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This study reveals that copeptin kinetics remain mostly intact in healthy aging, but older adults exhibit diminished copeptin suppression after hydration, potentially explaining their increased vulnerability to hyponatremia.
A 6-month randomized controlled trial found that time-restricted eating (TRE) in adults with type 1 diabetes is safe and improves HbA1c levels but does not significantly reduce body weight compared to calorie restriction or no intervention.
Deep capillary plexus ischemia quantified by geometric perfusion deficit predicts earlier and higher risk of diabetic retinopathy complications than foveal avascular zone enlargement, underscoring GPDd’s clinical utility as a biomarke
This study reveals that distinct gestational diabetes mellitus (GDM) subtypes confer increased risks of prediabetes, diabetes, metabolic syndrome, and cardiovascular disease 10-14 years postpartum, underscoring the need for tailored long-te
This study quantitatively compares the direct healthcare costs of thyroid radiofrequency ablation (RFA) and hemithyroidectomy over one year, revealing cost advantages of RFA driven by reduced facility use, tempered by factors like repeat pr
Experience-based continuous glucose monitoring (CGM) curricula significantly improve internal medicine residents’ confidence in applied patient care skills compared to traditional approaches, supporting hands-on CGM training integrati
Medicare Advantage (MA) shows no significant improvement over original Medicare (OM) in managing type 2 diabetes outcomes or mitigating related social needs despite higher costs, underscoring the need for effective spending strategies.
A large Latin American study shows radiofrequency ablation is a safe, effective minimally invasive alternative for T1a low-risk papillary thyroid cancer, with excellent tumor disappearance rates and minimal complications over 18 months foll
This study reveals that reduced arginine availability during hyperglycaemia distinguishes A-β+ ketosis-prone diabetes from type 2 diabetes, implicating impaired arginine metabolism in ketoacidosis pathogenesis and highlighting citrulline su
Levothyroxine treatment in older adults with subclinical hypothyroidism shows limited impact on cardiometabolic biomarkers overall but may benefit those with higher TSH levels, highlighting nuanced treatment implications and the need for ta
This study reveals that housing instability among adults with uncontrolled diabetes is associated with increased financial strain and cost-related medication nonadherence, underscoring the need for holistic approaches to diabetes care invol
COMBINE 4 demonstrated that once-weekly IcoSema (icodec+semaglutide) offers superior glycemic control, weight reduction, and reduced hypoglycemia versus daily insulin glargine U100 in insulin-naive type 2 diabetes patients, supported by com
This review integrates recent randomized trial data with observational studies to clarify cannabis inhalation’s acute impact on cardiac ectopy, physical activity, sleep, and glucose, highlighting complex arrhythmia associations and cl
This study reveals a significant early onset of metabolic syndrome in men with prostate cancer treated with combined ADT and ARPI therapies, highlighting the necessity for multidisciplinary metabolic monitoring and interventions.
We report five pediatric MEN2B cases highlighting early extra-endocrine signs such as persistent constipation and alacrimia, enabling prompt genetic diagnosis and thyroidectomy before medullary thyroid carcinoma progression.
This study investigates how semaglutide exposure before and during pregnancy affects gestational weight gain and key pregnancy outcomes in women with overweight or obesity, highlighting increased risks that may stem from treatment discontin
A new sonographic pattern characterized by discontinuous peripheral punctate echogenic foci (DPEF) in thyroid nodules is strongly associated with papillary thyroid carcinoma (PTC), suggesting its potential as an important diagnostic marker
This study reveals a high heart failure risk within 5 years of diabetes diagnosis, highlighting insulin resistance and reduced kidney function as independent predictors beyond conventional risk factors.
A phase II basket trial demonstrates that vosoritide significantly increases growth velocity in children with RASopathies, ACAN, and NPR2 deficiencies, with an acceptable short-term safety profile, suggesting its potential as a precision th
This study reveals significant HbA1c and glucose discrepancies, especially in Black individuals, and introduces a personalized HbA1c correction (pA1C) that enhances diabetes management across racial groups.
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