Gastroenterology
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Improving Sleep Quality through Cognitive Behavioural Therapy Alters Food Preferences in Adults with Overweight and Obesity
Cognitive behavioural therapy for insomnia enhances self-reported sleep quality and duration, reduces cravings for sweet and savoury foods, and shifts implicit food preferences in adults with overweight or obesity, though dietary intake cha
Intermittent Fasting vs Low-Calorie Diet in Managing Metabolic-Associated Fatty Liver Disease: Comparative Effects on Inflammation, Lipids, Glycemic Control, and Liver Fibrosis
This RCT compares 16:8 intermittent fasting and low-calorie diets in MAFLD patients, revealing both improve liver enzymes and anthropometrics, but low-calorie diet shows superior reduction in liver steatosis, fibrosis, and triglycerides.
Afimkibart, an Anti-TL1A Antibody, in Moderately-to-Severely Active Ulcerative Colitis: Insights from the Phase 2b TUSCANY-2 Trial
The TUSCANY-2 phase 2b trial evaluated afimkibart, a novel anti-TL1A antibody, in moderately-to-severely active ulcerative colitis, demonstrating favorable safety and clinically meaningful remission rates using modified Mayo scores despite
Comparative Efficacy of Low FODMAP Plus Traditional Dietary Advice, Low-Carbohydrate Diet, and Pharmacological Treatment in Moderate-to-Severe IBS: Insights from the CARIBS Trial
The CARIBS trial shows that both low FODMAP plus traditional dietary advice and a low-carbohydrate diet outperform optimized pharmacologic treatment in reducing IBS symptom severity after 4 weeks, highlighting the importance of dietary inte
Early Control of Ulcerative Colitis and Its Impact on Long-Term Outcomes: Insights from the UNIFI Phase 3 Study
Achieving disease clearance early after induction therapy with ustekinumab in ulcerative colitis patients predicts sustained clinical remission, symptom control, and improved quality of life over four years.
Pathobionts in Colorectal Tumour Microbiota: Predicting Survival and Shaping Oncological Outcomes
This study identifies specific pathobiont bacterial clusters in colorectal tumour microbiota that predict disease-free survival post-surgical resection, linking microbial and metabolic profiles to colorectal cancer prognosis.
Silymarin in Clinical Medicine: A Decade of Therapeutic Advances and Future Disease Targets
Comprehensive review of recent decade research on silymarin elucidates its antioxidant, anti-inflammatory, and hepatoprotective effects, highlighting promising clinical applications in metabolic diseases, neurodegeneration, liver disorders,
HTD1801 Shows Promising Histologic Improvement in Metabolic Dysfunction-Associated Steatohepatitis: Insights from Preclinical and Phase 2 Clinical Studies
HTD1801 (berberine ursodeoxycholate) significantly improves liver histology and reduces fibrosis in metabolic dysfunction-associated steatohepatitis (MASH) as demonstrated by preclinical models and a Phase 2 trial.
Daily Coffee: A Natural Ally Against Liver Damage? Exploring the Science Behind the Buzz
Emerging research suggests that drinking a daily cup of coffee could reduce the risk of liver damage by up to 30%, offering new hope in liver health management.
Understanding Intestinal Polyps: When Should They Be Removed?
Intestinal polyps are common findings during colonoscopy, especially among those older than 50. While most are benign, certain types carry a significant risk of progressing to colorectal cancer. This article explores polyp types, risk facto
Berberine Demonstrates Long-Term Prevention of Colorectal Adenoma Recurrence: A Six-Year Follow-Up Study
Berberine shows sustained efficacy and safety in reducing colorectal adenoma recurrence and neoplasm occurrence after polypectomy, providing new directions for secondary prevention of colorectal cancer.
Butyrate-Producing Clostridium butyricum: A Direct Interactor with Colorectal Cancer Cells that Reverses Immune Suppression and Enhances Checkpoint Inhibitor Efficacy
Recent research uncovers that the probiotic Clostridium butyricum directly interacts with colorectal cancer cells to inhibit immune suppression via the secD-GRP78 axis, restoring CD8+ T cell antitumor function and enhancing PD-1 inhibitor t
Antibiotic Exposure as a Major Risk Factor for Clostridioides difficile Infection: Evidence from a Large Israeli Cohort and Systematic Reviews
Recent research confirms that antibiotic exposure doubles the risk of hospital-onset Clostridioides difficile infection (CDI), especially in non-carriers, underscoring the central role of antibiotic stewardship and the need for additional p
Anti-Inflammatory Dietary Education Reduces Frailty in Colorectal Cancer Patients: Insights from a 12-Week Randomized Controlled Trial
A 12-week anti-inflammatory dietary education significantly improved frailty, nutritional status, inflammatory biomarkers, and quality of life in frail colorectal cancer patients undergoing chemotherapy.
Cyclosporin Therapy: A Promising Rescue Treatment for Severe Steroid-Refractory Ulcerative Colitis
Cyclosporin demonstrated high clinical response rates in adults with severe steroid-refractory ulcerative colitis, allowing over half to avoid colectomy and highlighting its role as an effective rescue therapy.
Five-Year Outcomes of Per-Oral Endoscopic Myotomy vs. Laparoscopic Heller’s Myotomy Plus Dor Fundoplication in Idiopathic Achalasia
A multicenter randomized trial shows POEM is non-inferior to LHM plus Dor fundoplication for achalasia symptom control at 5 years, with differing reflux profiles.
Durable Remission and Safety of Upadacitinib in Moderate to Severe Ulcerative Colitis: Insights from the Phase 3 U-ACTIVATE Long-Term Extension Interim Analysis
Interim data from the U-ACTIVATE study demonstrate sustained clinical and endoscopic remission and a consistent safety profile for upadacitinib up to 3 years in moderate to severe ulcerative colitis.
Endoscopic Ultrasound-Guided Gastroenterostomy Reduces Reintervention in Malignant Gastric Outlet Obstruction: Insights from the Multicentre DRA-GOO Trial
A multicentre RCT demonstrated that endoscopic ultrasonography-guided gastroenterostomy (EUS-GE) significantly lowers 6-month reintervention rates and improves gastric outlet obstruction symptoms compared to duodenal stenting in unresectabl
Etrasimod in the Management of Eosinophilic Oesophagitis: Promising Results from the VOYAGE Phase 2 Trial
The VOYAGE phase 2 trial demonstrated that etrasimod, an oral S1P receptor modulator, significantly reduces oesophageal eosinophilic inflammation and improves endoscopic findings in adults with eosinophilic oesophagitis, with a favorable sa
Examining the Role of Gluten and Wheat in Irritable Bowel Syndrome: Insights from a Double-Blind, Sham-Controlled Crossover Trial
A rigorous trial reveals that perceived symptom worsening from gluten or wheat in IBS patients may largely be driven by expectation rather than the substances themselves, underscoring the importance of distinguishing true sensitivities from
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