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This study reveals that copeptin kinetics remain mostly intact in healthy aging, but older adults exhibit diminished copeptin suppression after hydration, potentially explaining their increased vulnerability to hyponatremia.
This article explores primary care providers’ perspectives on real-time benefit tools (RTBTs) embedded in electronic health records, highlighting their potential for cost-conscious prescribing amidst challenges like incomplete data an
Experience-based continuous glucose monitoring (CGM) curricula significantly improve internal medicine residents’ confidence in applied patient care skills compared to traditional approaches, supporting hands-on CGM training integrati
Cryptogenic steatotic liver disease (SLD) is a form of fatty liver disease found in lean individuals without diabetes or other metabolic risk factors, associated with significant liver injury and increased mortality risk.
The STATICH trial assessed safety and efficacy of antiplatelet therapy after intracerebral hemorrhage, revealing increased hemorrhagic risk but fewer ischemic events among treated patients, highlighting ongoing clinical dilemmas.
This study emulated a target trial to compare ultra-early (0-3h) versus early (>3-6h) vasopressin initiation after norepinephrine escalation in septic shock, revealing significant mortality and renal therapy benefits with ultra-early use
A novel longitudinal obesity medicine training pathway for internal medicine residents, implemented at an urban Federally Qualified Health Center, improves physician confidence and management skills in obesity care, preparing trainees for b
A national survey reveals that general internal medicine research fellowships are vital for developing research skills and careers but face challenges including training gaps and recruitment difficulties.
This study evaluates the real-world effectiveness and safety of direct oral anticoagulants versus warfarin in Asian patients with atrial fibrillation and mitral stenosis, revealing higher stroke yet lower myocardial infarction risk with DOA
Excess folic acid promotes erythropoiesis impairment in myelodysplastic neoplasms via the FOLR2-IRF2BP2 axis, revealing potential therapeutic targets involving dietary folic acid restriction and pathway inhibition.
This study investigates whether recurrent hospitalizations mediate the association of postoperative delirium with long-term cognitive decline in seniors after major surgery, finding that rehospitalization does not significantly affect this
The American College of Physicians’ 2026 position paper calls for comprehensive payer coverage, healthy food access, bias reduction, and research to tackle adult obesity through multisector public policy.
A large retrospective study from Pakistan shows that LACE and HOSPITAL scores have fair accuracy in predicting 30-day readmissions among internal medicine patients, supporting their use in LMIC hospitals to target interventions and improve
Biallelic loss-of-function mutations in BPNT1 are identified as a new genetic cause of vitamin B12-dependent megaloblastic anemia, linked to disrupted ribosome biogenesis and impaired ileal vitamin B12 absorption in mouse models.
A structured discharge curriculum for sub-internship medical students significantly improves their discharge instruction skills and knowledge, positively influencing patient-reported understanding of urgent care instructions after hospital
This multicenter study evaluates autologous stem cell transplantation (ASCT) in POEMS syndrome, showing significant hematologic response, durable survival, and manageable toxicity, highlighting ASCT’s pivotal role in treatment.
Rapid skeletal muscle loss occurs in a significant subset of cirrhosis patients and independently predicts waitlist mortality, highlighting sarcopenia as a critical therapeutic target in liver disease management.
This study reveals that Asian Indians with prediabetes or type 2 diabetes show significantly higher liver and abdominal fat despite similar BMI, highlighting liver fat’s key role in dysglycaemia and the importance of early interventio
A large study in veterans with type 2 diabetes found that adding GLP-1 receptor agonists to basal insulin did not improve insulin discontinuation rates compared to SGLT-2 inhibitors or DPP-4 inhibitors over three years.
A machine learning model using electronic health records effectively identifies patients at high risk of atrial fibrillation, enabling targeted screening and early diagnosis to prevent stroke.
