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A single‑centre randomized trial in China found that 7 days of remote ischemic conditioning (RIC) reduced average systolic BP by about 4.8 mm Hg versus sham in patients with essential hypertension (SBP ≥140 mm Hg), with good tolerability.
The GoFresh randomized trial found that 12 weeks of home‑delivered DASH‑patterned groceries plus dietitian counseling reduced systolic BP by 3.4 mm Hg versus cash stipends and lowered LDL; effects were not sustained three months after the i
The PERMET randomized, double-blind trial found that 6 months of metformin did not improve 6-minute walk distance or other functional endpoints in people with lower extremity peripheral artery disease (PAD) without diabetes.
In a prospective Beijing cohort (BLINDSCE), each additional hour of daily sedentary time was associated with a 1.18-point lower baseline intrinsic capacity and a 0.48-point greater decline over 1 year, suggesting sedentary behavior is a mod
A meta-analysis of 36 RCTs (n=2,500) found aerobic exercise significantly reduces depressive symptoms in people with chronic illness (Hedges’ g -0.73). A weekly dose of ≈405 MET‑min (≈120–135 min of moderate aerobic activity) reaches
A pooled analysis of three population cohorts shows lean MASLD carries higher risks of liver-related events and all-cause and liver-related mortality despite lower cardiovascular event risk compared with non-lean MASLD.
Nonceliac gluten/wheat sensitivity affects about 1 in 10 people worldwide, with strong links to female sex, psychological distress, and irritable bowel syndrome. This article explores its prevalence, symptoms, challenges in diagnosis, and i
In a 48‑week multicenter phase 2 trial, weekly amylin receptor agonist eloralintide produced dose‑dependent mean weight loss of 9.4%–20.9% versus 0.4% for placebo, with improved waist circumference and cardiometabolic markers; tolerability
Serial indirect calorimetry–measured hypermetabolism is independently associated with more rapid CT-quantified muscle wasting and higher risk of energy deficit in critically ill adults, suggesting personalized metabolic monitoring could gui
Elevated vitamin B12 levels from mid- to late life correlate with reduced rates of cognitive decline across language, memory, and executive function domains, independent of folate status, highlighting potential preventative strategies again
Eli Lilly and NVIDIA have partnered to launch the largest AI-powered supercomputing platform in pharma, aiming to accelerate drug discovery, personalize medicine, and enhance manufacturing through unprecedented computational power.
Caffeine boosts sports performance but may impair sleep quality, especially when consumed later in the day. Individualized strategies balancing caffeine intake and sleep hygiene can optimize athlete performance and recovery.
A randomized crossover study in 20 men shows exercise‑induced oxidative stress alters erythrocyte redox and glycolytic metabolism, reduces 2,3‑BPG/ATP generation, and modestly impairs muscle oxygen extraction and arm exercise VO2peak, sugge
A randomized, placebo-controlled trial in highly trained male distance runners found 4 weeks of 1000 mg/day urolithin A reduced markers of muscle damage and perceived exertion and upregulated mitochondrial proteomic pathways, but did not pr
A groundbreaking study reveals that lifestyle changes improving fat distribution and insulin function can reverse prediabetes without weight loss, significantly cutting type 2 diabetes risk.
This article critically compares the efficacy, safety, and long-term outcomes of tirzepatide, semaglutide, and liraglutide for the treatment of obesity based on recent Cochrane systematic reviews, highlighting differences in weight loss, ad
A randomized trial shows that physical therapy and text message reminders do not significantly improve knee pain outcomes beyond a simple home exercise program in patients aged 45-85 with degenerative meniscal tears.
This study reveals significant shared genetic architectures between problematic alcohol use and various psychiatric disorders, identifying key genes like TTC12 and ANKK1 that may underlie their comorbidity.
This study reveals that higher handgrip strength is significantly associated with reduced risks of preclinical obesity progression and mortality, highlighting the importance of muscle strength in managing early obesity-related health risks.
Deceased donor kidney transplantation improves survival compared to dialysis waitlisting, with benefits varying by donor kidney quality and recipient age. Low-risk kidneys yield the greatest survival gains, particularly in older recipients.
