Internal Medicine
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324 articles · 20 / page
Deciphering the Clinician’s Dilemma: Determinants of Antihypertensive Treatment Intensification in Older Adults
This review analyzes the complex factors influencing blood pressure management in older adults, highlighting how age, frailty, and digital health data shape clinician decisions and clinical inertia.
Nerandomilast Shows Potential Mortality Benefit in IPF Despite Neutral Composite Secondary Endpoints: Insights from FIBRONEER-IPF Extended Follow-up
Long-term data from the FIBRONEER-IPF trial indicates that while nerandomilast did not significantly impact composite respiratory events, the 18 mg dose suggests a numerical reduction in mortality and maintains a favorable safety profile fo
Every Hour Counts: Emergency Department Boarding Linked to Increased Clinical Deterioration and Mortality
A large-scale retrospective study involving over 170,000 patients demonstrates that prolonged emergency department boarding significantly increases the odds of early clinical deterioration and 28-day mortality, emphasizing the urgent need f
Beyond Shared Identity: How Physician-Patient Racial Concordance Modulates Inpatient Advance Care Planning
A large-scale study of 390,000 hospitalizations reveals that while racial concordance modestly increases advance care planning (ACP) discussions, physician race and systemic quality initiatives play significant, nuanced roles in end-of-life
Redefining Gout Management: Cardiovascular Risk Reduction via Treat-to-Target Urate-Lowering Therapy
Achieving serum urate targets
Reduced Intestinal Epithelial GPX4 Expression Predicts Postoperative Crohn’s Disease Recurrence and Offers a Novel Therapeutic Target
A breakthrough study identifies epithelial Glutathione peroxidase 4 (GPX4) deficiency as a potent predictor of Crohn’s disease recurrence after surgery. The research links this biomarker to endoplasmic reticulum stress and highlights seleni
Hormones and Aging, Not Just Diet: Unmasking the Sex-Specific Drivers of Plasma Ketone Levels
A large-scale analysis of the PREVEND cohort reveals that fasting β-hydroxybutyrate levels are primarily driven by sex-specific factors: oral contraceptives and menopause in women, and aging in men, challenging the dietary-centric view of k
Beyond Statins: The Evolution and Clinical Impact of PCSK9 Inhibition in Cardiovascular Risk Management
This article explores the transformation of lipid management through PCSK9 inhibitors. From genetic discovery to landmark cardiovascular outcomes trials, we examine how monoclonal antibodies, RNA interference, and gene editing are redefinin
Redefining Heart Valve Disease: The Battle Over Atrial Functional Mitral Regurgitation Guidelines
This article explores the critical differences between JACC and ESC definitions for Atrial Functional Mitral Regurgitation (AfMR), highlighting how the JACC Consensus provides a more robust prognostic framework for managing this emerging he
Impact of Polygenic Risk Scores on the Clinical Presentation and Glycaemic Variability of GCK-MODY
This article explores how polygenic background modifies GCK-MODY clinical phenotypes, influencing HbA1c levels and diagnostic thresholds. Findings highlight the distinct polygenic patterns in GCK-MODY compared to HNF1A-MODY, emphasizing the
Optimizing the ‘When’ of Exercise: Afternoon and Evening Activity as a Precision Medicine Tool for Diabetes Risk Reduction
New evidence from the UK Biobank and NHANES suggests that the timing of moderate-to-vigorous physical activity (MVPA) significantly impacts type 2 diabetes risk. Clustering activity in the afternoon and evening provides superior metabolic p
Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial
This phase 2 trial demonstrates that memantine, an NMDA receptor antagonist, significantly reduces premature atrial contractions (PACs) and nonsustained atrial tachycardia burden, suggesting the cardiac glutamatergic system as a novel thera
Accelerated 3-Year MD Graduates Match or Exceed Traditional Peers in Residency Performance: Evidence from ACGME Milestone 2.0
A comprehensive retrospective cohort study finds **Implementing Study Findings** I’m now integrating the Brenner et al. (2026) data into the “Key Findings” section. I’m focusing on providing a clear presentation of the ACGME Milestone 2.0 s
Post-Pandemic Firearm Acquisition and Household Exposure: Insights from the 2024 National Firearms Survey
The 2024 National Firearms Survey reveals that 29.8 million US adults acquired firearms between 2021 and 2024. This trend introduced 11.2 million new owners, significantly increasing household exposure for millions of adults and children, r
Holding GLP-1/GIP Agonists Before Upper Endoscopy Reduces Residual Gastric Volume Risk: Insights from the OCULUS Randomized Trial
The OCULUS randomized trial demonstrates that continuing GLP-1/GIP agonists before upper endoscopy significantly increases the risk of clinically significant residual gastric volume compared to holding a single dose, providing crucial evide
Breaking the Fasting Mandate: Is It Time to Re-evaluate Levothyroxine Administration?
A randomized clinical trial demonstrates that a 15% dose increase allows levothyroxine to be taken with breakfast without compromising TSH stability, significantly improving patient preference and well-being.
The Rising Tide of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Synthesis of Medication Eligibility and Clinical Implementation
This review synthesizes population-level data on the eligibility for GLP-1RAs, SGLT2is, and nsMRAs, highlighting that over 60% of US adults meet indications for these transformative therapies.
Coronary Artery Calcium Scoring Remains the Definitive Risk Stratifier for Patients With Elevated Lipoprotein(a)
A large multicohort study involving 11,319 participants confirms that Coronary Artery Calcium (CAC) scoring effectively stratifies cardiovascular risk even in individuals with high Lipoprotein(a), providing clinical clarity for personalized
CRLF1 Secreted by Cardiac Fibroblasts: A New Driver and Potential Therapeutic Target for Hypertrophic Cardiomyopathy
This article explores a groundbreaking study identifying CRLF1, a protein secreted by cardiac fibroblasts, as a key driver of Hypertrophic Cardiomyopathy (HCM). This paracrine signaling mechanism offers a potential universal therapeutic tar
Strengthening the Patient Voice: New Guidance for Qualitative Research in Internal Medicine
This article outlines new expert consensus on conducting rigorous qualitative research in internal medicine, providing a roadmap for investigators to move beyond numbers and capture the human experience of healthcare through methods like in
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