500 articles · 20 / page
The DARE-AF trial demonstrates that 10 mg of dapagliflozin for three months does not significantly reduce early arrhythmia recurrence or AF burden following catheter ablation in patients without existing indications for SGLT2 inhibitors.
Recent evidence identifies S-nitrosylation of Pyruvate Kinase M2 (PKM2) as a specific driver of cardiac fibrosis, suggesting that activating PKM2 with drugs like mitapivat could provide a long-sought therapeutic approach for heart failure p
The REVEAL-HCM study demonstrates that while mitral regurgitation is a frequent comorbidity in hypertrophic cardiomyopathy, its prognostic impact is highly subtype-specific, significantly affecting outcomes in non-obstructive subtypes but s
A 10-year multicenter study highlights that cardiac structural complications (CSCs) affect 2.1% of TAVR recipients. With a 35% 30-day mortality rate and no decline in incidence over a decade, these events remain a formidable challenge for i
Obesity-induced insulin resistance hinders heart failure recovery post-LVAD by disrupting the pentose phosphate pathway. A new study in Circulation suggests insulin sensitizers could restore cardiac repair mechanisms in obese patients.
A landmark multicenter study of 156 patients reveals that acute eosinophilic myocarditis frequently presents without peripheral eosinophilia, carries a high risk of death or heart transplant, and requires early immunosuppressive therapy to
Recent research reveals that the common ALDH2 rs671 genetic variant significantly enhances platelet activation and arterial thrombosis through aldehyde accumulation, reactive oxygen species, and ACAD10-mediated mitophagy, identifying ALDH2
This review synthesizes the landmark 2026 findings by Thériault et al., identifying 36 genomic loci and a significant polygenic contribution to bicuspid aortic valve, offering new insights into cardiac morphogenesis and clinical risk predic
A multicenter study of 680 Fabry disease patients reveals that age, renal function, QRS duration, and left ventricular mass are critical independent predictors of major adverse cardiovascular events, highlighting persistent unmet needs desp
Patients with myocardial infarction due to isolated coronary artery ectasia face a significantly higher risk of recurrent MI and stent thrombosis compared to those without ectasia, highlighting the need for specialized long-term management.
A retrospective study reveals that patients with myocardial infarction caused by isolated coronary artery ectasia face significantly higher risks of recurrence and stent thrombosis compared to those without ectasia, highlighting a critical
The STABLED randomized clinical trial found that adding catheter ablation to standard edoxaban therapy did not significantly reduce the risk of recurrent stroke or composite cardiovascular outcomes in patients with atrial fibrillation and a
Three-year pooled data from the ALTERRA trials demonstrate that the Alterra Adaptive Prestent combined with the SAPIEN 3 THV is highly effective and safe for treating severe pulmonary regurgitation in patients with large right ventricular o
This review analyzes new registry data revealing that low discharge gradients (<10 mm Hg) after balloon-expandable ViV-TAVR correlate with reduced LVEF and higher 5-year mortality, challenging conventional hemodynamic success metrics.
This review synthesizes findings on how APOL1 risk variants (G2) drive hypertension and kidney damage through cell-specific mechanisms involving STING activation and endothelin-1 production, offering new precision medicine pathways for high
A large-scale retrospective study challenges the classic view of cardiac amyloidosis, revealing that while restriction is the dominant phenotype at diagnosis, nearly one-third of patients present with preserved function, and progression pat
Researchers have discovered that the protein PRMT9 plays a vital role in healing the heart after a myocardial infarction by controlling inflammatory macrophages. By promoting the degradation of the STAT1 protein, PRMT9 reduces tissue damage
A large-scale study reveals that 25% of patients with SCAI Stage B cardiogenic shock deteriorate clinically. Acute kidney injury and diuretic resistance are identified as critical, independent predictors of poor outcomes, emphasizing the ne
A multicenter IVUS study demonstrates that rotational atherectomy significantly reduces target lesion revascularization in coronary calcified nodules. Crucially, this benefit is highly dependent on the presence of contralateral calcificatio
This review synthesizes findings from a 21- **Compiling final edits** Now that I’ve structured the article, I’m focusing on the final touches, particularly the content for the “Highlights,” “Expert Commentary,&
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