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Indexing donor kidney parenchymal volume by recipient BMI via routine ultrasound strongly predicts one-year kidney graft function, offering a practical surrogate for graft-recipient size matching.
Italian data suggest prolonged warm ischemic times in donation after circulatory death do not compromise kidney and liver transplant outcomes when combined with advanced perfusion techniques, challenging traditional strict cutoffs.
The Semi-Elective Transplant Initiative (SETI) introduces a systems-based approach to deceased-donor kidney transplantation, improving logistics and graft utilization by shifting to proactive scheduling and expanded machine perfusion, witho
This study explores how physical activity influences lung and kidney function in COVID-19 survivors, showing active survivors had better lung outcomes but no significant kidney benefits, highlighting the importance of tailored rehabilitatio
New evidence suggests lower urine output thresholds than current standards better predict acute kidney injury, chronic kidney disease, and mortality in critically ill patients, urging redefinition of oliguria parameters in AKI diagnostics.
A validated set of 17 quality indicators (QIs) for lupus nephritis, derived from the 2025 EULAR recommendations, shows variable adherence in practice and an association between higher adherence and lower damage accrual in a tertiary-care co
This Swiss retrospective study reveals that while obesity in kidney transplant recipients increases early surgical complications and delayed graft function, it does not affect long-term patient or graft survival, suggesting obesity alone sh
This analysis of over 63,000 US liver transplants reveals that simultaneous liver-kidney transplantation (SLKT) confers significant survival benefit only in patients with severe renal dysfunction (eGFR <30), with no advantage in those wi
TBX2 is identified as a key transcription factor repressing vascular calcification by controlling RUNX2 and the inflammatory NLRP3 pathway, highlighting new therapeutic targets to reduce cardiovascular risk in CKD.
This study reveals how liver-sourced apolipoprotein J worsens diabetic kidney disease by impairing lipid regulation via TFEB pathways, highlighting a novel therapeutic target, MK53, for managing diabetic renal injury.
This study reveals that many patients with primary aldosteronism have inappropriately normal aldosterone levels and shows that modifying the aldosterone-to-renin ratio improves sensitivity in diagnosis without compromising specificity.
This study reveals that liver-secreted apolipoprotein J accumulates in renal tubules, disrupting TFEB-mediated lipid homeostasis and exacerbating diabetic kidney disease, highlighting a novel therapeutic target with the ApoJ antagonist MK53
A risk prediction model derived from the PEXIVAS trial estimates the 2-year relapse probability in ANCA-associated vasculitis, integrating clinical and laboratory factors to improve individualized patient management.
This study elucidates the distinct clinical, pathological, and prognostic differences between native and allograft BK polyomavirus nephropathy, highlighting the severity and poorer outcomes associated with native-kidney BKPyVN and stressing
This national matched cohort study highlights that dual kidney transplantation (DKT) offers improved graft and patient survival compared to single kidney transplantation (SKT) in select recipients, supporting its strategic use for hard-to-p
A 5-year real-world cohort study reveals that declines in CGM-derived time in range correlate with increased microvascular complications in type 1 diabetes, offering prognostic value beyond HbA1c.
A phase 2 randomized trial found that ilofotase alfa did not significantly reduce kidney injury or improve outcomes in high-risk patients undergoing on-pump cardiac surgery, though it was safe and well tolerated.
This study analyzes the epidemiology, treatment processes, and outcomes of critically ill cirrhosis patients undergoing continuous renal replacement therapy, highlighting high mortality rates, anticoagulation practices, and implications of
Following the 2023 US safety net policy for kidney after lung transplantation, a shift from simultaneous lung-kidney transplants to early kidney transplantation post lung transplant was observed, with improved short-term outcomes and reduce
Low-dose rivaroxaban failed to reduce cardiovascular events but increased major bleeding in advanced CKD patients at high cardiovascular risk, underscoring the need for cautious anticoagulant use.
