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Electronic Patient-Reported Outcome Monitoring With Alert-Based Interventions in Metastatic Breast Cancer: A Review of Evidence and Clinical Implications
Clinical Updatesdigital healthpatient-reported outcomes

Electronic Patient-Reported Outcome Monitoring With Alert-Based Interventions in Metastatic Breast Cancer: A Review of Evidence and Clinical Implications

By MedXY|Aug 7, 2026

This review synthesizes clinical trial evidence supporting digital patient-reported outcome monitoring with alert-based interventions to reduce fatigue and improve physical functioning in metastatic breast cancer.

Enfortumab Vedotin-Induced Cutaneous Toxicity: A Marker of Improved Survival in Advanced Urothelial Carcinoma
DermatologysurvivalAntibody-drug conjugate

Enfortumab Vedotin-Induced Cutaneous Toxicity: A Marker of Improved Survival in Advanced Urothelial Carcinoma

By MedXY|Aug 7, 2026

Enfortumab vedotin (EV) therapy in advanced urothelial carcinoma is frequently associated with cutaneous adverse events (cAEs). These EV-induced skin toxicities correlate independently with improved progression-free and overall survival, ev

Advancing Breast Flap Viability Assessment: Laser Speckle Contrast Imaging Versus Indocyanine Green Fluorescence
newsIndocyanine GreenBreast Reconstruction

Advancing Breast Flap Viability Assessment: Laser Speckle Contrast Imaging Versus Indocyanine Green Fluorescence

By MedXY|Aug 7, 2026

This article reviews a prospective study comparing Laser Speckle Contrast Imaging (LSCI) and Indocyanine Green (ICG) fluorescence for predicting necrosis in immediate breast reconstruction, highlighting LSCI’s repeatability and sensitivity

Resection Margin Status in Distal Cholangiocarcinoma: Implications for Recurrence and Adjuvant Radiotherapy Selection
General SurgeryrecurrenceAdjuvant radiotherapy

Resection Margin Status in Distal Cholangiocarcinoma: Implications for Recurrence and Adjuvant Radiotherapy Selection

By MedXY|Aug 6, 2026

This study elucidates the prognostic importance of bile duct resection margin status in distal cholangiocarcinoma, revealing that margin involvement significantly affects recurrence risk in node-negative patients and identifies potential ca

Preoperative Weight Loss in Obese Women With Atypical Hyperplasia or Low-Grade Endometrial Cancer: Feasibility and Outcomes
newsobesityEndometrial Carcinoma

Preoperative Weight Loss in Obese Women With Atypical Hyperplasia or Low-Grade Endometrial Cancer: Feasibility and Outcomes

By MedXY|Aug 18, 2026

A medically supervised preoperative weight loss program is feasible and leads to significant short-term weight reductions in women with obesity and atypical hyperplasia or low-grade endometrial carcinoma. Further research is necessary to co

Influence of Breast Reconstruction Type and Placement on Radiation Therapy Outcomes: Clinical Insights and Implications
newsBreast Reconstructioninternal mammary node

Influence of Breast Reconstruction Type and Placement on Radiation Therapy Outcomes: Clinical Insights and Implications

By MedXY|Aug 5, 2026

This study explores how breast reconstruction type and device placement impact radiation therapy planning, dose distribution, treatment timing, and complications, revealing nuanced effects on heart, lung doses, and internal mammary node cov

Revolutionizing Classical Hodgkin Lymphoma Treatment: The Promise of Anti-PD-1 Therapy
Hematology-OncologyNivolumabimmunotherapy

Revolutionizing Classical Hodgkin Lymphoma Treatment: The Promise of Anti-PD-1 Therapy

By MedXY|Aug 5, 2026

Anti-PD-1 therapy has transformed classical Hodgkin lymphoma management, demonstrating safety, feasibility, and durable efficacy across treatment settings—from relapsed/refractory disease to frontline therapy.

