Pediatrics
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In Utero Embolization for Fetal Vein of Galen Malformation: Early Clinical Insights and Outcomes
This article reviews early clinical results from a US single-center study on in utero embolization for fetal Vein of Galen malformation, highlighting potential survival benefits alongside risks of preterm delivery.
Early Childhood High Blood Pressure Predicts Premature Cardiovascular Mortality: Insights from a 50-Year Longitudinal US Cohort
Elevated blood pressure at age 7 significantly increases the risk of premature cardiovascular mortality by mid-adulthood, underscoring the need for early-life blood pressure monitoring and intervention.
Midazolam Outperforms Melatonin as Premedication for Anxiety in Children Undergoing Elective Surgery: Insights from the MAGIC Trial
The MAGIC trial reveals midazolam’s superior efficacy over melatonin in reducing preoperative anxiety in children undergoing general anaesthesia, despite melatonin’s favorable safety profile. Challenges in recruitment and implications for f
Unlocking Mental Health in Children with Chronic Illness: The Crucial Roles of Physical Activity and Social Play
Children with chronic physical illnesses face higher risks of mental health issues, partly due to early-life constraints on social and physical activities. Encouraging active play and social engagement may reduce these risks.
Prognostic Value of 2D Speckle Tracking Echocardiography in Multisystem Inflammatory Syndrome in Children: Insights From the MUSIC Study
This multicenter study highlights the utility of 2D speckle tracking echocardiography for early detection and prognostication of left ventricular dysfunction in MIS-C, informing cardiovascular risk and management.
Daily Emollient Use in Infants: A Promising Strategy to Prevent Pediatric Atopic Dermatitis
A large pragmatic trial demonstrates that daily emollient application starting before 9 weeks of age significantly reduces the risk of atopic dermatitis by 24 months in infants not selected for high risk, offering a feasible preventive appr
ADHD Drugmakers Double Marketing Spending to Clinicians: Implications for Prescribing and Patient Care
Pharmaceutical companies have significantly increased marketing payments to clinicians for ADHD medications, particularly targeting advanced practice clinicians. The impact of this trend on prescribing patterns and clinical benefits remains
Enhancing Early Risk Stratification of Severe Childhood Febrile Illness in Rural Asia Using sTREM1 Biomarker
A multicountry study across Asia demonstrates soluble TREM1’s superior accuracy over traditional clinical signs in predicting severe febrile illness in children, potentially transforming triage in resource-limited settings.
Promising Immunogenicity and Safety of the Live-Attenuated Intranasal RSV Vaccine in Infants and Toddlers
This phase I/II trial demonstrates that the live-attenuated intranasal RSV vaccine (RSVt) is immunogenic and well-tolerated in infants and toddlers, offering a potential new preventive option against RSV infection.
Micronutrient Supplementation Modulates Gut Microbiome in Children with ADHD: Insights from the MADDY Study
The MADDY study reveals that micronutrient supplementation in children with ADHD alters gut microbial diversity and composition, notably increasing beneficial butyrate-producing bacteria, potentially underpinning improved behavioral outcome
Varenicline Significantly Enhances Nicotine Vaping Cessation in Youth: Insights from a Landmark Randomized Clinical Trial
A randomized clinical trial demonstrates that varenicline, combined with behavioral counseling, markedly improves nicotine vaping cessation rates in youth aged 16-25 who vape daily and do not regularly smoke tobacco.
Does Increasing Cigarette Use Stabilize Mood? Insights from a 6-Year Real-Time Adolescent Study
Longitudinal observational data reveal that as adolescents increase cigarette use, their immediate post-smoking mood stabilizes, with boys showing stabilization in background mood as well.
Harnessing Mobile Health to Improve ADHD Symptoms and Executive Functions in Children: A Randomized Controlled Trial of Tailored Exercise Rehabilitation
A tailored, app-supported exercise program delivered via mobile health significantly improves core ADHD symptoms and executive functions in children, demonstrating comparable effectiveness to traditional face-to-face exercise guidance.
Impact of BMI and Physical Activity on Subsequent Neoplasm Risk in Childhood Cancer Survivors: Insights from the CCSS Cohort
Obesity increases, while higher physical activity decreases, risk of subsequent neoplasms among childhood cancer survivors, highlighting lifestyle intervention potential for cancer prevention.
Maternal Bivalent Prefusion F RSV Vaccine Significantly Reduces Infant Hospitalisation in UK: Real-World Evidence from a Multicentre Study
A UK-wide multicentre study shows maternal bivalent RSV prefusion F vaccination reduces infant hospitalisation for RSV-associated ALRI by up to 72%, confirming real-world effectiveness matching clinical trials.
Adjunct-to-Insulin Therapy Using SGLT2 Inhibitors in Youth with Type 1 Diabetes: Clinical Impact and Renal Outcomes
SGLT2 inhibitors adjunct to insulin improve glycemic control, reduce hyperfiltration, and are generally safe in youth with type 1 diabetes under careful ketone monitoring and DKA risk mitigation.
Diverging Pediatric Recommendations on COVID-19 Vaccination: The AAP Advocates Routine Immunization for Young Children Amid Federal Policy Shift
The American Academy of Pediatrics recommends COVID-19 vaccination for all young children aged 6-23 months, diverging from current CDC policies that advise shared decision-making for healthy children. This review analyzes epidemiologic data
Prenatal Exposure to Chlorpyrifos and Its Long-Term Impact on Brain Development and Motor Function in Children: Evidence from Imaging and Cohort Studies
Elevated prenatal chlorpyrifos exposure is linked to widespread brain structural abnormalities, reduced neuronal density, and impaired motor functions in children, underscoring the need for exposure minimization during pregnancy.
Exploring Fecal Microbiota Transplantation for Autism Spectrum Disorder: Efficacy, Safety, and Future Directions
Fecal microbiota transplantation (FMT) shows promise in improving gastrointestinal and behavioral symptoms in children with autism spectrum disorder (ASD), but further rigorous trials are needed to confirm its efficacy and optimize protocol
Childhood Verbal and Physical Abuse Harm Adult Mental Health
Research shows childhood abuse significantly increases the risk of poor adult mental health, with lasting impacts from physical and verbal abuse.
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