Section
Genetic susceptibility to metabolic dysfunction-associated steatotic liver disease (MASLD) is amplified by gut microbiota interactions, with ceramides playing a key role; targeted microbial interventions can reverse hepatic injury in at-ris
A national cohort study reveals significant gaps in the diagnosis and pharmacologic treatment of adults with laboratory-confirmed diabetes, highlighting the impact of glycemic severity and comorbidities on care delivery.
This article explores leadership perspectives on equity in Hospital at Home (HaH) programs, highlighting strategies to broaden access, eliminate enrollment barriers, and address health disparities for more equitable acute care delivery.
This study compares PSA screening and biopsy rates between Veterans Affairs and Fee-for-Service Medicare, revealing that VA care is more closely aligned with patients’ likelihood of benefit, particularly in older men and those with li
This study evaluates large language model (LLM) performance for predicting same-day hospital discharge, identifies primary error sources, and demonstrates that automated prompt optimization significantly improves predictive accuracy.
This study evaluates trauma-informed care (TIC) knowledge, attitudes, and practices among medical students and clinical instructors, revealing differences linked to training stages and lived adversity, highlighting opportunities for improve
Butyrylcholinesterase (BuChE) modulates hepatic stellate cell activation by degrading acetylcholine, mitigating fibrogenesis via muscarinic receptor signaling and offering a new therapeutic target for liver fibrosis.
Declines in frailty, intrinsic capacity, and physical quality of life occur years before cardiovascular events, highlighting a prolonged window for early intervention in older adults.
This study employs Item Response Theory to reveal that while overall communication scores in virtual and in-person OSCEs are similar, specific communication items like explaining jargon differ in proficiency thresholds across modalities, un
This article evaluates strategies for interpreting consecutive aldosterone-to-renin ratio tests in primary aldosteronism diagnosis, highlighting the diagnostic trade-offs and guiding clinical decision-making based on discordant or concordan
Extremely high NT-proBNP levels in hospitalized patients often indicate infection rather than heart failure, with a high mortality risk; interpretation requires comprehensive clinical context.
This qualitative study explores how internal medicine clinicians develop skills in discussing goals of care, revealing a progression from basic understanding to advanced, integrated communication approaches, and underscores the need for str
A concise, clinician-friendly summary of the 2026 VA/DoD guideline for treating tobacco and nicotine use, focusing on evidence-based pharmacotherapy, counseling, and new recommendations for electronic and smokeless products.
This multinational study reveals that specific gut microbiome profiles significantly correlate with 90-day hospitalisation risk in cirrhosis, enhancing prognostic accuracy beyond clinical features alone.
Between 2015 and 2025, non-cystic fibrosis bronchiectasis prevalence in the US primary care population increased by 133%, predominantly affecting older, white, female patients with Medicare coverage.
This statewide cohort study reveals significantly higher incidence and earlier onset of systemic physical multimorbidity among people with schizophrenia-spectrum or bipolar disorders compared to matched controls, highlighting urgent needs f
A nationwide survey of hospitalists reveals varied beliefs regarding treatment thresholds and approaches for asymptomatic elevated blood pressure in hospitalized patients, highlighting clinical uncertainty and practice variation.
A large-scale EHR study reveals a 133% increase in non-cystic fibrosis bronchiectasis prevalence in U.S. adults from 2015 to 2025, with marked demographic disparities.
Escalation of antihypertensive treatment in expectant management of early-onset preeclampsia with severe features correlates with increased maternal adverse outcomes, suggesting treatment trajectory as a dynamic risk indicator.
This qualitative study explores barriers and facilitators to implementing medical-legal partnerships (MLPs) for veterans experiencing intimate partner violence (IPV) within the Veterans Health Administration, highlighting critical organizat
