Gastroenterology
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Appendicectomy Plus Medical Therapy Significantly Reduces Relapse in Ulcerative Colitis: Insights from the ACCURE Trial
The ACCURE trial demonstrates that laparoscopic appendicectomy combined with standard medical therapy significantly lowers 1-year relapse rates compared to medical therapy alone in ulcerative colitis patients in remission.
AI in Colonoscopy: Enhancing Detection or Eroding Physician Skills?
The integration of AI in colonoscopy improves adenoma detection but raises concerns about declining physician skills when AI support is withdrawn, highlighting a potential clinical ‘de-skilling’ effect.
Dapagliflozin Shows Promising Benefits for Patients with Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Landmark Multicentre Trial
Dapagliflozin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis outcomes without increasing adverse events, according to a rigorous 48-week randomized trial.
Four Typical Early Signs of Colorectal Cancer: What to Watch For
Colorectal cancer often shows subtle bowel changes early. Know the four warning signs—diarrhea, constipation, altered stool shape, and rectal bleeding—and when to seek screening and treatment.
Therapist-Guided Internet CBT Cuts Bulimia Episodes: A Japanese Randomized Trial with Promising Clinical Implications
A multicenter randomized trial in Japan found that a 12-week therapist-guided internet-based CBT program significantly reduced weekly bingeing and compensatory episodes in women with bulimia nervosa versus usual care (adjusted mean differen
Intermittent Calorie Restriction: A Promising Dietary Strategy for Metabolic Dysfunction-Associated Steatotic Liver Disease
Recent trials show intermittent calorie restriction (ICR) significantly reduces liver fat content in MASLD and NAFLD, especially in obese patients, offering an effective and well-tolerated alternative to conventional diets.
Pomegranate Peel Extract: A Promising Adjunct in Non-Alcoholic Fatty Liver Disease Management?
A double-blind RCT suggests pomegranate peel extract may improve liver enzymes, lipid profile, and inflammation in NAFLD patients, but does not significantly alter liver steatosis grade.
Flaxseed Powder Supplementation: Emerging Evidence in Non-Alcoholic Fatty Liver Disease and Metabolic Health
Flaxseed powder supplementation shows promise in improving liver fat, lipid metabolism, and inflammation in NAFLD and related metabolic disorders, with effects on gut microbiota but limited synergism with fasting mimicking diets.
The Effect of Chitosan Supplementation on Liver Function, Hepatic Steatosis Predictors, and Metabolic Indicators in Adults with Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
This clinical trial evaluates chitosan supplementation’s impact on liver health and metabolic markers in adults with NAFLD, showing potential benefits alongside a low-calorie diet.
Empowering Community Liver Health: Insights from the LOCATE-NAFLD Trial on Nurse-Led MASLD Screening
The LOCATE-NAFLD trial demonstrates that nurse-delivered, community-based liver screening is highly acceptable and effective for identifying high-risk MASLD patients, but faces challenges in sustainable adoption.
Mediterranean Diet Combined with Early Time-Restricted Feeding: A Promising Strategy for MASLD – Insights from the CHRONO-NAFLD Trial
A 12-week hypocaloric Mediterranean diet with early time-restricted feeding improved glycaemic control and cardiometabolic risk in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) compared to unrestricted timin
One Year of Gluten-Free Diet Impacts Gut Function and Microbiome in Celiac Disease
A study reveals that one year of a gluten-free diet partially improves gut function and microbiome composition in celiac disease but does not fully restore them to normal levels.
Understanding Liver Cysts: Are They Dangerous?
Explore liver cysts, their causes, symptoms, risks, treatment, and prevention strategies to demystify this common condition.
Maintaining Hunger Sensation to Delay Aging
Research indicates that the sensation of hunger triggered by calorie restriction can influence gene expression, helping to delay aging and extend lifespan by up to 35%.
Explainable Artificial Intelligence for Predicting Refractory Ulcerative Colitis: Insights from a Japanese Nationwide Registry
A machine learning model using nationwide registry data accurately predicts long-term remission in refractory ulcerative colitis and identifies key prognostic factors such as pseudopolyps.
Consecutive Fecal Microbiota Transplantation in MASLD: Insights from a Double-Blind Randomized Controlled Trial
A double-blind RCT found that three consecutive fecal microbiota transplantations did not significantly improve hepatic steatosis or metabolic parameters in patients with MASLD, suggesting patient selection based on microbiota diversity may
Low-Dose Hydrocortisone in Cirrhotic Patients With Septic Shock: A Double-Blind Randomised Placebo-Controlled Trial
This trial evaluated low-dose hydrocortisone in cirrhotic patients with septic shock, finding no improvement in 28-day mortality or shock resolution compared to placebo.
Waist Size Proves Key to Assessing Liver Health
Waist circumference is a superior predictor of metabolic liver diseases, outperforming BMI and other body metrics in assessing MASLD, MASH, and liver stiffness risks.
Perinatal Antibiotic Exposure Alters Neonatal Gut Microbiota in Preterm Infants: Clinical Implications for Infection Risk and Microbial Maturation
Perinatal antibiotic exposure in preterm infants disrupts gut microbiota composition, increasing pathogenic bacteria and reducing beneficial species, with implications for infection risk and the protective role of breastfeeding.
Probiotics and Prebiotics: Unlocking the Secrets of Gut Health and Immunity
Explore how probiotics and prebiotics fortify gut health, boosting immune response and overall well-being.
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