Infectious Diseases
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Efficacy and Safety of High-Dose Versus Low-Dose Primaquine for Plasmodium vivax in Cambodia: A Randomised Controlled Trial
A Cambodian study shows that a 14-day high-dose primaquine regimen (7.0 mg/kg) significantly reduces Plasmodium vivax relapse compared to the standard low-dose (3.5 mg/kg), with comparable safety in G6PD-normal patients.
Corynebacterium diphtheriae Outbreak among Migrants in Europe: Clinical, Epidemiologic, and Microbiologic Insights
A multicountry outbreak of diphtheria among migrants in Europe raised concerns about cutaneous and respiratory disease, cross-border spread, and emerging antibiotic resistance. Genomic analysis revealed multiclonal transmission and resistan
Mass Ivermectin Administration for Malaria Control: Translational Insights from Recent Cluster-Randomized Trials
Recent cluster-randomized trials in Kenya and Burkina Faso provide mixed but informative evidence on the efficacy and safety of mass ivermectin administration for malaria control, highlighting both its potential and limitations.
Fecal Microbiota Transplantation versus Vancomycin in Primary Clostridioides difficile Infection: A Noninferiority Randomized Trial
FMT is noninferior to vancomycin for primary CDI, with similar cure rates and safety, suggesting it may be a viable first-line therapy.
West Nile Virus: Clinical Burden, Diagnostic Challenges, and Prevention in the U.S.
West Nile virus is the leading mosquito-borne disease in the U.S., causing significant neuroinvasive morbidity and mortality, especially in older and immunocompromised individuals. With no approved treatments or vaccines, prevention and sur
Dual IL-17A/F Blockade and Increased Candidiasis Risk
Blocking both IL-17A and IL-17F impairs neutrophil migration, reducing antifungal defense and raising candidiasis risk in patients on bimekizumab, according to in vitro evidence.
Is There a Norovirus Vaccine on the Horizon? Scientific Progress, Challenges, and Future Directions
Norovirus vaccines show promise in clinical trials, but scientific and logistical challenges remain. No approved vaccine exists yet, though novel approaches, including oral pills, are advancing development.
Influenza-Associated Acute Necrotizing Encephalopathy in US Children
A multicenter US study highlights the devastating burden of influenza-associated acute necrotizing encephalopathy in children, with high mortality and disability rates despite aggressive therapy, underscoring the urgent need for prevention
Rising Threat: Triazole-Resistant Aspergillus fumigatus and the Challenge of Fungal Antimicrobial Resistance
A 29-year genomic study reveals increasing genetic diversity and prevalence of triazole-resistant Aspergillus fumigatus, raising concerns for clinical management and highlighting the need for novel diagnostics and antifungal strategies.
Low Hepatitis C Treatment Rates in Children: Understanding the Barriers and Opportunities
A study published in Pediatrics reveals low rates of hepatitis C treatment among children, highlighting significant racial disparities and access challenges.
Why Do New Infectious Diseases Keep Emerging? Understanding the Comeback and Evolution of Pathogens
New infectious diseases continue to emerge and old ones resurge due to evolving pathogens, environmental changes, and global interconnectedness. Understanding these dynamics is key to prevention and response.
Are We Winning or Losing the Battle Against Viruses and Microbes?
A deep dive into humanity’s ongoing struggle with viruses and microbes—what science reveals, common myths, and how we can best protect ourselves.
Antibiotic Use Before Age Two May Increase Allergy Risk, Study Finds
Research presented at the European Respiratory Society’s annual meeting links early antibiotic use in children to increased allergy risks such as eczema and hay fever.
The Invisible Enemy: Are Superbugs Winning the War on Antibiotics?
Antibiotic resistance is growing worldwide, threatening our ability to treat common infections. Discover the science, misconceptions, and what we can all do to combat superbugs.
Impact of Obesity on Long COVID: Insights from Primate Studies
Obesity influences the long-term effects of SARS-CoV-2, revealing diverse outcomes in primates and suggesting broader implications for humans.
“Urgent Alert: Fatal Brain Infection Linked to Nasal Irrigation in Elderly Woman”
Title: When Routine Health Practices Turn Risky: A Closer Look at Nasal Irrigation and Primary...
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