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Despite identical immunogenetic makeup, half of kidney transplant recipients from identical twins remain on calcineurin inhibitors, with no demonstrable benefit in rejection reduction or graft survival over 25 years, calling for critical re
Individualized coaching using EHR learner analytics significantly improves resident inbasket management efficiency and feedback quality but does not reduce perceived burnout or improve confidence.
The ANDROMEDA phase 3 trial demonstrates that adding subcutaneous daratumumab to VCd therapy markedly improves hematologic and organ responses, leading to better progression-free and overall survival in newly diagnosed AL amyloidosis patien
This study analyzes healthcare usage up to 12 months after COVID-19 infection, revealing prolonged increased utilization—especially among hospitalized patients—highlighting ongoing care needs for survivors.
Alpha-1 antitrypsin deficiency (AATD) Z-allele carriers, including heterozygotes and homozygotes, exhibit progressively increased risk of adverse liver outcomes, emphasizing the need for early diagnosis and vigilant monitoring.
A shift from static portal pressure thresholds to dynamic, non-invasive risk prediction models offers improved prognostic accuracy for decompensation in advanced chronic liver disease, enabling personalized patient management and better cli
The DASH4D diet, a tailored DASH-style intervention for diabetes, significantly improved key glycemic biomarkers including fructosamine, fasting glucose, and HbA1c compared to a typical American diet in adults with type 2 diabetes.
This study reveals distinct sex differences in skeletal muscle inflammation and dysfunction in patients with HFrEF, highlighting divergent immune cell profiles linked to muscle mass and strength variations in men versus women, advancing und
A clear, clinician-focused summary of the 2025 VA/DoD guideline update: new screening thresholds, streamlined treatment pathways, integration of pharmacotherapy (including GLP‑1 receptor agonists), endoscopic and surgical options, and veter
Following the 2018 MISSION Act expansion, VA specialty referrals and community care outsourcing increased substantially without reducing outpatient specialty wait times, signaling the need for alternative access-improvement strategies.
This study identifies baseline frailty, organ dysfunction severity, and corticosteroid use as independent predictors of severe post-intensive care frailty in older septic shock survivors, highlighting critical factors for targeted post-ICU
This study found that patient-physician sex concordance does not influence diagnostic accuracy in primary care, but female physicians consistently outperform male counterparts in diagnosing complex conditions such as POTS and syphilis, high
This study highlights that geriatric vulnerabilities and comorbidities, once considered nonmodifiable, play a dominant role in 30-day readmissions after colorectal surgery in older adults, emphasizing the need for integrated perioperative i
Randomized Quality Improvement (RQI) trials offer robust evidence for healthcare interventions but raise ethical and regulatory challenges. A proposed framework provides streamlined oversight enabling safer, evidence-based care improvements
This qualitative study reveals that patients undergoing pulmonary function tests face emotional and informational challenges. A co-developed educational pamphlet improves understanding and may reduce anxiety, highlighting the need for patie
Histidine-rich glycoprotein (HRG) directly modulates platelet adhesion and aggregation by binding platelet receptors GPIbα and GPIIb/IIIa, competing with key ligands VWF and fibrinogen, thus attenuating thrombus formation; reduced HRG in se
Bempedoic acid reduces the risk of major adverse limb and cardiovascular events in statin-intolerant patients with peripheral artery disease, illustrating its potential to enhance vascular risk management.
This study highlights how unmet transportation needs significantly increase missed in-person primary care appointments, while telemedicine offers a viable solution to overcome these barriers, improving healthcare access.
Changes in NT-proBNP levels over three years define heart stress status, which improves cardiovascular and mortality risk prediction in older adults without prior CVD, underscoring its utility in clinical risk stratification.
This study evaluates how ICU room characteristics, including room type and visibility, influence mortality and length of stay, finding single rooms increase length of stay without affecting mortality.
