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The FDA has rejected Sydnexis’s low-dose atropine eye drop SYD-101 for controlling childhood myopia progression despite promising trial results, highlighting challenges in demonstrating long-term efficacy and clinical significance in
A single‑arm trial of AAV‑OTOF (Anc80L65) in 10 patients (1.5–23.9 years) with autosomal recessive deafness 9 showed good tolerability and rapid, clinically meaningful hearing gains, with optimal outcomes in children aged 5–8 years; longer
A 2022–2024 nonblinded cohort study found OTOF gene therapy produced rapid, durable gains in auditory thresholds, speech perception, mismatch-negativity responses, and music perception versus cochlear implantation in children with genetical
National APSU surveillance (1999–2024) found 479 definite congenital CMV cases and dramatic under-ascertainment versus expected prevalence; symptomatic infants increasingly receive antivirals. Expanded surveillance, newborn screening, and c
A prospective cross-sectional study finds unilateral chronic otitis media with effusion (COME) in children is associated with poorer spatial release from masking and high tinnitus prevalence, suggesting potential central auditory consequenc
AI-RAPNO synthesizes current AI developments for pediatric brain tumour imaging and provides practical recommendations to improve trustworthiness, generalisability, and clinical implementation of AI-driven response assessment using the RAPN
In 185 children receiving unilateral cochlear implants, residual acoustic hearing favored the non-implanted ear in quiet (especially for SSD), but noise attenuated that advantage. Shorter auditory deprivation and longer CI experience reduce
Early cochlear implantation in children with prelingual single-sided deafness improves spatial hearing and cognitive outcomes, supporting neurodevelopment and mitigating risks of auditory deprivation and cortical reorganization.
A retrospective 10‑year series from Perth Children’s Hospital reports heterogeneous long‑term outcomes after pediatric cochlear implantation for single‑sided deafness; earlier implantation (within 1 year) was associated with greater l
In a cohort of 50 individuals with CHARGE syndrome, GI problems affected 64% and constipation 48%, with constipation associated with lower PedsQL GI scores and greater comorbidity; younger patients had more diverse GI issues while older pat
DB-OTO, a hair-cell-specific dual-AAV gene therapy encoding full-length human otoferlin, achieved dose-dependent and sustained auditory restoration in OTOF-deficient mice, supporting an ongoing Phase I/II pediatric trial.
A 5.5-year prospective cohort found lower-extremity apophysitis common in schoolchildren (1265 episodes in 1670 children), median symptom duration 3–4 weeks, and higher risk with soccer, handball, basketball and jump gymnastics but not from
The FAIR systematic review and consensus synthesizes evidence on prevention strategies and modifiable risk factors for upper‑extremity injury in female/woman/girl athletes, highlighting shoulder exercise programmes and key research gaps.
A case-crossover study of 51 boys (8–12 y) shows higher ear and skin temperatures during hot summer football training (≥25 °C), with no change in hydration by urine density and no severe heat illness noted. Findings highlight risk threshold
Favism, a hereditary enzyme deficiency causing red blood cell breakdown upon exposure to certain triggers like fava beans, is preventable with proper diagnosis and management. This article explores its clinical features, diagnosis, treatmen
This study identifies clinical and demographic factors associated with positive blood cultures in hospitalized children across nine African and Asian countries, aiming to improve diagnostic stewardship amidst resource constraints.
This article reviews two types of flu vaccines for children—live attenuated and inactivated—over 20 years, demonstrating both provide meaningful protection and highlighting improvements that have enhanced their effectiveness.
This study elucidates how copy number variants (CNVs) contribute to variability in child psychopathology and cognitive function, highlighting specific CNV regions and aggregated genetic risk affecting attention and cognitive domains during
This study identifies reduced neural efficiency during threat processing as a biomarker in pediatric anxiety disorders, linked to diagnosis and poorer CBT outcomes, offering potential for patient stratification and novel intervention target
A large retrospective cohort study found no significant association between perinatal or early infant antibiotic exposure and subsequent hospitalization for infections in early childhood, providing reassurance about the cautious use of anti
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