Internal Medicine
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324 articles · 20 / page
Angiographic Burden of Coronary Atherosclerosis: The Critical Mediator Between ASCVD Risk Factors and Cardiovascular Outcomes
This Mendelian randomization study reveals that coronary plaque burden significantly mediates the link between traditional risk factors and adverse events like myocardial infarction and heart failure, reinforcing the necessity of early prim
Restrictive Physiology, Not Systolic Failure, Defines the Clinical Landscape of Cardiac Amyloidosis
A large-scale study identifies restrictive physiology as the dominant phenotype in cardiac amyloidosis. While preserved function offers better survival, rapid progression to restriction underscores the importance of early diagnosis and moni
Ensitrelvir Demonstrates Potent Antiviral Efficacy Comparable to Nirmatrelvir in Early COVID-19: Insights from the PLATCOV Trial
The PLATCOV trial identifies ensitrelvir as a highly effective oral antiviral, achieving rapid SARS-CoV-2 clearance comparable to ritonavir-boosted nirmatrelvir. This phase 2 adaptive trial suggests ensitrelvir is a viable alternative for o
Minocycline Significantly Improves Functional Recovery in Acute Ischaemic Stroke: Evidence from the EMPHASIS Trial
The EMPHASIS trial reveals that oral minocycline initiated within 72 hours of an acute ischaemic stroke significantly enhances functional independence at 90 days. This multicentre study provides robust evidence for a well-tolerated, accessi
Preventing Epilepsy After Stroke: Insights from the Eslicarbazepine Acetate Phase 2a Trial
The BIA-2093-213 trial evaluated eslicarbazepine acetate for preventing post-stroke epilepsy. While the primary endpoint was not met due to being underpowered, the study establishes a feasible framework for future antiepileptogenesis resear
Proactive Pharmacist Outreach Slashes Hypoglycemia Risk and Optimizes Prescribing in High-Risk Type 2 Diabetes
This randomized clinical trial demonstrates that proactive pharmacist outreach using evidence-based algorithms significantly improves prescribing safety and reduces emergency hypoglycemia events in high-risk patients with type 2 diabetes wi
Albumin Replacement in Septic Shock: Safety Confirmed but Survival Benefit Remains Elusive
The ARISS randomized clinical trial found that 20% albumin supplementation to maintain serum levels ≥3.0 g/dL is safe in septic shock but does not significantly improve 90-day survival compared to standard crystalloids, though the study’s e
Metformin Fails to Improve Walking Performance in Peripheral Artery Disease: Results of the PERMET Randomized Trial
The PERMET randomized clinical trial found that metformin did not improve the 6-minute walk distance or secondary walking outcomes in patients with peripheral artery disease without diabetes, suggesting no benefit for functional impairment
Predicting the Tumble: Recurrent Fall History and Dual-Task Impairment Emerge as Primary Risk Factors in COPD
A new clinical prediction model identifies prior recurrent falls, multimorbidity, and impaired dual-task mobility as key predictors of future falls in patients with COPD, offering a new tool for targeted geriatric intervention in respirator
Pharmacist-Led Patient Self-Testing Superior to Usual Care for Warfarin Management in Mechanical Heart Valve Patients: Evidence from a Multicentre RCT in China
A multicentre RCT in China found that pharmacist-led patient self-testing (PST) significantly improves time in therapeutic range and reduces major bleeding and thromboembolism in patients with mechanical heart valves compared to traditional
Sibeprenlimab Achieves 51% Reduction in Proteinuria for IgA Nephropathy: Key Interim Insights from the Phase 3 VISIONARY Trial
The Phase 3 VISIONARY trial interim analysis demonstrates that sibeprenlimab, a monoclonal antibody targeting APRIL, significantly reduces proteinuria and pathogenic IgA1 in patients with IgA nephropathy, offering a promising upstream thera
Produce Prescriptions Alone Fail to Improve Diabetes Outcomes: Lessons from a Major Pragmatic Trial
A large-scale randomized trial reveals that monthly produce subsidies do not significantly improve HbA1c or reduce healthcare utilization in food-insecure diabetes patients, suggesting that ‘Food is Medicine’ initiatives require more than j
Is the Planetary Health Diet Nutritious Enough? New Evidence from a Swedish Population Study
A large-scale Swedish study evaluates the nutritional adequacy of the EAT-Lancet diet. Findings suggest it provides sufficient micronutrients for most, though women may face an increased risk of anemia, highlighting the need for careful die
Predicting the Path to Dementia: Five-Year Progression from Mild to Major Vascular Cognitive Impairment Following Ischemic Stroke
A five-year prospective study reveals that 13.6% of stroke patients with mild cognitive impairment progress to major VCI, identifying age, diabetes, atrial fibrillation, and small vessel disease as key predictors for long-term cognitive dec
Rapid Remission and Low Disease Activity: Real-World Evidence for Anifrolumab in Systemic Lupus Erythematosus
Interim data from the multicentre REVEAL study demonstrate that anifrolumab facilitates rapid disease control in real-world SLE patients, with 66% achieving low disease activity within six months, particularly in those with mucocutaneous an
Monthly Efimosfermin Alfa Demonstrates Safety and Tolerability in MASH-Related Fibrosis: Insights from a Phase 2 Trial
The Phase 2 trial of efimosfermin alfa (BOS-580) shows that once-monthly dosing is safe and well-tolerated in patients with MASH and F2/F3 fibrosis, supporting its continued clinical development as a potential liver-targeted therapy.
Challenging the Label: Large-Scale Meta-Analysis Refutes Most Statin-Attributed Adverse Effects
A comprehensive meta-analysis of double-blind RCTs by the CTT Collaboration reveals that the majority of adverse effects listed on statin labels, including cognitive and sleep issues, lack causal evidence, suggesting a need for urgent regul
Delirium as a Sentinel Event: New UK Biobank Data Links Acute Brain Failure to Decades of Multisystem Vulnerability
A large-scale matched cohort study from the UK Biobank identifies in-hospital delirium as a sentinel marker for long-term multisystem vulnerability. Associated with increased risks of sepsis, AKI, and falls, delirium signals a profound phys
Cumulative Geriatric Syndrome Burden: A Potent Predictor of 90-Day Mortality in Hospitalized Older Adults
A large multicenter cohort study demonstrates that the number of geriatric syndromes at hospital admission is independently and incrementally associated with 90-day mortality, suggesting that cumulative geriatric burden is a critical progno
Beyond Pediatric Survival: The Disproportionate Impact of Childhood-Onset Complex Chronic Conditions on Adult Hospital Systems
This study reveals that young adults with childhood-onset complex chronic conditions (4Cs) account for over 10% of hospital bed-days despite being a small patient volume. They face longer stays, higher costs, and frequent readmissions, high
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