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Smartphone photoplethysmography before planned cardioversion reduced same-day cancellations in patients with atrial fibrillation or flutter by detecting spontaneous return to sinus rhythm early.
A Circulation study identifies MAML1 as a candidate congenital heart disease gene and shows that defective phase separation in endocardial cells suppresses Notch signaling, impairing endocardial-to-mesenchymal transition and causing septal
A large-scale Dutch cohort study reveals that women with a history of spontaneous preterm birth face a significantly elevated risk of cardiovascular mortality, with the highest risk observed in those delivering before 32 weeks of gestation.
A validated model, SABRE, estimates who with type 2 diabetes may gain the most heart-failure prevention benefit from SGLT2 inhibitors, enabling more precise, individualized prescribing.
In a post hoc analysis of CLEAR Outcomes, bempedoic acid was associated with a significantly lower risk of venous thromboembolism, including deep vein thrombosis and pulmonary embolism, among statin-intolerant patients at high cardiovascula
Thyroid dysfunction reshapes lipid metabolism, vascular tone, cardiac performance, and rhythm. Cardiovascular risk is clearest at the extremes of thyroid status, while treatment decisions in subclinical disease should remain individualized.
Continuous ICM monitoring in heart failure found a high burden of atrial fibrillation, bradyarrhythmia, and VT/VF. Arrhythmias were linked to more interventions and higher hospitalization risk, but the congestion-management strategy did not
Recent high-quality randomized clinical trials and meta-analyses suggest that routine magnesium sulfate infusion does not effectively prevent postoperative atrial fibrillation in cardiac surgery, especially when used alongside standard beta
In selected children with out-of-hospital cardiac arrest, extracorporeal CPR was associated with higher one-month survival and better neurologic outcomes than continued conventional CPR, though the study was observational and estimates were
In a GUIDE-HF analysis using CardioMEMS, new ARNI and MRA initiation was associated with modest short-term reductions in diastolic pulmonary artery pressure, whereas SGLT2 inhibitor initiation showed no detectable pressure change and β-bloc
A pooled US cohort analysis found that natural menopause before age 40 was associated with about a 40% higher lifetime risk of coronary heart disease in both Black and White women, supporting its use as a routine cardiovascular risk-enhanci
In a 12-hospital Dutch registry, surgical myectomy effectively relieved LVOT obstruction, but 30-day complications were more frequent in low-volume centers, in women, and when at least two concomitant procedures were performed.
A pooled analysis of 59,396 participants found that higher serum IL-6 concentrations independently predicted nine cardiovascular and mortality outcomes, with consistent associations across key clinical subgroups.
A large multi-cohort genome-first study found similar prevalence of pathogenic FH variants across ancestries, but more VUSs and greater LDL-C and myocardial infarction risk among African ancestry individuals, highlighting likely underclassi
A MINT trial subanalysis found no evidence that ICU status changes the relative effect of restrictive versus liberal transfusion in acute myocardial infarction with anemia.
Across four national cohorts, younger adults with type 2 diabetes had higher adiposity and triglycerides, while glycemia peaked in midlife and blood pressure and albuminuria rose with age, suggesting age-specific pathways to diabetes compli
In OPINION, prophylactic left atrial appendage occlusion during valve surgery did not significantly lower stroke, TIA, or cardiovascular death at 1 year in patients without pre-operative atrial fibrillation.
In ALLEVIATE-HF, ICM-based high-risk detection linked to centralized nurse-managed diuretic intervention was safe, but did not significantly improve the hierarchical composite outcome versus observation.
A prospective multicenter study found circulating microRNA rejection scores identified ACR and AMR with strong diagnostic performance and prognostic value, supporting their development as noninvasive tools to reduce reliance on surveillance
Oral semaglutide improved multiple cardiovascular risk factors in high-risk type 2 diabetes, including HbA1c, weight, systolic blood pressure, inflammation, and some lipid measures, with benefits sustained over nearly four years.
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