Gastroenterology
Latest news
363 articles · 20 / page
Duct-to-Mucosa versus Other Pancreaticojejunostomy Techniques for Preventing Postoperative Pancreatic Fistula: Updated Evidence and Clinical Insights
This Cochrane review update evaluates duct-to-mucosa pancreaticojejunostomy compared to other anastomotic techniques following pancreaticoduodenectomy for preventing postoperative pancreatic fistula, finding very low-certainty evidence and
Da Vinci-Assisted vs Laparoscopic Nissen Fundoplication for GERD: A Critical Systematic Review and Meta-Analysis
Four RCTs comparing robotic and laparoscopic Nissen fundoplication for GERD show equivalent patient outcomes but longer operative times and higher costs with robotics, questioning its routine use.
Probiotics and Cognitive Health: Evaluating the Evidence from Systematic Reviews and Meta-Analyses
An umbrella review synthesizes evidence from 156 RCTs assessing probiotics’ effects on cognitive-related outcomes, showing moderate- to high-quality support for cognitive benefits but highlighting need for further trials on strains and dosi
Proton Pump Inhibitors and Clostridioides difficile Infection: A Comprehensive Meta-Analysis of Randomized Controlled Trials Reveals No Increased Risk
This systematic review and meta-analysis of randomized controlled trials finds no significant association between proton pump inhibitor use and increased risk of Clostridioides difficile infection, challenging earlier observational data and
Diagnostic Accuracy of MRI and CT in Evaluating Nonviability of Disappearing Colorectal Liver Metastases: An International Prospective Study
Combining MRI and CT improves detection of nonviable disappearing colorectal liver metastases but does not reliably confirm nonviability, challenging the management of such lesions post-chemotherapy.
Postoperative Pulmonary Complications in Conventional Laparoscopic vs Robot-Assisted Abdominal Surgery: Incidence, Risk Factors, and Clinical Implications
This review synthesizes evidence comparing postoperative pulmonary complications (PPCs) between robot-assisted surgery (RAS) and conventional laparoscopic surgery (CLS) in abdominal procedures, highlighting the pivotal role of ventilation d
Prehabilitation in Sarcopenic Patients Undergoing Major Hepatectomy: Evidence from the PREHEP Trial
A 6-week multimodal prehabilitation program combining exercise and nutrition significantly reduces postoperative morbidity in sarcopenic patients undergoing major liver resection, highlighting a promising strategy to improve surgical outcom
Risk Stratification of Hepatocellular Carcinoma in Chronic Hepatitis B Patients with Metabolic Dysfunction and MASLD: Validating the PAGE-B Score
Metabolic dysfunction and MASLD elevate hepatocellular carcinoma risk in chronic hepatitis B patients. The PAGE-B score effectively stratifies this risk, especially in non-cirrhotic patients, while cirrhotic patients still require careful m
Simplifying Ulcerative Colitis Treatment: Evaluating a Single 1600 mg 5-ASA Tablet Regimen in the EASI Trial
The EASI trial compared a once-daily 1600 mg 5-ASA tablet with the conventional three 800 mg tablet regimen for ulcerative colitis, finding similar adherence and relapse rates, suggesting a feasible simpler alternative.
IL23R Polymorphism as a Genetic Predictor of Paradoxical Psoriasis in Anti-TNFα-Treated IBD Patients
The IL23R1142G>A genetic variant strongly predicts paradoxical psoriasis in inflammatory bowel disease patients undergoing anti-TNFα therapy, guiding personalized treatment decisions.
Persistent High Mortality in Severe Alcohol-Associated Hepatitis: Insights from a Five-Decade Meta-Analysis
This meta-analysis reveals that short-term mortality in severe alcohol-associated hepatitis remains high, with no significant improvement over the past four decades despite advances in care, underscoring the urgent need for better therapies
Obeticholic Acid Non-Response Signals Higher Clinical Risk in Primary Biliary Cholangitis
In primary biliary cholangitis (PBC) patients treated with obeticholic acid (OCA), biochemical non-response strongly predicts a higher risk of clinical events including liver decompensation and mortality, underscoring the need for improved
Gut Microbiota Dysbiosis in Cirrhotic Portal Hypertension: Unraveling Microbial Contributions to Disease Progression
Altered gut microbiota composition and metabolism exacerbate cirrhotic portal hypertension, highlighting potential microbiome-targeted therapies to mitigate disease progression.
Optimizing Encapsulated Faecal Microbiota Transplantation for Clostridioides difficile Infection: Empirical Donor Selection and Two-Dose Regimen Enhance Cure Rates
This study demonstrates that empirical donor exclusion combined with a two-dose capsule regimen significantly improves cure rates in Clostridioides difficile infection treated with encapsulated faecal microbiota transplantation (FMT).
Opioid Use in Rome IV Irritable Bowel Syndrome: Prevalence and Impact on Quality of Life and Healthcare in the UK
One in five UK patients with Rome IV IBS regularly use opioids, associated with worse quality of life, more psychological distress, and increased healthcare costs, highlighting a critical need for opioid stewardship in IBS management.
Noninvasive Biomarkers Track Semaglutide Efficacy in Metabolic Dysfunction-Associated Steatohepatitis
A phase 2b trial demonstrates that several noninvasive tests reliably reflect treatment response to semaglutide in patients with metabolic dysfunction-associated steatohepatitis, correlating with histologic improvements over 72 weeks.
Gut Microbiota as a Key Determinant of Quality of Life Impairment in Inflammatory Bowel Disease
A recent cross-sectional study reveals that alterations in gut microbiota correlate more strongly with impaired health-related quality of life in IBD patients than clinical disease activity, suggesting novel microbial therapeutic targets be
FDA Approves Golimumab (Simponi) for Pediatric Ulcerative Colitis: A New Therapeutic Option
The FDA has approved golimumab (Simponi) for treating moderately to severely active ulcerative colitis in children weighing at least 15 kg, based on the PURSUIT 2 phase 3 study demonstrating significant clinical remission and safety.
Menopausal Hormone Therapy and Reduced Risk of Upper Gastrointestinal Cancers: Insights From a Large Nordic Population Study
A large Nordic study finds menopausal hormone therapy reduces the risk of esophageal and gastric cancers by up to 30%, especially with combined estrogen-progestin systemic formulations.
Browse by specialty
Open language-specific specialty feeds and department pages.