Family Medicine & Nutrition
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Dietary Patterns and Intracranial Atherosclerosis Risk in Elderly Patients With Hypertension or Myocardial Infarction: An Evidence-Based Review
Healthy dietary patterns may reduce intracranial atherosclerosis severity in older adults with hypertension or prior myocardial infarction, suggesting diet’s conditional protective role in vascular brain disease.
APOE ε4 Allele: A Key Driver of Cognitive Decline and Neurodegeneration in Older Adults from the Democratic Republic of the Congo
This study reveals that the APOE ε4 allele is linked to increased dementia prevalence, cognitive deficits, brain atrophy, and plasma biomarkers of neurodegeneration in older adults in the DRC, emphasizing its critical role in African popula
Lifetime Walking Intensity and Duration Reduce Amyloid-β Accumulation in Alzheimer’s Disease: Insights from a Korean Longitudinal Cohort
A 4-year longitudinal study reveals that long-duration, high-intensity lifetime walking is associated with reduced amyloid-β accumulation in older adults, suggesting a neuroprotective effect when initiated early in life.
Evaluating Combined Mind-Body Exercise, Cognitive Training, and Nurse-Led Risk Factor Modification in Mild Cognitive Impairment: Insights from a Three-Arm Randomized Controlled Trial
A large RCT in primary care showed no significant cognitive benefits of a combined intervention integrating mind-body physical exercise, cognitive training, and nurse-led risk factor modification over nurse-led risk factor modification alon
Dietary Patterns and Dementia Risk: Insights from a Large UK Biobank Cohort Study
Higher adherence to Mediterranean, MIND, and Recommended Food Score diets is linked to reduced risk of all-cause dementia and Alzheimer disease, highlighting diet as a modifiable factor in dementia prevention.
Planetary Health and Plant-Based Diets: Reducing Type 2 Diabetes Risk in UK Adults
Higher adherence to the Planetary Health Diet Index, reflecting environmentally sustainable plant-based eating patterns, is strongly associated with reduced type 2 diabetes risk in UK Biobank participants, comparable or superior to other es
Comparative Effectiveness of PTSD Treatments in Primary Care: Insights from a Pragmatic Randomized Trial
A pragmatic trial comparing SSRIs and written exposure therapy in primary care PTSD treatment found similar effectiveness initially; switching to SNRI was superior to WET augmentation for SSRI nonresponders.
Harnessing Flavan-3-ols for Cardiovascular Health: Impacts on Blood Pressure and Endothelial Function
This systematic review and meta-analysis demonstrates that flavan-3-ol-rich foods significantly lower blood pressure and improve endothelial function, supporting their role in cardiovascular prevention, especially in individuals with elevat
Decoding the Rise in Early-Onset Cancer: Implications for Primary Care and Screening Strategies
Rising early-onset cancer incidence appears driven largely by increased diagnostic scrutiny and overdiagnosis rather than a true surge in disease, altering screening and management approaches in primary care.
Evaluating the Impact of Behavioral Economics on Food Processing Choices in Food Pantries Using the Nova Classification
A behavioral economics intervention in Minnesota food pantries did not significantly reduce the selection of ultra-processed foods nor increase unprocessed food selection among clients, underscoring the need for targeted strategies to impro
Preserving Bone Quality in Older Adults with Obesity Through Lifestyle Intervention: Insights from the LIMB-Q Trial
The LIMB-Q trial demonstrates that intensive lifestyle interventions combining weight management and exercise preserve bone quality in older adults with obesity, despite significant weight loss, highlighting a promising approach for mitigat
Integrating Fall Prevention in Primary Care Significantly Reduces Falls Among Rural Older Adults in China: Insights from the FAMILY Cluster RCT
A 12-month cluster randomized trial in rural China demonstrated that a fall prevention program integrated into primary health care significantly decreased fall risk among older adults, highlighting a scalable strategy for resource-limited s
Mediterranean Diet as Adjunct Therapy in Psoriasis: Insights from the MEDIPSO Randomized Clinical Trial
A 16-week Mediterranean diet intervention significantly reduced psoriasis severity and improved metabolic markers in patients with mild to moderate disease, suggesting diet’s role as adjunctive therapy in psoriasis management.
Soft Drink Consumption and Depression: The Gut Microbiome Connection, Especially Eggerthella
This analysis explores how soft drink consumption correlates with major depressive disorder (MDD), revealing gut microbiome alterations—particularly in Eggerthella abundance—that may mediate this association, highlighting potential interven
Circulating Nanoparticles and Carotenoids as Biomarkers of Rehabilitation Recovery in Parkinson’s Disease
Intensive treadmill rehabilitation in Parkinson’s disease alters the biochemical composition of circulating extracellular vesicle-like particles, particularly increasing carotenoid content, which correlates with improved gait parameters, hi
Do Oily Fish Intake Increase Pancreatic Cancer Risk?
This Mendelian randomization study reveals a surprising association between higher oily fish consumption and increased pancreatic cancer risk, highlighting new directions for dietary guidance and pancreatic disease prevention.
The Curious Scent of Feces: The Dual Identity and Health Secrets of Skatole
Explore skatole, a compound with a paradoxical aroma found in feces and perfumes, its role in gut health, disease indicators, and diverse applications from medicine to agriculture.
Consumer Misinterpretation of Dietary Supplement Labels: Implications for Public Health and Regulation
Consumers frequently misconstrue dietary supplement labels with structure/function claims as implying disease prevention or treatment benefits, underscoring the need for clearer regulatory standards to prevent misinformation.
Challenges and Insights in Sustaining Weight Loss: Evaluating Adaptive vs Static Support
A recent trial comparing adaptive, algorithm-driven telephone support with static monthly coaching found no significant difference in long-term weight loss maintenance, highlighting complexities in obesity treatment and the need for refined
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