Gastroenterology
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Flaxseed Powder Supplementation: Emerging Evidence in Non-Alcoholic Fatty Liver Disease and Metabolic Health
Flaxseed powder supplementation shows promise in improving liver fat, lipid metabolism, and inflammation in NAFLD and related metabolic disorders, with effects on gut microbiota but limited synergism with fasting mimicking diets.
The Effect of Chitosan Supplementation on Liver Function, Hepatic Steatosis Predictors, and Metabolic Indicators in Adults with Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
This clinical trial evaluates chitosan supplementation’s impact on liver health and metabolic markers in adults with NAFLD, showing potential benefits alongside a low-calorie diet.
Empowering Community Liver Health: Insights from the LOCATE-NAFLD Trial on Nurse-Led MASLD Screening
The LOCATE-NAFLD trial demonstrates that nurse-delivered, community-based liver screening is highly acceptable and effective for identifying high-risk MASLD patients, but faces challenges in sustainable adoption.
Mediterranean Diet Combined with Early Time-Restricted Feeding: A Promising Strategy for MASLD – Insights from the CHRONO-NAFLD Trial
A 12-week hypocaloric Mediterranean diet with early time-restricted feeding improved glycaemic control and cardiometabolic risk in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) compared to unrestricted timin
One Year of Gluten-Free Diet Impacts Gut Function and Microbiome in Celiac Disease
A study reveals that one year of a gluten-free diet partially improves gut function and microbiome composition in celiac disease but does not fully restore them to normal levels.
Understanding Liver Cysts: Are They Dangerous?
Explore liver cysts, their causes, symptoms, risks, treatment, and prevention strategies to demystify this common condition.
Maintaining Hunger Sensation to Delay Aging
Research indicates that the sensation of hunger triggered by calorie restriction can influence gene expression, helping to delay aging and extend lifespan by up to 35%.
Explainable Artificial Intelligence for Predicting Refractory Ulcerative Colitis: Insights from a Japanese Nationwide Registry
A machine learning model using nationwide registry data accurately predicts long-term remission in refractory ulcerative colitis and identifies key prognostic factors such as pseudopolyps.
Consecutive Fecal Microbiota Transplantation in MASLD: Insights from a Double-Blind Randomized Controlled Trial
A double-blind RCT found that three consecutive fecal microbiota transplantations did not significantly improve hepatic steatosis or metabolic parameters in patients with MASLD, suggesting patient selection based on microbiota diversity may
Low-Dose Hydrocortisone in Cirrhotic Patients With Septic Shock: A Double-Blind Randomised Placebo-Controlled Trial
This trial evaluated low-dose hydrocortisone in cirrhotic patients with septic shock, finding no improvement in 28-day mortality or shock resolution compared to placebo.
Waist Size Proves Key to Assessing Liver Health
Waist circumference is a superior predictor of metabolic liver diseases, outperforming BMI and other body metrics in assessing MASLD, MASH, and liver stiffness risks.
Perinatal Antibiotic Exposure Alters Neonatal Gut Microbiota in Preterm Infants: Clinical Implications for Infection Risk and Microbial Maturation
Perinatal antibiotic exposure in preterm infants disrupts gut microbiota composition, increasing pathogenic bacteria and reducing beneficial species, with implications for infection risk and the protective role of breastfeeding.
Probiotics and Prebiotics: Unlocking the Secrets of Gut Health and Immunity
Explore how probiotics and prebiotics fortify gut health, boosting immune response and overall well-being.
Your Gut, Your Mood: How the ‘Second Brain’ Can Beat the Blues
Explore how the gut, often called the ‘second brain,’ influences mood and mental health, and learn ways to nurture this connection for better emotional well-being.
Two Types of Intestinal Polyps with High Risk of Developing into Colorectal Cancer: Four Signs During Bowel Movements Indicating Polyps
Intestinal polyps are mucosal growths that can lead to colorectal cancer. Two types, adenomatous and familial adenomatous polyps, carry a high cancer risk. Early removal and lifestyle adjustments are key to prevention.
Recognizing Abnormal Bowel Movements: Could Intestinal Polyps Be the Cause?
Intestinal polyps are often benign but can become cancerous. This article explores symptoms, risk factors, and colonoscopy guidelines to help identify and prevent colorectal cancer.
Guselkumab for Crohn’s Disease and Ulcerative Colitis: Efficacy and Safety from Recent Phase 3 Trials
Phase 3 studies demonstrate guselkumab’s efficacy and safety as induction and maintenance therapy for moderate-to-severe Crohn’s disease and ulcerative colitis, with superiority over placebo and favorable safety profiles.
Distinct Genomic Mutation Patterns in Early-Onset Colorectal Cancer: Implications for Clinical Stratification and Precision Medicine
A large international study reveals unique somatic mutation profiles and higher mutational burden in hypermutated early-onset colorectal cancer, highlighting the need for age-specific molecular diagnostics and management strategies.
Pre-emptive TIPS vs Glue Obliteration for Acute Fundal Variceal Bleeding in Cirrhosis: Key Insights from the GAVAPROSEC Trial
The GAVAPROSEC trial demonstrates that pre-emptive TIPS significantly reduces 1-year mortality and rebleeding in cirrhotic patients with acute fundal gastric variceal bleeding compared to glue obliteration plus NSBB.
EASE-CD: A Validated Endoscopic Ulcer Activity Score for Crohn’s Disease—Clinical Utility and Evidence from Randomized Trials
The EASE-CD index offers a reliable, validated, and responsive tool for quantifying Crohn’s disease ulcer activity in clinical trials and practice, improving upon prior endoscopic indices.
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