efficiency, reducing wakefulness, and enhancing
A cross-sectional analysis of 841 workers across China reveals a high prevalence of modifiable cancer risk factors, including poor diet, smoking, and low screening rates. The study highlights significant regional disparities, calling for ta
A large-scale cluster-randomized trial in Singapore demonstrates that releasing male Aedes aegypti mosquitoes infected with the wAlbB Wolbachia strain significantly suppresses wild-type populations and reduces the incidence of symptomatic d
A comprehensive meta-analysis of longitudinal studies involving over 540,000 participants reveals that spirituality and religious involvement are associated with a 13-18% reduction in harmful alcohol and drug use, offering significant impli
A large-scale Swedish study evaluates the nutritional adequacy of the EAT-Lancet diet. Findings suggest it provides sufficient micronutrients for most, though women may face an increased risk of anemia, highlighting the need for careful die
