Internal Medicine
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NSAID Co-prescription in Atrial Fibrillation: Doubling the Bleeding Burden Across All Oral Anticoagulants
A nationwide cohort study demonstrates that NSAID use in patients with atrial fibrillation on oral anticoagulants nearly doubles the risk of hospital-diagnosed bleeding, with significant risks observed across all anticoagulant types and mul
Oral Magnesium Reduces Risk of Death and Hospitalization in Heart Failure Patients with Hypomagnesemia
A large-scale study of US veterans demonstrates that oral magnesium therapy significantly improves outcomes in heart failure patients with hypomagnesemia, especially those with levels below 1.3 mg/dL. Conversely, supplementation in normomag
Guided Antiplatelet De-escalation Proves Safe in High Atherothrombotic Risk ACS Patients: Insights from TROPICAL-ACS
Post-hoc analysis of the TROPICAL-ACS trial demonstrates that platelet function testing-guided de-escalation of dual antiplatelet therapy from prasugrel to clopidogrel is safe and effective in ACS patients, regardless of their atherothrombo
Colchicine for Long COVID: Randomized Trial Finds No Benefit in Functional Recovery or Inflammatory Resolution
A multi-center randomized clinical trial published in JAMA Internal Medicine demonstrates that colchicine, despite its potent anti-inflammatory properties, fails to improve 6-minute walk test distances or inflammatory markers in patients su
Synergistic Supplementation: How L-Carnitine and Selenium Enhance Methimazole Efficacy in Graves’ Disease
A randomized trial reveals that adding L-carnitine and selenium to methimazole therapy significantly accelerates TRAb negativity, increases remission rates, and reduces cumulative drug exposure in patients with Graves’ disease.
Selenium Supplementation Fails to Improve Remission or Quality of Life in Graves’ Hyperthyroidism: Findings from the GRASS RCT
The GRASS trial, a double-blind multi-centre RCT, found that adding 200 µg of selenium daily to standard antithyroid drug therapy does not increase remission rates or improve quality of life in patients with newly diagnosed Graves’ hyperthy
Oral Corticosteroids During Pregnancy: A Nationwide Study Reassures on Gestational Diabetes Risk
A large-scale Korean cohort study involving 1.3 million pregnancies found no overall association between oral corticosteroid use and gestational diabetes risk, supporting their clinical use when indicated, despite a minor risk increase obse
Hypermagnesemia as a Potent Predictor of Adverse Outcomes in Heart Failure: New Evidence from the GALACTIC-HF Trial
A secondary analysis of the GALACTIC-HF trial demonstrates that hypermagnesemia, rather than hypomagnesemia, is significantly associated with increased cardiovascular death and worsening heart failure in patients with HFrEF, challenging cur
The Limits of Collaborative Care: Why the CLARO Trial Found No Added Benefit for OUD and Comorbid Mental Illness
The CLARO randomized clinical trial investigated whether a collaborative care model could improve outcomes for patients with opioid use disorder and co-occurring depression or PTSD. The study found no statistically significant advantages ov
Beyond the Golden Years: Young COPD and Early Lung Function Decline as Critical Drivers of Premature Mortality and Cardiovascular Risk
Recent evidence reveals that COPD in adults under 50 is more prevalent than previously thought, significantly increasing the risk of premature death and heart failure. Furthermore, impaired lung function trajectories starting in childhood p
Idursulfase Extends Survival by a Decade in Mucopolysaccharidosis II: Final Results from the 18-Year Hunter Outcome Survey
The final report of the Hunter Outcome Survey (HOS) confirms that idursulfase treatment for Mucopolysaccharidosis II provides a 10-year survival benefit and a 57.9% reduction in mortality risk compared to untreated cohorts, alongside sustai
Beyond the Alarm: Does CGM Truly Restore Hypoglycemia Awareness in Older Adults with Type 1 Diabetes?
This post hoc analysis of the WISDM study evaluates whether 52 weeks of continuous glucose monitoring (CGM) improves impaired awareness of hypoglycemia (IAH) in older adults. While severe events decreased, physiological awareness remained l
Beyond Glucose: SGLT-2 Inhibitors and GLP-1 Receptor Agonists Slow Frailty Progression in Older Adults
A large-scale Medicare study suggests that SGLT-2 inhibitors and GLP-1 receptor agonists significantly slow frailty progression in older adults with type 2 diabetes, independent of their cardiovascular benefits, marking a potential shift in
Tirzepatide Shows Unprecedented Weight Loss and Reduced Insulin Demand in Adults with Type 1 Diabetes and Obesity
A Phase 2 trial demonstrates that tirzepatide significantly reduces body weight, HbA1c, and total daily insulin requirements in adults with type 1 diabetes and obesity, offering a promising therapeutic strategy for managing metabolic health
Lay Health Worker-Led Symptom Monitoring Slashes Acute Care Use and Costs in Older Cancer Patients
A multisite RCT published in JAMA reveals that lay health worker-led symptom assessments for older adults with cancer significantly reduce emergency department visits, hospitalizations, and healthcare costs, offering a scalable model for ge
Low-Dose Amitriptyline vs. CBT-I for Comorbid Insomnia: Statistical Non-Inferiority Meets Clinical Reality
A multicenter trial finds low-dose amitriptyline non-inferior to CBT-I for comorbid insomnia based on a liberal margin. However, CBT-I yielded superior clinical response rates and fewer side effects, reinforcing its status as the gold-stand
One in Three Older Emergency Admissions Face Cognitive Morbidity: Insights from the ORCHARD-EPR Study
A large-scale cross-sectional study of 51,202 admissions reveals that 35.6% of patients aged 70 and older experience cognitive morbidity, predominantly delirium. The findings underscore the urgent necessity for hospital-wide screening and m
Subcutaneous Lidocaine-HP-β-CD: A Potential Disease-Modifying Breakthrough for Post-COVID Condition
A 36-week observational study demonstrates that subcutaneous lidocaine-HP-β-CD significantly improves physical and mental quality of life and reduces symptom burden in patients with post-COVID condition, offering a scalable, home-based ther
Beyond Congestion: The Wet-Cold Phenotype Drives Mortality in Obese HFpEF
A hemodynamic study of 227 HFpEF patients reveals that 34% exhibit a low-output phenotype. This cold status, especially when combined with congestion, significantly increases mortality risk in overweight and obese individuals, highlighting
Melatonin Does Not Prevent Delirium in the Intensive Care Unit: Insights from a Comprehensive Meta-Analysis
A recent systematic review and meta-analysis of 13 randomized controlled trials concludes that melatonin fails to reduce the incidence of delirium or mortality in critically ill patients, challenging the routine use of this supplement in th
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