Section
Brazilian scientists have developed Polylaminin, a protein derived from human placenta that stimulates nerve regeneration. In early trials, six paralyzed patients regained the ability to walk, prompting official Phase I clinical trials to b
The SUPER-FIN randomized trial reveals that cast immobilization is a viable, non-inferior alternative to surgery for unstable Weber B ankle fractures with a congruent mortise, leading to fewer complications and avoiding unnecessary hardware
The RESOLVE trial demonstrates that graded sensorimotor retraining provides modest pain relief for chronic low back pain. A secondary analysis reveals that these benefits are consistent across most patient subgroups, suggesting that the int
The ROXI-VTE trials demonstrate that inhibiting the Factor XI catalytic domain significantly reduces postoperative VTE compared to enoxaparin. While blocking Factor XIIa-mediated activation showed promise, it failed to meet superiority, hig
The RESTORE trial’s 3-year follow-up reveals that Cognitive Functional Therapy (CFT) provides sustained reductions in disability and pain for chronic low back pain compared to usual care, offering a transformative, evidence-based appr
The CLEAT trial demonstrates that an 8-week cycling and education program (CHAIN) significantly improves function in hip osteoarthritis compared to usual physiotherapy. Despite falling just short of the clinical importance threshold, its hi
A groundbreaking clinical trial explores whether injecting steroids into the knee’s infrapatellar fat pad can alleviate pain and protect cartilage. While primary pain targets weren’t met, the secondary findings offer a fascinating gli
The PACBACK randomized trial reveals that clinician-supported biopsychosocial self-management significantly reduces one-year disability in patients with acute low back pain at high risk of chronicity, whereas spinal manipulation alone offer
The 10-year FIMPACT trial results confirm that arthroscopic subacromial decompression (ASD) provides no superior relief for subacromial pain syndrome compared to placebo surgery or exercise therapy, fundamentally challenging traditional sur
Low-certainty evidence suggests cryotherapy may slightly reduce blood loss, pain, and swelling after total knee replacement, but clinical relevance remains uncertain.
The 10-year TOPKAT randomized trial found no clinically important difference in Oxford Knee Score between partial (PKR) and total knee replacement (TKR) for medial compartment osteoarthritis, similar revision/reoperation rates, and cost-eff
In a large single‑institution cohort of oropharyngeal squamous cell carcinoma, proton therapy was associated with a higher 3‑year rate of osteoradionecrosis than IMRT (6.4% vs 2.7%), though severe ORN remained uncommon.
The APPROACH randomized trial found once-weekly navepegritide significantly increased annualized growth velocity and produced favorable skeletal alignment and physical-function improvements in children with achondroplasia, with an acceptabl
A 12-year-old female with primary failure of eruption (PFE) affecting the right mandibular first molar is treated successfully via extraction and orthodontic repositioning, restoring function and occlusion.
A pooled prospective analysis of 18,935 hips found severe pincer morphology (LCEA ≥45°) was associated with a 1.5-fold higher odds of incident radiographic hip osteoarthritis within 8 years; moderate pincer (LCEA ≥40°) showed no overall ass
A prospective cohort using Apple Watch data demonstrated meaningful increases in step count, standing time and gait speed after unilateral total knee arthroplasty, peaking at 6 months and persisting at 12 months.
Systematic review of 71 RCTs reveals that intra-articular hyaluronic acid injections offer initial symptom worsening but significant long-term relief, especially in early-stage knee osteoarthritis and older women; molecular weight’s role re
A practical, clinician-focused summary of the 2025 German S2k consensus on preparticipation evaluations (PPE) for healthy adults—prioritizing history and physical exam, targeted testing, individualized exercise prescriptions, and research n
Systematic review and meta-analysis of 22 studies finds player contact and non-contact mechanisms dominate; ankle (25.8%) and knee (15.5%) injuries account for 41% of injuries. Females have higher rates of knee, concussion, and ball-contact
A 2025 meta-analysis of 13 trials found neuromuscular training produced large improvements in athletes’ balance (overall SMD 1.47), with benefits for both static and dynamic domains. Results support incorporating targeted neuromuscula
