OB/GYN & Women’s Health
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Vaginal Hysterectomy Versus Vaginal Assisted Natural Orifice Transluminal Endoscopic Surgery Hysterectomy: Results of a Randomized Controlled Trial
A randomized trial found vaginal assisted NOTES hysterectomy improved same-day discharge, operative time, and blood loss versus standard vaginal hysterectomy, without increasing complications or affecting recovery.
Trends and Characteristics of Inpatient versus Ambulatory Surgery for Endometriosis
A U.S. national study found endometriosis surgery is shifting from inpatient to outpatient care, with hospital cases more common in older, medically complex patients and those with more extensive disease.
Severe Surgical Complications During Cesarean Delivery Are Linked to Higher Postpartum Readmission Risk
Severe surgical complications during cesarean delivery were linked to about twice the risk of postpartum readmission within 42 days, especially for wound infection, supporting closer follow-up after complicated births.
Family History Misses Actionable Germline Variants in Many Ovarian Cancer Patients Over 70
A large real-world registry study shows that ovarian cancer patients aged 70 and older still carry clinically actionable germline variants, often without a reported family history, supporting broader age-inclusive genetic testing.
Menopausal Hot Flushes and Night Sweats May Be Linked to Retirement: What an Australian Study Found
A large Australian longitudinal study found that women with both hot flushes and night sweats had slightly higher odds of retirement, suggesting menopausal symptom burden may influence workforce participation.
Six Hours May Be Enough for Intrauterine Balloon Tamponade After Postpartum Hemorrhage
A randomized trial found that 6 hours of intrauterine balloon tamponade was noninferior to 18 hours for controlling postpartum hemorrhage after vaginal delivery, suggesting earlier removal may be reasonable in stable patients.
Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical Trial
A clinical trial found that weekly extended-release buprenorphine significantly improves illicit opioid abstinence during pregnancy compared to sublingual forms, with fewer serious adverse events, offering a safer treatment option for opioi
Estrogen Therapy Linked to Improved Survival in Certain Ovarian Cancer Patients Under 60
Study shows post-diagnosis estrogen therapy improves survival in high-grade serous and clear cell ovarian cancers but may worsen outcomes in endometrioid subtypes, offering guidance for managing menopausal symptoms in younger survivors.
Low-Dose Aspirin’s Pregnancy Benefit Appears Unchanged by Start Time or Adherence in a Large Multicentre Post Hoc Trial Analysis
In this post hoc analysis of a large randomized pregnancy trial, aspirin’s effects on preterm birth and perinatal mortality were not meaningfully modified by gestational age at initiation or measured adherence.
First-Trimester Maternal CMV Infection Concentrates the Risk of Fetal Brain Injury, Hearing Loss, and Autism Spectrum Disorder
A large prospective cohort suggests that long-term sequelae of congenital CMV after primary maternal infection are confined to first-trimester exposure, with autism spectrum disorder linked to temporal lobe white matter abnormalities.
Real-world Evidence: Managing Platelet Counts in Ovarian Cancer Patients on First-Line Maintenance Niraparib
A US cohort study of 543 ovarian cancer patients revealed 37% experienced decreased platelets during niraparib maintenance. Onset typically occurred within 1 month but resolved rapidly with dose adjustments, resulting in low discontinuation
Antenatal Prediction of Shoulder Dystocia and Birth Trauma Using Routine Maternal and Ultrasound Variables
A retrospective UK study of 24,334 pregnancies developed predictive models for shoulder dystocia and birth trauma using maternal characteristics and fetal abdominal circumference, showing improved accuracy over current methods.
Hematologic Response to Iron Therapy and Stillbirth Risk in Moderate Iron Deficiency Anemia
Study reveals inadequate hemoglobin improvement at 20-24 weeks after iron therapy increases stillbirth and preterm birth risks in moderate iron deficiency anemia pregnancies, highlighting need for early intervention.
HPV Self-Sampling May Expand Cervical Cancer Screening Access for Transmasculine and Nonbinary Patients
A narrative review suggests HPV self-sampling is acceptable and potentially practice-changing for transmasculine and nonbinary people who are often underscreened for cervical cancer.
Higher PFAS Exposure During Pregnancy Was Not Linked to Increased Gestational Diabetes in the ECHO Cohort
In a pooled U.S. pregnancy cohort, maternal PFAS concentrations were not associated with a higher prevalence of gestational diabetes, and fasting glucose findings were largely null.
Real-World Antibody-Drug Conjugate Outcomes in Gynecologic Cancers Appear Consistent Across Demographic Subgroups
In a single-center real-world cohort, survival with mirvetuximab soravtansine, trastuzumab deruxtecan, and tisotumab vedotin broadly mirrored pivotal trials, with no independent survival differences by age, race, or ethnicity after adjustme
Pregnancy Outcomes Among Individuals With Cerebral Palsy: A Population-Based Cohort Study
Canadian research reveals individuals with cerebral palsy face significantly higher risks of severe maternal complications, preterm birth, and neonatal issues during pregnancy, highlighting the need for specialized perinatal care.
Gut Microbiome Signatures May Help Explain Why Gestational Diabetes Raises Later Type 2 Diabetes Risk in Hispanic/Latina Women
In HCHS/SOL, prior gestational diabetes was linked to a proinflammatory gut microbiome, adverse metabolite patterns, and higher future type 2 diabetes risk, suggesting a plausible microbiome-mediated pathway after pregnancy.
Danish Multicenter Study Finds a 15% ADNEX Threshold Best Balances Early Detection and Referral Burden for Adnexal Masses
In a Danish multicenter cohort of adnexal masses, IOTA-based models outperformed RMI for routine triage. A 15% ADNEX threshold best balanced sensitivity and referral burden in non-tertiary care.
Early Pregnancy Oxylipin Biomarkers Linked to Fetal Growth Restriction Patterns
Study reveals specific inflammation and oxidative stress markers in early pregnancy urine predict distinct fetal growth restriction patterns, offering potential for early detection and intervention strategies.
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