Section
This article reviews the development of high-avidity cathepsin-G-specific CAR T cells engineered with enhanced functional features to selectively target acute myeloid leukemia without hematopoietic toxicity, highlighting their preclinical e
Histidine-rich glycoprotein (HRG) directly modulates platelet adhesion and aggregation by binding platelet receptors GPIbα and GPIIb/IIIa, competing with key ligands VWF and fibrinogen, thus attenuating thrombus formation; reduced HRG in se
A comprehensive Danish nationwide study reveals that women with endometriosis face a significantly increased long-term risk of venous thromboembolism, underscoring the need for heightened clinical vigilance and tailored risk management.
This qualitative study explores patient and obstetric clinician perspectives on postpartum venous thromboembolism (VTE) risk communication and pharmacologic thromboprophylaxis, highlighting education gaps and the need for individualized ris
NEK7 promotes acquired lenvatinib resistance in hepatocellular carcinoma by phosphorylating EGFR at serine 1070, activating key signaling pathways. Blocking this interaction offers a promising therapeutic avenue to counteract resistance.
Metrnl reduces platelet activation and thrombus formation by promoting CD36 degradation, offering a promising therapeutic strategy for thrombotic diseases including acute myocardial infarction without increasing bleeding risk.
The DIADEMA trial demonstrates dulaglutide’s superiority over insulin in improving glycaemic variability, pancreatic function, and iron overload, without safety concerns, in adolescents with thalassaemia-induced diabetes.
This study compares US federally sponsored and industry-sponsored cancer clinical trials, highlighting differences in trial focus, populations, and interventions, and underscoring their complementary roles in advancing oncology research.
This study evaluates ovarian tissue cryopreservation (OTC) feasibility in girls and young women post-hematopoietic stem cell transplantation (HSCT), demonstrating OTC as a potential fertility salvage option despite reduced ovarian reserve a
This review explores the Global Lymphoma Registry Alliance’s roadmap for leveraging multinational real-world data collaborations to address lymphoma’s heterogeneity, optimize treatment strategies, and improve patient outcomes worldwide thro
Low-normal immunoglobulin levels, particularly IgA, measured up to a decade before diagnosis, are predictive of chronic lymphocytic leukemia risk through dual mechanisms involving monoclonal B-cell lymphocytosis and constitutional susceptib
Bispecific anti-BCMA/GPRC5D CAR T cells demonstrate high response rates and manageable safety in patients with relapsed/refractory multiple myeloma complicated by extraosseous extramedullary disease, a group with historically poor outcomes.
A nationwide French study reveals that nearly half of maternal deaths due to venous thromboembolism are preventable, emphasizing the importance of ongoing risk assessment and appropriate thromboprophylaxis during pregnancy and postpartum.
A retrospective study delineates relapse risks and survival outcomes in adult acute myeloid leukemia patients who achieve first complete remission without undergoing allogeneic stem cell transplantation, highlighting venetoclax’s role in re
Spatial remodeling of bone marrow in myelodysplastic neoplasms (MDS) reveals distinctive tissue-state signatures that better capture disease activity and predict therapeutic response beyond traditional blast counts.
This study compares outcomes of CAR T-cell therapy and allogeneic stem cell transplantation based on IPI risk factors in relapsed/refractory LBCL, highlighting favorable survival with CAR T-cell therapy in low-risk patients but advocating a
Mutant IDH1 in acute myeloid leukemia causes a reversible block in neutrophil differentiation by repressing myeloid progenitor transcriptional programs, highlighting a preleukemic defect with therapeutic implications.
A novel chemotherapy-free regimen combining mosunetuzumab with response-adapted polatuzumab vedotin and obinutuzumab shows high complete response rates and durable progression-free survival in untreated indolent B-cell NHL with favorable sa
Blood or marrow transplant recipients face an increased risk of skin cancers. This study develops validated risk models to identify high-risk patients for basal cell carcinoma, squamous cell carcinoma, and melanoma to optimize surveillance
A case series assessing the safety and efficacy of low-dose blinatumomab in 15 patients with multidrug-resistant rheumatoid arthritis showed synovial B-cell depletion, reduced disease activity, and improved response to previously ineffectiv
