Internal Medicine
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Unveiling Frailty in England’s Homeless Population: Socioeconomic Insights and Health Implications
A large-scale analysis reveals high frailty prevalence among people experiencing homelessness in England, highlighting critical socioeconomic factors influencing vulnerability.
Integrating Exercise and Medication Management in Geriatric Care: A Holistic Approach to Improve Health Outcomes and Reduce Polypharmacy
Integrating exercise prescriptions with medication management offers a holistic strategy to optimize health, reduce polypharmacy, and mitigate adverse effects in older adults, enhancing their functional status and quality of life.
Revisiting Obesity Classification: Insights from a Population-Based Survey in Peru Using New Clinical Frameworks
This review examines a landmark Peruvian study applying new obesity definitions that incorporate clinical dysfunction and adiposity measures beyond BMI, revealing substantial underdiagnosis with traditional approaches and ethnic variation i
Comparative Risks of MASLD and MetALD: Insights from a Comprehensive Meta-Analysis on Hepatic and Extrahepatic Outcomes
This meta-analysis reveals that MetALD confers higher risks of liver-related events, hepatocellular carcinoma, and extrahepatic cancers compared to MASLD, while mortality and cardiovascular risks are similar, emphasizing tailored clinical a
Real-World Insights into HER2-Positive Metastatic Breast Cancer Treatments: Comparing T-DXd, T-DM1, and Tucatinib
This study uses real-world data to compare the effectiveness and safety of trastuzumab deruxtecan versus trastuzumab emtansine and tucatinib in HER2-positive metastatic breast cancer, confirming their clinical value.
Monlunabant Shows Promise for Weight Loss in Obesity and Metabolic Syndrome: A Phase 2A Trial Review
This phase 2a trial demonstrates that monlunabant induces significant weight loss across various doses in obese adults with metabolic syndrome, with dose-dependent adverse events highlighting the need for further safety evaluation.
Comparative Effectiveness of Long-Acting Injectable Versus Oral Antipsychotics in Older Adults with Schizophrenia: Insights from Hong Kong’s Population-Based Study
This study compares long-acting injectable to oral antipsychotics in older schizophrenia patients, highlighting benefits in relapse prevention and mortality reduction, with specific considerations for adverse effects.
Deciphering the Impact of Resistance Genes on Antibiotic Efficacy in E. coli: Insights from a Comprehensive Study
This study quantifies how specific resistance genes influence minimum inhibitory concentrations in E. coli, enhancing prediction accuracy for antibiotic resistance.
Navigating the AI Revolution in Health Care: Insights from the JAMA Summit
Artificial intelligence is reshaping health care, offering vast potential benefits alongside significant challenges. The JAMA Summit emphasizes the need for robust evaluation, equitable deployment, and multi-stakeholder collaboration to ens
Lithium’s Role in Reducing Suicidal Ideation and Behaviors: An Updated Meta-Analysis of Randomized Controlled Trials
This systematic review evaluates lithium’s efficacy in reducing suicidal ideation, attempts, and completed suicide, highlighting methodological challenges and the likelihood of benefit despite lack of statistical significance in RCTs.
Coenzyme Q10 in Depression and Anxiety: Evaluating Therapeutic Potential Through Meta-Analysis
This meta-analysis examines Coenzyme Q10 supplementation’s impact on depression and anxiety, revealing modest benefits for depression at low doses and short durations but insufficient evidence for anxiety improvement.
Quantifying Blood Pressure Reduction: Efficacy of Monotherapy and Combination Antihypertensives in Hypertension Management
This comprehensive meta-analysis quantifies the efficacy of five major antihypertensive drug classes and their combinations, providing clinicians with evidence-based guidance on blood pressure-lowering intensity to optimize hypertension tre
Enhancing Venous Thromboembolism Prevention Through Patient-Centered Nurse and Patient Education in Community Hospitals
A nurse-driven, patient-centered education bundle significantly reduced missed doses of venous thromboembolism prophylaxis in a community hospital, demonstrating scalable improvements in prophylaxis adherence beyond academic centers.
Simplifying Ulcerative Colitis Treatment: Evaluating a Single 1600 mg 5-ASA Tablet Regimen in the EASI Trial
The EASI trial compared a once-daily 1600 mg 5-ASA tablet with the conventional three 800 mg tablet regimen for ulcerative colitis, finding similar adherence and relapse rates, suggesting a feasible simpler alternative.
Persistent High Mortality in Severe Alcohol-Associated Hepatitis: Insights from a Five-Decade Meta-Analysis
This meta-analysis reveals that short-term mortality in severe alcohol-associated hepatitis remains high, with no significant improvement over the past four decades despite advances in care, underscoring the urgent need for better therapies
Obeticholic Acid Non-Response Signals Higher Clinical Risk in Primary Biliary Cholangitis
In primary biliary cholangitis (PBC) patients treated with obeticholic acid (OCA), biochemical non-response strongly predicts a higher risk of clinical events including liver decompensation and mortality, underscoring the need for improved
Gut Microbiota Dysbiosis in Cirrhotic Portal Hypertension: Unraveling Microbial Contributions to Disease Progression
Altered gut microbiota composition and metabolism exacerbate cirrhotic portal hypertension, highlighting potential microbiome-targeted therapies to mitigate disease progression.
Aspirin Use in Older Adults: Insights from the ASPREE-XT Study on Healthy Lifespan
Extended follow-up from the ASPREE-XT study shows low-dose aspirin does not improve healthy lifespan—defined as survival free of dementia, persistent disability, or death—in healthy older adults, and its risks include increased major hemorr
Guardians Within: The Nobel-Winning Discovery of Regulatory T Cells and Their Role in Immune Balance
The 2025 Nobel Prize in Physiology or Medicine honors groundbreaking work on regulatory T cells, revealing how the immune system avoids self-attack while combating threats, paving the way for novel therapies in autoimmune and transplant med
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