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This nationwide retrospective study in France highlights the rare but severe incidence of tuberculosis (TB) in Allo-HSCT recipients, identifying birth in high-prevalence countries as a primary risk factor and emphasizing the need for target
This review explores oncofetal chondroitin sulfate (ofCS) as a revolutionary AML target. Unlike traditional antigens, ofCS is absent in normal bone marrow, allowing antibody-drug conjugates to eliminate leukemia cells with minimal hematotox
This review evaluates the evidence for prophylactic haemostasis during endobronchial biopsy, centered on the PROTECT trial results, while integrating contemporary data on procedural safety, pre-procedural screening, and technical optimizati
This clinical update examines the association between hearing impairment and visual rehabilitation outcomes, revealing that concurrent hearing loss significantly reduces the likelihood of functional improvement, independent of hearing aid u
This review explores the transcriptomic distinctions between vocal fold polyps and Reinke’s edema, focusing on the upregulation of COL1A1, FN1, and MMP-9 in polyps as key diagnostic and mechanistic markers.
This review synthesizes recent evidence on the financial impact of CMS billing reforms in hernia surgery and the efficacy of regional collaboratives in improving colorectal cancer outcomes.
This review synthesizes current evidence on endometrial polyps, focusing on diagnostic accuracy via sonohysterography and the shift toward office-based hysteroscopic polypectomy for abnormal uterine bleeding and infertility.
This review evaluates how deep learning-assisted delta radiomics on MRI, combined with AFP response, provides a non-invasive, high-accuracy prediction of pathological complete response in unresectable HCC undergoing conversion immunotherapy
This review details a breakthrough in esophageal adenocarcinoma treatment, identifying the APE1-SOX9 axis as a primary driver of chemoresistance and demonstrating how targeting APE1’s redox function can sensitize tumors to oxaliplatin
This review synthesizes findings on how periventricular white matter hyperintensities (PWMHs) drive cognitive impairment in Aβ-negative individuals through distinct metabolic mediation and direct structural pathways, highlighting the clinic
This post hoc analysis of the CREDENCE trial reveals that low-normal sodium intake increases cardiovascular risk in T2D and CKD, a risk significantly mitigated by canagliflozin, while renal protection remains consistent across sodium intake
This review analyzes multinational data showing a significant decline in cardiovascular mortality among diabetes patients, alongside a concerning rise in dementia-related deaths and the emergence of cancer as a leading cause of mortality in
This review analyzes the real-world one-year outcomes and healthcare costs for HFrEF patients on quadruple therapy, revealing significant residual risk despite optimized pharmacologic management.
This review explores how adipocyte-derived small extracellular vesicles (sEVs) use surface-bound adiponectin to protect the heart, and how diabetes-induced GRK2 upregulation disrupts this vital signaling pathway, leading to ischemic heart f
A large-scale cohort study reveals that solid organ transplant recipients with pre-existing cancer histories face significantly elevated risks for subsequent malignancies, particularly recurring or de novo cancers of the same type, necessit
This review synthesizes evidence comparing SGLT2 inhibitors and GLP-1 receptor agonists, highlighting a significant reduction in chronic kidney disease and acute kidney injury risks associated with SGLT2i initiation.
This review evaluates a novel open-source extraction pipeline designed to standardize and automate the processing of complex HSCT registry data, enhancing reproducibility and precision in clinical outcomes research.
A landmark study identifies a decade-long conserved sequence of disease progression in IPF, revealing that DLCO decline precedes FVC impairment by years, providing a new framework for early diagnosis and clinical trial design.
Recent data from the NIH All of Us Research Program indicates that Fuchs’ Endothelial Corneal Dystrophy (FECD) is associated with a significantly higher prevalence of cardiometabolic comorbidities, suggesting a systemic component to t
This review analyzes the high prevalence of anxiety and depression in patients with Retrograde Cricopharyngeus Dysfunction (RCPD) and evaluates the significant, sustained mental health improvements following cricopharyngeal botulinum toxin
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