Breast Implant-Associated Anaplastic Large Cell Lymphoma: Insights into Cellular Diversity, Immune Suppression, and Therapeutic Opportunities
Hematology-Oncologyimmune suppressionTumor Microenvironment

Breast Implant-Associated Anaplastic Large Cell Lymphoma: Insights into Cellular Diversity, Immune Suppression, and Therapeutic Opportunities

By MedXY|Aug 5, 2026

BIA-ALCL is a heterogeneous T cell lymphoma marked by immunosuppressive tumor microenvironments that promote tumor survival and proliferation, revealing potential targets for advanced disease therapy.

One-Year Tumor Volume Regression as a Predictor of Survival in I-125 Plaque Brachytherapy for Posterior Uveal Melanoma
newssurvival predictiontumor volume regression

One-Year Tumor Volume Regression as a Predictor of Survival in I-125 Plaque Brachytherapy for Posterior Uveal Melanoma

By MedXY|Aug 4, 2026

Tumor volume regression at one year post-I-125 plaque brachytherapy significantly predicts overall survival in posterior uveal melanoma, with intermediate regression showing the best outcomes.

Enhanced Gynecologic Oncology Decision Support: Impact of Guideline-Anchored Retrieval-Augmented Generation Versus Baseline and Literature-Based AI Models
newsGynecologic Oncologylarge language models

Enhanced Gynecologic Oncology Decision Support: Impact of Guideline-Anchored Retrieval-Augmented Generation Versus Baseline and Literature-Based AI Models

By MedXY|Aug 18, 2026

A study benchmarking large language models in gynecologic oncology demonstrates that guideline-anchored retrieval-augmented generation (RAG) configurations outperform baseline and literature-only AI systems in clinical decision support, hig

Prognostic Stratification and Outcomes in Brain Metastases from Nonanaplastic Follicular Cell-Derived Thyroid Carcinoma: Insights from a Multicenter Retrospective Study
NeurologyPrognostic assessmentThyroid carcinoma

Prognostic Stratification and Outcomes in Brain Metastases from Nonanaplastic Follicular Cell-Derived Thyroid Carcinoma: Insights from a Multicenter Retrospective Study

By MedXY|Aug 4, 2026

This study identifies key prognostic factors and proposes a graded prognostic assessment to stratify survival in patients with brain metastases from nonanaplastic follicular cell-derived thyroid carcinoma.

Dual Immune Checkpoint Inhibition with Cemiplimab and Fianlimab Enhances Neoadjuvant Chemotherapy Response in Early-Stage High-Risk ERBB2-Negative Breast Cancer: Insights from the I-SPY2 Trial
newsneoadjuvant chemotherapyImmune Checkpoint Inhibition

Dual Immune Checkpoint Inhibition with Cemiplimab and Fianlimab Enhances Neoadjuvant Chemotherapy Response in Early-Stage High-Risk ERBB2-Negative Breast Cancer: Insights from the I-SPY2 Trial

By MedXY|Aug 18, 2026

The I-SPY2 trial shows that combining PD-1 and LAG-3 inhibitors with neoadjuvant chemotherapy significantly improves pathologic complete response rates in early-stage high-risk ERBB2-negative breast cancer, especially in patients with a pos

Cytogenetic Insights into Multiple Myeloma Outcomes Despite MRD Negativity Post-Autologous Stem Cell Transplant
Hematology-Oncologyautologous stem-cell transplantationHigh-Risk Cytogenetics

Cytogenetic Insights into Multiple Myeloma Outcomes Despite MRD Negativity Post-Autologous Stem Cell Transplant

By MedXY|Aug 2, 2026

This study reveals that certain high-risk cytogenetic abnormalities continue to influence progression-free survival in multiple myeloma patients even after achieving deep MRD negativity post-ASCT, highlighting the need for tailored post-tra

Patient Perceptions of Telehealth Use in Head and Neck Cancer Surveillance: A Qualitative Synthesis
Clinical Updatescancer surveillancehead and neck cancer

Patient Perceptions of Telehealth Use in Head and Neck Cancer Surveillance: A Qualitative Synthesis

By MedXY|Aug 2, 2026

This review synthesizes evidence on patients’ perceptions of telehealth for head and neck cancer surveillance, highlighting barriers, benefits, and the potential of hybrid models to improve acceptability post-treatment.

