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Recently hospitalized adults with high ACEs describe how routine inpatient care can reactivate medical trauma. Residents and care teams identify barriers to trauma-informed communication.
A historical analysis reveals that policy decisions, financial incentives, and for-profit dialysis centers have contributed to persistent underuse of home dialysis in the US, especially among marginalized populations.
This review synthesizes key findings evaluating olorofim’s clinical effectiveness and safety in patients with refractory disseminated coccidioidomycosis, emphasizing its potential role amid limited treatment options.
This study develops and compares predictive models incorporating claims and patient-reported data to forecast time to first opioid use disorder (OUD) or overdose (OD) among older adults with chronic pain on opioids, identifying key risk fac
Patients whose physicians demonstrate higher clinical knowledge are less likely to receive low-value healthcare services, reducing unnecessary medical spending and optimizing care quality in elderly Medicare beneficiaries.
The American College of Physicians urges Congress and regulators to modernize DSHEA, require premarket FDA review, strengthen surveillance, standardize labeling, and improve clinician tools to protect the public from unsafe or misleading di
Older adults with MASLD, especially those aged 75 and above, experience a high burden of polypharmacy linked to multimorbidity, necessitating careful medication management to balance disease control and geriatric vulnerabilities.
The G-MASLD study evaluated the diagnostic accuracy of non-invasive fibrosis tests across 41 countries, revealing regional variability and identifying Agile-3+ and Agile-4 as the most accurate for advanced fibrosis and cirrhosis in MASLD pa
Mosaic loss of Y chromosome (mLOY) in men is strongly associated with diminished lung function, increased emphysema severity, and faster epigenetic aging, positioning mLOY as a novel biomarker for respiratory aging and COPD risk in males.
Emerging obesity pharmacotherapies targeting entero-pancreatic hormones deliver substantial weight loss and improve multiple obesity-related complications, heralding a treat-to-target paradigm in obesity management with personalized, compli
A genome-wide meta-analysis of 2.8 million individuals reveals genetic links between irritable bowel syndrome, brain-gut pathways, and cardiometabolic traits, highlighting novel therapeutic targets involving triglyceride metabolism.
A pragmatic RCT in an Australian ICU found the ABCDEF bundle did not reduce delirium incidence or duration but improved patients’ ability to perform usual activities at 90 days post-discharge, suggesting possible long-term quality of
A VA pilot study shows that pharmacist-led provision and 12-month dispensing of hormonal contraception is feasible, improves access, and enhances satisfaction among women Veterans and pharmacists.
This study examines how temporal cortisol secretion changes in benign adrenal incidentalomas relate to long-term cardiometabolic outcomes and mortality, highlighting the significance of persistent mild autonomous cortisol secretion for hype
Prolonged mild sleep restriction of 1.5 hours per night over six weeks leads to modest weight gain, increased adiposity, and elevated leptin levels, highlighting the importance of adequate sleep in weight management and cardiometabolic risk
This study highlights how enhanced social support within primary care teams correlates with lower turnover intentions, emphasizing the potential of network-based interventions to improve workforce stability and well-being in healthcare sett
A NIDDK workshop highlighted the crucial role of real-world evidence in addressing gaps about GLP-1 receptor agonists’ safety, effectiveness, adherence, and economic impact to improve clinical and regulatory decision-making.
This article reviews the incidence and predictors of recurrent VTE following anticoagulation for isolated distal deep vein thrombosis, highlighting key risk factors and implications for treatment duration and patient management.
A randomized trial showed no significant differences in 6- and 12-month cognitive, physical, and quality of life outcomes between early restrictive and liberal fluid resuscitation in sepsis-induced hypotension.
The Predictive Aplastic Score System (PASS) accurately distinguishes acquired aplastic anemia from inherited bone marrow failure syndromes using seven clinical variables, enabling rapid diagnosis and improved treatment decisions in adults.
