Family Medicine & Nutrition
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Enhancing Vagal Nerve Function with Multi-Species Probiotics: A Promising Therapeutic Avenue for Major Depression
A 3-month RCT demonstrates that multi-species probiotic supplementation improves vagal nerve function, gut microbiome composition, and sleep quality in patients with major depression, suggesting novel gut-brain axis interventions.
Synergistic Effects of Combined Aerobic and Resistance Exercise with Diet on Insulin Secretion and Neurotrophic Factors in Older Adults with Obesity
Combining aerobic and resistance exercise with diet-induced weight loss in older adults with obesity significantly improves insulin secretion, metabolic health, and physical function, likely mediated by ciliary neurotrophic factor receptor
Enhancing Metformin Efficacy and Tolerability in Prediabetes Through a Fermentable Carbohydrate-Rich Diet
A fermentable carbohydrate-enriched diet combined with metformin improves postprandial glycaemia, enhances GLP-1 secretion, and positively alters gut microbiota in prediabetic individuals, offering a personalized nutrition-pharmacology stra
Long-Term Outcomes of the DASH Intervention in Nonobstructive Coronary Artery Disease: Follow-Up of the DISCO-CT Study
A one-year DASH diet intervention led to sustained suppression of proatherogenic chemokine CXCL4 and fewer major cardiovascular events over six years despite reduced adherence and partial loss of initial benefits in nonobstructive CAD patie
Dose-Dependent Enhancement of L-Tryptophan-Induced Gut Hormone Secretion and Appetite Suppression by Intraduodenal Calcium in Obesity
Intraduodenal calcium at doses up to 1000 mg amplifies the anorexigenic effects of L-tryptophan by boosting gut hormones CCK, GLP-1, and PYY, reducing energy intake in obese males, highlighting a novel adjunctive approach for appetite regul
Decoding Metabolic Adaptation: Caloric Restriction’s Impact on Organ Size in the CALERIE 2 Trial
This study explores how caloric restriction influences organ size and metabolic adaptation, using MRI data from the CALERIE 2 trial, revealing nuanced changes in energy expenditure linked to organ-specific tissue loss.
Personalized Anti-Inflammatory Diet Modulates Gut Microbiome and Metabolome to Alleviate Osteoarthritis Pain
A 4-week anti-inflammatory dietary intervention in knee osteoarthritis patients led to targeted shifts in gut microbiota and metabolite profiles associated with significant pain reduction, highlighting the potential of microbiome-informed n
Impact of a Multifactorial Diet on ApoC-III, Ectopic Fat, and Beta Cell Function in Type 2 Diabetes: Insights from the MEDEA Study
The MEDEA randomized trial demonstrated that a multifactorial diet reduces plasma ApoC-III, correlates with decreased liver and pancreatic fat, and improves beta cell function in type 2 diabetes compared to a MUFA-rich diet.
The Dark Side of Olive Oil: High-Oil Diets Promote Lung Metastasis in Triple-Negative Breast Cancer
Recent research reveals that high-fat diets rich in olive oil, while not impairing immunity, significantly promote lung metastasis of triple-negative breast cancer via a novel fatty acid-driven mechanism involving FABP5 and ALDH pathways.
High-Protein Diet and Strength Training in Older Adults: No Adverse Impact on Oxidative Stress Markers
A 17-week randomized controlled trial demonstrates that a high-protein diet combined with strength training does not negatively affect oxidative stress markers in older adults, supporting their safe use to combat sarcopenia.
Timing Matters: Impact of Morning vs Afternoon High-Intensity Exercise on Inflammation and Glucose Control in Type 2 Diabetes
Afternoon high-intensity interval exercise improves post-exercise blood glucose and reduces inflammation more effectively than morning sessions in type 2 diabetes, highlighting circadian influences on exercise metabolism and benefits of mea
Nutritional Intervention in Chronic Heart Failure: Enhancing Functional Capacity and Nutritional Status without Major Clinical Outcome Impact
A prespecified subanalysis of the PACMAN-HF trial demonstrates that individualized nutritional interventions in chronic heart failure patients at risk of malnutrition improve nutritional status and functional capacity but do not significant
Prepregnancy Time-Restricted Eating and Exercise Training Do Not Improve Glycaemic Control in High-Risk Gestational Diabetes: Insights from the BEFORE THE BEGINNING Trial
A randomized trial investigating time-restricted eating and exercise before and during pregnancy found no significant improvement in glucose tolerance at 28 weeks gestation among individuals at elevated risk of gestational diabetes.
Dynamic Effects of Short-Term Dietary Energy Loads on Fecal Serotonin, Gut Microbiome Tryptophanase, and Energy Absorption: Insights from a Randomized Crossover Trial
Short-term alterations in dietary energy intake significantly impact fecal serotonin, gut microbiome tryptophanase activity, and energy absorption, highlighting a complex interaction that may influence metabolic health.
Early-Life Blueberry Consumption: Potential Benefits for Infant Allergy Resolution, Immune Modulation, and Gut Microbiome Development
Daily blueberry intake during complementary feeding may enhance allergy symptom resolution, favorably influence immune biomarkers, and promote beneficial gut microbiota shifts in breastfed infants, suggesting new avenues for allergy prevent
Unlocking Better Sleep: How Daily Walnut Consumption Enhances Melatonin Metabolism and Sleep Quality in Young Adults
A randomized crossover trial shows that daily intake of 40 g walnuts increases urinary 6-sulfatoxymelatonin, reduces sleep latency, and improves global sleep quality in young adults, highlighting walnuts’ potential as a natural sleep aid.
Metformin with or without Mediterranean Diet Significantly Reduces Diabetes Risk in Metabolic Syndrome: Insights from the MeMeMe Trial
The MeMeMe randomized trial shows that metformin 1,700 mg/day effectively prevents type 2 diabetes in metabolic syndrome patients, independent of Mediterranean diet adherence, with implications for age-related disease prevention.
How Micronutrients Have Shaped Human DNA: Insights from Global Genetic Adaptations
A recent study reveals how essential micronutrients like iron, calcium, and zinc influenced human evolution by driving genetic adaptations to environmental nutrient availability across populations worldwide.
The Ginger Miracle? Exploring the Anti-Aging Potential of Ginger and What the Science Really Says
Recent studies suggest a compound in ginger may clear half of aging cells in two days, but practical benefits and safety concerns warrant cautious optimism. Here’s a science-based look at ginger and aging.
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