Maximizing Outcomes in Locally Advanced Pancreatic Cancer with Hypofractionated Ablative Radiation Therapy
General SurgeryAblative Radiation TherapyLocally Advanced Pancreatic Cancer

Maximizing Outcomes in Locally Advanced Pancreatic Cancer with Hypofractionated Ablative Radiation Therapy

By MedXY|Aug 2, 2026

Hypofractionated ablative radiation therapy after induction chemotherapy shows promise in patients with locally advanced pancreatic cancer, improving resectability and 2-year survival while maintaining acceptable safety profiles.

MLH1 Promoter Hypermethylation Does Not Impact Survival Outcomes in dMMR Endometrial Cancer Treated with Immune Checkpoint Inhibitors
newsimmune checkpoint inhibitorssurvival outcomes

MLH1 Promoter Hypermethylation Does Not Impact Survival Outcomes in dMMR Endometrial Cancer Treated with Immune Checkpoint Inhibitors

By MedXY|Aug 18, 2026

This study analyzes real-world data showing that MLH1 promoter hypermethylation and Lynch syndrome-associated genetic mutations confer similar response rates and survival outcomes in mismatch repair deficient endometrial cancer treated with

RIPPLY1 as a Guardian Against Cancer Stemness in CTNNB1-Mutated Hepatocellular Carcinoma
GastroenterologyCancer StemnessCTNNB1 mutation

RIPPLY1 as a Guardian Against Cancer Stemness in CTNNB1-Mutated Hepatocellular Carcinoma

By MedXY|Jul 31, 2026

RIPPLY1 suppresses cancer stemness by targeting TBX19, improving prognosis in CTNNB1-mutated hepatocellular carcinoma through inhibition of tumor progression.

Revolutionizing Stage II Colorectal Cancer Prognostication: Validating Semantically-Enhanced AI for Risk Stratification
Gastroenterologyprognostic biomarkersdeep learning

Revolutionizing Stage II Colorectal Cancer Prognostication: Validating Semantically-Enhanced AI for Risk Stratification

By MedXY|Aug 4, 2026

A novel AI model, SÉMIL, integrating vision-language and multiple instance learning, improves prognostic accuracy for stage II colorectal cancer by refining risk stratification beyond current clinical assessments, especially within NCCN hig

Evaluating Pemetrexed Monotherapy and Combination Therapy with Carboplatin in Advanced Thyroid Cancer: A Retrospective Cohort Analysis
Diabetes & Endocrinologythyroid cancerPemetrexed

Evaluating Pemetrexed Monotherapy and Combination Therapy with Carboplatin in Advanced Thyroid Cancer: A Retrospective Cohort Analysis

By MedXY|Aug 4, 2026

This retrospective study assesses the efficacy and safety of pemetrexed, alone or combined with carboplatin, as salvage therapy for advanced thyroid cancer, showing promising response rates comparable to current second-line treatments.

Improved Survival in Unresectable Hepatocellular Carcinoma with Combined Transarterial Chemoembolization and Thermal Ablation: Insights from the Phase 3 TORCH Trial
Gastroenterologyhepatocellular carcinomarandomized clinical trial

Improved Survival in Unresectable Hepatocellular Carcinoma with Combined Transarterial Chemoembolization and Thermal Ablation: Insights from the Phase 3 TORCH Trial

By MedXY|Jul 30, 2026

The phase 3 TORCH trial demonstrates that adding selective radiofrequency ablation after transarterial chemoembolization significantly improves progression-free and overall survival in patients with unresectable liver-confined hepatocellula

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