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This review synthesizes findings on how pregnancy biomarkers, particularly sFlt-1 and hs-cTnI, serve as early indicators of long-term maternal cardiovascular risk, offering a unique window for sex-specific prevention.
This review synthesizes evidence that intramuscular adipose tissue (IMAT) accumulation, driven by fibroadipogenic progenitors, is a primary driver of limb dysfunction in PAD/CLTI, identifying IMAT as a novel therapeutic target.
This review synthesizes recent findings identifying the CEBPA-ORM1 axis as a critical suppressor of alcohol-associated liver disease, highlighting its potential as both a therapeutic target and a diagnostic biomarker for disease staging.
This article synthesizes evidence from a large-scale individual participant data meta-analysis, demonstrating that early perihematomal edema growth (at 24 and 72 hours) is an independent predictor of death and disability after intracerebral
This review synthesizes evidence on the impact of kidney function, BMI, and anemia on plasma p-tau217 diagnostic accuracy, advocating for subgroup-specific cutoff strategies to improve clinical outcomes.
This review analyzes the LIDA trial findings, demonstrating that an abbreviated 3-month romosozumab course followed by denosumab is non-inferior to the standard 12-month regimen in increasing total hip bone mineral density, potentially redu
This review evaluates the LIDA trial’s findings that 3 months of romosozumab followed by denosumab is non-inferior to 12 months of romosozumab, offering a cost-effective strategy to mitigate long-term side effects.
A pivotal randomized clinical trial reveals that targeted training of the ipsilesional arm in chronic stroke patients with severe hemiparesis significantly improves motor speed and hand function, with benefits sustained for six months.
This clinical review synthesizes findings from the PRETHYR study on antithyroid drug use in pregnant women, highlighting treatment transitions, biochemical predictors, and the impact of specialist-led management in Denmark.
This review synthesizes the landmark RADIANT trial findings, demonstrating the efficacy of transitioning patients from multiple daily injections to tubeless automated insulin delivery, while integrating broader evidence on genetic susceptib
This review evaluates the breakthrough ECG2HF model, a publicly available AI tool that outperforms standard clinical scores in predicting 10-year heart failure risk using 12-lead ECG waveforms.
This review analyzes the SHaRe registry data, revealing that sarcomeric HCM represents a more aggressive clinical phenotype with earlier onset and higher HCM-related mortality compared to nonsarcomeric cases, which are more heavily influenc
Preclinical studies demonstrate that the nucleotide analogue bemnifosbuvir effectively suppresses Hepatitis E virus (HEV) replication, showing synergistic potential with ribavirin and a high genetic barrier to resistance.
This review synthesizes evidence distinguishing perivascular space enlargement mechanisms in cerebral amyloid angiopathy (CAA) versus deep perforator arteriopathy (DPA), highlighting the diagnostic utility of CSF Aβ42/40 ratios in vascular
This review synthesizes recent PubMed-indexed evidence on autologous blood-derived therapies, such as PRP and PRF, highlighting their role in accelerating wound healing through growth factor signaling and cellular recruitment.
This review analyzes the shifting landscape of SMA therapy using data from 2,140 patients, highlighting the transition between nusinersen, risdiplam, and onasemnogene abeparvovec and the factors driving treatment switches.
This study demonstrates that while MS genetic risk factors are largely shared across ancestral groups, their predictive power and population-level impact vary significantly between European, South Asian, and African populations.
This review evaluates a recent 2-year pilot RCT on low-dose lithium carbonate for MCI, synthesizing its findings with emerging evidence on Aβ clearance, gut-brain axis modulation, and multimodal disease forecasting.
This review synthesizes findings from a large-scale comparison of five major thyroid ultrasound risk stratification systems (RSSs), evaluating how nodule size and standardized lexicon influence sensitivity, specificity, and unnecessary biop
This evidence-based review examines the debate over adding preventive PCI to medical therapy for vulnerable plaques, analyzing the PREVENT trial results and the role of intracoronary imaging in risk stratification.
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