500 articles · 20 / page
A prospective study identifies exhaustion, head and neck discomfort, and body image concerns as independent predictors of poor emotional functioning in differentiated thyroid carcinoma patients. These findings highlight actionable targets f
A nationwide French cohort study reveals that advanced NSCLC patients completing 2 years of pembrolizumab maintain excellent survival outcomes, with most remaining treatment-free and immunotherapy rechallenge being uncommon.
Researchers discovered that loss of GPRC5D, a key immunotherapy target in multiple myeloma, not only confers resistance to targeted therapies but actively promotes cancer cell proliferation and competitive fitness—creating a therapeutic par
This study identifies clinicopathologic factors linked to pre- and postoperative levels of circulating tumor HPV DNA (ctHPVDNA) in HPV-mediated oropharyngeal cancer patients treated with upfront surgery, offering insights for disease monito
A real-world study of 671 endometrial cancer patients reveals significant molecular heterogeneity. PTEN, ARID1A, and PIK3CA are the most prevalent biomarkers, while TP53 mutations and ERBB2 amplification cluster in advanced-stage and non-en
Researchers have developed an AI-powered framework that uncovers a non-linear relationship between tumor-stroma ratio and mortality in hepatocellular carcinoma, using a novel token-guided multimodal fusion approach to improve prognostic acc
This retrospective study challenges the assumption that prior radiation limits immunotherapy effectiveness in recurrent endometrial and cervical cancers, finding no significant difference in response rates or survival outcomes based on recu
A landmark multicohort study of 1,168 individuals reveals that gut microbiome diversity systematically declines across liver disease stages, with specific bacterial markers like Veillonella and functional metabolic shifts predicting disease
A large retrospective analysis of over 11,000 patients reveals that conversion to open surgery during minimally invasive left-sided pancreatectomy is independently associated with increased postoperative complications. The findings undersco
A prospective study evaluating at-home stool collection for gut microbiome research in gynecologic oncology demonstrates implementation feasibility with 61% patient enrollment. Provider engagement emerged as the strongest predictor of parti
A groundbreaking multicentre study develops a clinical-radiologic model integrating hypoxia and immune phenotype signatures to accurately predict prognosis in hepatocellular carcinoma patients treated with transarterial chemoembolisation, p
Patient-derived medullary thyroid cancer models preserved tumor heterogeneity, microenvironmental stem-like features, and variable tyrosine kinase inhibitor response, supporting more personalized preclinical testing.
This review evaluates the optimal sequencing of radiotherapy and immunotherapy in advanced NSCLC, highlighting real-world evidence from the OCEANUS study favoring sequential over concurrent administration.
This review analyzes community-validated strategies to improve biobanking engagement among Black women with endometrial cancer, highlighting return-of-value, transparency, and trust-building as essential components for reducing health dispa
This report examines spatial transcriptomic data from HER2+ gastric cancer patients to identify resistance mechanisms to trastuzumab and T-DXd, including EMT and ERAD pathway activation.
A nationwide cohort study highlights that thyroid cancer patients with permanent hypoparathyroidism face significantly elevated risks of kidney stones, renal failure, and major cardiovascular events, necessitating comprehensive long-term fo
A prospective study demonstrates that tumor-informed ctDNA-based minimal residual disease (MRD) testing significantly predicts recurrence and survival in HPV-independent HNSCC, offering a median five-month lead time over clinical detection
This review evaluates the prognostic value of Major Pathologic Response (MPR) in pancreatic ductal adenocarcinoma, analyzing its impact on survival and its potential to guide personalized adjuvant treatment strategies.
This study analyzes how cancer diagnosis timing varies after an emergency department visit, finding that breast cancer faces the longest delays while ovarian cancer is often diagnosed immediately. Factors like comorbidities and primary care
This review synthesizes recent qualitative and clinical evidence regarding the linguistic barriers between gynaecology providers and patients, emphasizing the impact of descriptive terminology on trust, diagnostic clarity, and maternal outc
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