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A study reveals significant variability in ALSFRS-R analysis methods across 45 ALS trials, impacting treatment effect estimates and increasing false-positive risks, with implications for clinical decision-making and drug development.
A 36-year prospective study demonstrates that cumulative BMI burden from childhood to adulthood significantly elevates risks of metabolic multimorbidity, with distinct life-stage patterns and sex-specific vulnerabilities.
A cohort study of over 1 million cancer patients revealed significant reductions in 1-year survival rates during 2020-2021 compared to pre-pandemic trends, with an estimated 17,390 excess cancer deaths attributable to pandemic-related care
The Systems Analysis and Improvement Approach for Mental Health (SAIA-MH) significantly improved functional outcomes, medication adherence, and appointment attendance in Mozambican outpatient clinics, offering a scalable model for low-resou
A proactive digital mental health platform improved mental health outcomes for health care workers, with notable benefits for Black and female participants in work productivity and sustained depression reduction.
A randomized trial found that a $80 monthly produce prescription did not significantly improve HbA1c levels or reduce healthcare utilization in diabetic patients at risk of food insecurity.
A novel statistical model predicts chronic immune thrombocytopenia (ITP) in children at diagnosis, using age, sex, immunoglobulin levels, and lab values, offering early clinical guidance.
In a large survey of adult ear piercings, auricular cartilage piercings had higher complication and removal rates than lobule piercings, reinforcing the need for careful counseling and informed consent.
In a large Medicare study, hospitals under Maryland’s global budget model showed modest but significant improvements in cancer surgery outcomes, driven by fewer complications and shorter stays, with lower inpatient spending.
In two large U.S. cohorts, greater adherence to healthy dietary patterns—especially DASH—was associated with less subjective cognitive decline and slightly better objective cognition.
A novel matching approach using 911 call time and patient characteristics can effectively identify duplicate EMS responses, enabling more accurate patient-level inferences from response-based datasets with 100% sensitivity and up to 98.6% s
This qualitative study explores systemic barriers faced by underrepresented scholars in biomedical research, revealing challenges in academic culture, external pressures, and strategies for resilience through interviews with 78 early-career
A cross-sectional analysis of health technology assessments across G20 nations reveals significant disparities in access to CAR T-cell therapies, with only 48% of approved indications recommended for reimbursement and a median 1.54-year del
A new study reveals that neurologists receiving $1,000 or more from drug manufacturers were over 4 times more likely to prescribe expensive brand-name MS medications when generics were available, driving up costs for patients and the health
A large UK Biobank cohort study of 121,017 postmenopausal women reveals that earlier menopause significantly increases risks of multimorbidity progression, with women experiencing premature menopause facing 32% higher risk of developing fir
A retrospective cohort study reveals that dementia patients with preferred language other than English are more likely to have documented goals-of-care discussions yet experience significantly higher hospital-based healthcare utilization ne
A large-scale study of 390,000 hospitalizations reveals that while racial concordance modestly increases advance care planning (ACP) discussions, physician race and systemic quality initiatives play significant, nuanced roles in end-of-life
A large-scale retrospective cohort study involving nearly 300,000 women demonstrates that undergoing a cesarean delivery for a first birth is associated with an 11% lower likelihood of a second live birth and a 28% higher reliance on assist
This study examines patient engagement with home blood pressure monitoring (HBPM) in a remote management program, revealing that accessibility and support do not always guarantee high patient compliance.
This systematic review analyzes the profound underrepresentation of African populations in high-impact clinical trials, revealing a stark disparity in cardiovascular and general medical research that limits the global applicability of evide
