Internal Medicine
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How Much Aerobic Exercise Is Enough to Reduce Depression in Patients with Chronic Illness? A Dose–Response Meta-analysis Points to an Achievable Target
A meta-analysis of 36 RCTs (n=2,500) found aerobic exercise significantly reduces depressive symptoms in people with chronic illness (Hedges’ g -0.73). A weekly dose of ≈405 MET‑min (≈120–135 min of moderate aerobic activity) reaches a mini
Lean MASLD Is Not Benign: Higher Liver Events and Mortality in Normal-BMI Patients Across Three Large Cohorts
A pooled analysis of three population cohorts shows lean MASLD carries higher risks of liver-related events and all-cause and liver-related mortality despite lower cardiovascular event risk compared with non-lean MASLD.
Understanding Nonceliac Gluten/Wheat Sensitivity: A Global Perspective on a Common But Complex Condition
Nonceliac gluten/wheat sensitivity affects about 1 in 10 people worldwide, with strong links to female sex, psychological distress, and irritable bowel syndrome. This article explores its prevalence, symptoms, challenges in diagnosis, and i
Weekly Amylin Agonist Eloralintide Produces 10–21% Weight Loss at 48 Weeks in Phase 2 Trial
In a 48‑week multicenter phase 2 trial, weekly amylin receptor agonist eloralintide produced dose‑dependent mean weight loss of 9.4%–20.9% versus 0.4% for placebo, with improved waist circumference and cardiometabolic markers; tolerability
Indirect Calorimetry Reveals Hypermetabolism That Predicts Accelerated Muscle Loss and Energy Deficit Risk in ICU Patients
Serial indirect calorimetry–measured hypermetabolism is independently associated with more rapid CT-quantified muscle wasting and higher risk of energy deficit in critically ill adults, suggesting personalized metabolic monitoring could gui
Higher Vitamin B12 from Mid- to Late Life Is Associated with Slower Cognitive Decline: Evidence and Implications
Elevated vitamin B12 levels from mid- to late life correlate with reduced rates of cognitive decline across language, memory, and executive function domains, independent of folate status, highlighting potential preventative strategies again
How Eli Lilly and NVIDIA’s AI Supercomputer is Revolutionizing Drug Discovery
Eli Lilly and NVIDIA have partnered to launch the largest AI-powered supercomputing platform in pharma, aiming to accelerate drug discovery, personalize medicine, and enhance manufacturing through unprecedented computational power.
Navigating the Caffeine-Sleep Dilemma in Athletic Performance Enhancement
Caffeine boosts sports performance but may impair sleep quality, especially when consumed later in the day. Individualized strategies balancing caffeine intake and sleep hygiene can optimize athlete performance and recovery.
Red Blood Cell Metabolism Modulates Muscle Oxygenation and Limits Exercise Capacity: Insights from a Randomized Double‑Blind Crossover Study
A randomized crossover study in 20 men shows exercise‑induced oxidative stress alters erythrocyte redox and glycolytic metabolism, reduces 2,3‑BPG/ATP generation, and modestly impairs muscle oxygen extraction and arm exercise VO2peak, sugge
Urolithin A in Elite Distance Runners: Improves Recovery and Perceived Effort but Not Race Performance in 4-Week Altitude Training
A randomized, placebo-controlled trial in highly trained male distance runners found 4 weeks of 1000 mg/day urolithin A reduced markers of muscle damage and perceived exertion and upregulated mitochondrial proteomic pathways, but did not pr
Rethinking Prediabetes: Controlling Blood Sugar Without Losing Weight Shows Promise
A groundbreaking study reveals that lifestyle changes improving fat distribution and insulin function can reverse prediabetes without weight loss, significantly cutting type 2 diabetes risk.
Comparative Efficacy and Safety of Tirzepatide, Semaglutide, and Liraglutide for Obesity Management: A Critical Review of Recent Cochrane Evidence
This article critically compares the efficacy, safety, and long-term outcomes of tirzepatide, semaglutide, and liraglutide for the treatment of obesity based on recent Cochrane systematic reviews, highlighting differences in weight loss, ad
Physical Therapy for Degenerative Meniscal Tear: No Added Benefit Over Home Exercise Alone in Knee Pain Management
A randomized trial shows that physical therapy and text message reminders do not significantly improve knee pain outcomes beyond a simple home exercise program in patients aged 45-85 with degenerative meniscal tears.
Unraveling Genetic Links Between Problematic Alcohol Use and Psychiatric Disorders: Insights from Large-Scale Genomic Analyses
This study reveals significant shared genetic architectures between problematic alcohol use and various psychiatric disorders, identifying key genes like TTC12 and ANKK1 that may underlie their comorbidity.
Handgrip Strength as a Predictor of Preclinical Obesity Progression and Mortality: Insights from the UK Biobank Multistate Model Analysis
This study reveals that higher handgrip strength is significantly associated with reduced risks of preclinical obesity progression and mortality, highlighting the importance of muscle strength in managing early obesity-related health risks.
Survival Benefits of Deceased Donor Kidney Transplant versus Waitlisting: Insights from a Population-Based Cohort Study
Deceased donor kidney transplantation improves survival compared to dialysis waitlisting, with benefits varying by donor kidney quality and recipient age. Low-risk kidneys yield the greatest survival gains, particularly in older recipients.
Venomous Snakes and Snakebites in the US: What You Need to Know to Stay Safe
Venomous snakes cause thousands of bites annually in the US, with serious health consequences. Understanding snake types, symptoms, first aid, and prevention can save lives.
Rivaroxaban in Cirrhosis: A Promising Strategy to Prevent Portal Hypertension Complications
The CIRROXABAN trial evaluates rivaroxaban’s efficacy and safety in preventing complications of portal hypertension in cirrhotic patients, suggesting improved complication-free survival without significantly increasing major bleeding risk.
Rivaroxaban in Cirrhosis: A Promising Strategy to Prevent Portal Hypertension Complications
The CIRROXABAN trial evaluates rivaroxaban’s efficacy and safety in preventing complications of portal hypertension in cirrhotic patients, suggesting improved complication-free survival without significantly increasing major bleeding risk.
Unraveling Non-Acute Decompensation in Cirrhosis: A Distinct Clinical and Pathophysiological Entity with Prognostic Implications
Non-acute decompensation of cirrhosis (NAD) represents a distinct clinical state characterized by elevated cell death markers and moderate prognosis. Identifying predictors such as ascites severity and biomarkers Gasdermin-D and RIPK3 may g
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