Internal Medicine
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Ethosuximide Fails to Relieve IBS-Related Abdominal Pain: Results from a Multicenter Randomized Controlled Trial
A multicenter RCT found that ethosuximide, a T-type calcium channel blocker, did not improve abdominal pain in IBS patients compared to placebo and was associated with significant tolerability issues, highlighting the need for more selectiv
Beyond the Hospital Walls: Can Prospective Audit and Feedback Solve the Discharge Antibiotic Dilemma?
A multicenter stepped-wedge trial reveals that while prospective audit and feedback by stewardship teams improves the quality of discharge antibiotic prescribing, it fails to reduce the overall volume or duration of therapy, highlighting th
Opportunistic Genomic Screening for Familial Hypercholesterolemia: Does Genetic Feedback Drive Clinical Change?
This randomized clinical trial investigates whether returning opportunistic genomic results for familial hypercholesterolemia to veterans impacts LDL-C levels. While the primary endpoint missed statistical significance, the findings suggest
Taladegib Shows Potential to Improve Lung Function in Idiopathic Pulmonary Fibrosis: Results from the ENV-IPF-101 Phase 2a Trial
The Phase 2a ENV-IPF-101 trial demonstrates that taladegib, a Hedgehog pathway inhibitor, not only stabilizes but may improve forced vital capacity and reduce fibrotic burden in patients with idiopathic pulmonary fibrosis over 12 weeks.
Resveratrol and Type 2 Diabetes: Does the Red Wine Compound Really Control Blood Sugar?
A rigorous clinical trial reveals that five weeks of resveratrol supplementation does not improve blood sugar, GLP-1 levels, or gastric emptying in patients with type 2 diabetes.
Dietary Phytomix Dibifree Reshapes T2D Management by Modulating the Gut-Pancreas-Adipose-Immune Axis
A randomized trial demonstrates that Dibifree, a novel dietary phytomix, improves HbA1c and adiposity in T2D patients by enhancing GLP-1 activity and modulating immune responses.
The Planetary Health Diet: A Nutritionally Superior Strategy for Both People and Planet
A large-scale analysis of UK dietary data reveals that higher alignment with the EAT-Lancet planetary health diet significantly improves the intake of essential micronutrients like iron, zinc, and calcium, refuting concerns that sustainable
Beyond the Oral Cavity: Probiotic Adjuncts in Periodontitis Yield Systemic Glycemic Benefits for Diabetic Patients
A randomized clinical trial reveals that while Limosilactobacillus reuteri probiotics do not enhance local periodontal healing compared to standard therapy, they significantly improve systemic glycemic control (HbA1c) in patients with diabe
Beyond the High-Protein Hype: Why Moderate Diets May Be the Secret to Reversing Prediabetes
A major long-term trial reveals that a moderate-protein, moderate-glycaemic index diet is more effective for sustaining prediabetes remission than high-protein alternatives, regardless of total weight loss.
Modulating Starch Digestibility: A Practical Strategy for Optimizing Glycemic Variability in Type 2 Diabetes
A 12-week randomized controlled trial demonstrates that prioritizing slowly digestible starch (SDS) through dietary and culinary counseling significantly reduces glycemic variability and helps patients with type 2 diabetes achieve target Hb
Breaking the C-Peptide Barrier: New Evidence Shows Automated Insulin Delivery Benefits All Adults with Type 2 Diabetes
A landmark study reveals that automated insulin delivery systems significantly improve blood sugar control for adults with type 2 diabetes, regardless of their C-peptide levels, challenging current insurance restrictions that limit access t
2025 FDA Drug Approvals: A Critical Review of New Therapeutic Frontiers and Regulatory Shifts
A comprehensive analysis of the 46 novel drugs approved by the FDA in 2025, highlighting breakthroughs in oncology, chronic pain, and respiratory medicine, alongside significant regulatory changes and a preview of the 2026 pipeline.
The 42-Hour Window: Why Delaying Dual Antiplatelet Therapy Compromises Outcomes in Minor Stroke and High-Risk TIA
A large-scale cohort study demonstrates that the efficacy of dual antiplatelet therapy for minor stroke and TIA is highly time-dependent, with maximal benefits seen within 24 hours and a loss of therapeutic effect after approximately 42 hou
Multicomponent Nudges Significantly Boost Influenza Vaccination Rates in Primary Care: Insights from the BE IMMUNE Trial
The BE IMMUNE randomized trial demonstrates that combining patient text reminders, clinician EHR pended orders, and peer comparisons increases flu vaccination by 5.1 percentage points among adults aged 50 and older, highlighting the efficac
Age-Adjusted D-Dimer Cutoffs Safely Rule Out Deep Vein Thrombosis: Results from the ADJUST-DVT Trial
The ADJUST-DVT study confirms that an age-adjusted D-dimer cutoff (age × 10 µg/L) safely increases the number of patients in whom deep vein thrombosis can be ruled out without imaging, particularly benefiting patients over 75 years of age.
Low Potassium Levels Linked to Five-Fold Increase in Daily Atrial Fibrillation Risk: Insights from Continuous Monitoring
A post hoc analysis of the LOOP study reveals that hypokalaemia is significantly associated with an increased risk of daily atrial fibrillation, particularly longer episodes. The study highlights that deviations from a patient’s individual
Lowering Blood Pressure in Isolated Diastolic Hypertension: Evidence Supports Risk Reduction Across All Diastolic Levels
A large-scale meta-analysis reveals that lowering blood pressure in patients with isolated diastolic hypertension (IDH) provides cardiovascular protection comparable to those with systolic elevations, suggesting that diastolic thresholds al
Safety Profile Favors Apixaban Over Rivaroxaban in High-Risk Patients with Atrial Fibrillation and Peripheral Artery Disease
A large-scale cohort study reveals that while rivaroxaban and apixaban offer similar protection against limb events and stroke in patients with AF and PAD, rivaroxaban is associated with a 55% higher risk of major bleeding, suggesting apixa
Beyond Standard Risk Factors: High-Sensitivity C-Reactive Protein as a Critical Driver of Cardiovascular Risk Prediction
Recent large-scale studies demonstrate that high-sensitivity C-reactive protein (hsCRP) is a potent, stable predictor of cardiovascular events, even in individuals without traditional risk factors. Despite its clinical utility in improving
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