Gastroenterology
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Efimosfermin Alfa (BOS-580) in Metabolic Dysfunction-Associated Steatohepatitis: Promising Phase 2a Results
Efimosfermin alfa, a long-acting FGF21 analogue, demonstrated a favorable safety profile and significant reductions in hepatic fat in patients with metabolic dysfunction-associated steatohepatitis (MASH) in a phase 2a randomized controlled
Targeting TL1A in IBD: Safety and Efficacy of Tulisokibart in Crohn’s Disease and Ulcerative Colitis—Emerging Phase 2 Data
Phase 2 trials show anti-TL1A antibody tulisokibart offers potential efficacy and good tolerability in refractory Crohn’s disease and ulcerative colitis, with ongoing phase 3 studies to confirm findings.
Interval Colorectal Cancer Risk and Outcomes after Positive FIT with Follow-Up Colonoscopy in Taiwan Screening Program
A Taiwanese cohort study reveals higher interval colorectal cancer incidence and mortality after follow-up colonoscopy for positive FIT compared to negative FIT, highlighting risk stratification and adenoma detection rate impact on outcomes
Efruxifermin for Compensated Liver Cirrhosis in MASH: Phase 2b Results and Clinical Implications
A phase 2b trial found that efruxifermin did not significantly improve fibrosis at 36 weeks in patients with compensated cirrhosis due to MASH, though longer-term benefit was suggested at 96 weeks.
Multidose Ondansetron After Emergency Visits: Reducing Gastroenteritis Severity in Children
A randomized trial shows that multidose ondansetron after pediatric ED visits for gastroenteritis reduces moderate-to-severe illness, though impact on vomiting duration and healthcare utilization is limited.
Two-Step Clinical Pathway for MASLD: Precision Risk Stratification of Hepatic Events Validated in a Multinational Prospective Cohort
A large, multinational cohort study demonstrates that a two-step algorithm—combining FIB-4 with VCTE—precisely stratifies MASLD patients by liver-related event risk, optimizing resource use and guiding clinical management.
Sharp Rise in Advanced Alcohol-Related Liver Disease Despite Stable Drinking Rates: Changing Population Risks Highlighted by US Data
A twofold rise in advanced liver fibrosis among US heavy drinkers over two decades is linked to increased metabolic syndrome, age, and socioeconomic risk, not higher alcohol intake.
GLP-1 Receptor Agonists and Risk of GERD in Type 2 Diabetes: Clinical Implications from a Large Population-Based Cohort Study
GLP-1 receptor agonists modestly increase the risk of GERD and its complications compared to SGLT-2 inhibitors in type 2 diabetes patients, highlighting the need for vigilant symptom monitoring.
Unraveling the Drivers of Pruritus Severity in Intrahepatic Cholestasis of Pregnancy: Insights from a Longitudinal Cohort Study
Peak bile acid levels and higher maternal BMI independently predict pruritus worsening in intrahepatic cholestasis of pregnancy, emphasizing the need for tailored monitoring and management as gestation advances.
Is There a Norovirus Vaccine on the Horizon? Scientific Progress, Challenges, and Future Directions
Norovirus vaccines show promise in clinical trials, but scientific and logistical challenges remain. No approved vaccine exists yet, though novel approaches, including oral pills, are advancing development.
Top U.S. Hospitals for Gastroenterology and GI Surgery: 2025-2026 Rankings and Clinical Implications
Mayo Clinic leads U.S. News’ 2025-2026 rankings for gastroenterology and GI surgery, reflecting excellence in outcomes, capabilities, and research. This review examines the clinical context, ranking methodology, and relevance for clinicians
Elevated Colorectal Cancer Risk in Patients with IBD and Primary Sclerosing Cholangitis: Insights from a National Swedish Cohort
Patients with inflammatory bowel disease (IBD), particularly those with primary sclerosing cholangitis (PSC) or early-onset disease, face a substantially increased risk of colorectal cancer (CRC), emphasizing the need for vigilant surveilla
Gallstones: Causes, Symptoms, and Treatment Options
Learn about gallstones, their causes, symptoms, and whether gallbladder removal is necessary. Explore preventive tips for maintaining gallbladder health.
Why Is Diarrhea More Common in Summer? Science, Myths, and Smart Prevention
Explore why diarrhea rates spike in summer, the science behind it, common misconceptions, and practical ways to stay healthy during the hottest months.
Why Do Children Often Get Diarrhea After Taking Antibiotics?
Explore the scientific reasons behind antibiotic-associated diarrhea in children, common misconceptions, and practical advice for parents and clinicians.
Gut Feeling: The Surprising Link Between Your Stomach and Your Mood
Emerging science reveals how your gut and brain communicate, shaping not only digestion but also emotions and mental health.
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