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Elevated plasma pro-opiomelanocortin (POMC) levels accurately predict silent corticotroph adenomas (SCAs) among clinically non-functioning pituitary adenomas, offering a promising tool for diagnosis and monitoring.
This study evaluates teprotumumab’s effectiveness for thyroid eye disease in Japanese patients, revealing notable improvements in orbital inflammation and proptosis compared to intravenous glucocorticoid therapy with distinct MRI-base
The gain-of-function GLP1R R131Q variant slows β-cell decline and improves glycemic response to GLP-1 receptor agonists, highlighting its potential role in precision diabetes therapeutics.
A randomized controlled trial demonstrates that PTeye-guided near-infrared autofluorescence significantly improves identification and preservation of parathyroid glands during total thyroidectomy, reducing transient hypoparathyroidism, espe
This study maps apo AI glycation sites in diabetes, linking them to HDL dysfunction and diabetic atherosclerosis via RAGE-associated signaling, and demonstrates that glycation-resistant apo AI preserves HDL function and lessens atherosclero
Women with preconception hemithyroidectomy face a substantially increased risk of overt hypothyroidism during pregnancy, especially after thyroid cancer surgery, yet obstetric outcomes remain comparable to women with intact thyroids.
A novel protocol performing diagnostic 131I scans within 24 hours after the second rhTSH injection reliably guides radioiodine therapy in differentiated thyroid cancer, enabling same-cycle pre-treatment evaluation and treatment without sche
European experts recommend designated centers, structured diagnostic pathways, and real‑world monitoring to deliver precision therapies (MC4R agonists) safely and equitably to people with rare genetic forms of obesity.
A comprehensive European cohort study reveals that Helicobacter pylori infection’s association with insulin resistance is confounded by socioeconomic and lifestyle factors, arguing against its independent causal role and the need for
A longitudinal study shows no association between fecal short-chain fatty acid levels during pregnancy and early childhood with the progression to islet autoimmunity in children at risk for type 1 diabetes.
A phase 3 trial demonstrated that HTD1801 monotherapy significantly reduces HbA1c and improves cardiometabolic and inflammatory markers in patients with inadequately controlled type 2 diabetes, with sustained effects and a favorable safety
Iatrogenic hypercalcemia complicates 14% of hypoparathyroidism cases post-total thyroidectomy, linked to low early postoperative parathyroid hormone and early vitamin D initiation. Careful supplementation and monitoring are vital in prevent
This population-wide study demonstrates that parathyroidectomy in primary hyperparathyroidism reduces major adverse cardiovascular events risk, particularly in patients with higher serum calcium levels.
African adults with type 2 diabetes who are lean exhibit distinct complication profiles characterized by higher retinopathy and stroke risk but lower hypertension and cardiovascular disease risk compared to their overweight/obese counterpar
This article reviews data-driven diabetes subtypes in East Asians, highlighting unique pathological features, genetic influences, and complication risks, emphasizing personalized treatment strategies for optimized care.
Islet autoantibody positivity varies significantly among racial and ethnic groups and is influenced by socioeconomic deprivation, implicating tailored screening and prevention strategies for equitable diabetes care.
Early weight loss after impaired glucose tolerance diagnosis is linked to markedly reduced long-term risk of cardiovascular events and death, underscoring the importance of early lifestyle interventions in prediabetes management.
This study reveals how genetic risk for diabetic retinopathy can be significantly mitigated by healthy lifestyle choices, emphasizing universal behavioral interventions for prevention.
This article reviews challenges and management strategies for achieving pregnancy in women with 21-hydroxylase deficiency congenital adrenal hyperplasia, emphasizing hormonal normalization and individualized glucocorticoid therapy.
Octreotide shows potential as an effective adjunctive therapy in catecholamine-secreting pheochromocytomas and paragangliomas, improving biochemical, hemodynamic, and metabolic parameters and supporting perioperative management.
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