Allergy & Immunology
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Alopecia Areata Linked to Elevated Risk of Microscopic Colitis and Other Immune-Mediated GI Disorders: Clinical Insights
A large retrospective cohort study identifies a significant association between alopecia areata and increased risks of microscopic colitis, celiac disease, Crohn’s disease, eosinophilic esophagitis, and ulcerative colitis, highlighting the
Tumor Microenvironment-Responsive Mn-Based Nanoplatform Activates cGAS-STING Pathway Coupled with Metabolic Interference for Enhanced Antitumor Therapy
A novel Mn-based nanoplatform, LT@MnO@MON-HA (LMMH), responsive to tumor microenvironment triggers metabolic disruption and robust cGAS-STING activation, potentiating chemodynamic therapy and immunotherapy for improved tumor suppression.
Manganese: A Potent Catalyst Enhancing Cancer Immunotherapy
Manganese and its nanoparticles play a pivotal role in cancer immunotherapy by modulating immune pathways, reshaping the tumor microenvironment, and serving as effective adjuvants and drug carriers, offering promising avenues to overcome cu
Clonal Hematopoiesis and Its Link to Severe Cytokine Release Syndrome in CAR T-Cell Therapy Recipients
Clonal hematopoiesis (CH) occurs frequently in patients receiving CD19 or BCMA CAR T therapy and correlates with a higher risk of severe cytokine release syndrome (CRS), suggesting CH as a potential biomarker for CRS risk and a target for p
Rentosertib: The First AI-Discovered TNIK Inhibitor Shows Promise in Idiopathic Pulmonary Fibrosis Phase 2a Trial
Rentosertib, an AI-designed TNIK inhibitor, demonstrated safety and preliminary efficacy in idiopathic pulmonary fibrosis in a randomized phase 2a trial, marking a milestone in AI-driven drug development for progressive lung diseases.
Dual JAK and ROCK Inhibition with CPL’116: A Promising Advance for Methotrexate-Refractory Rheumatoid Arthritis
CPL’116, a novel dual JAK and ROCK inhibitor, demonstrates dose-dependent efficacy and a favorable safety profile in rheumatoid arthritis patients inadequately responsive to methotrexate, without the typical lipid or creatine kinase abnorma
Stay Young, Live Longer: Protecting Your Brain and Immune System Cuts Death Risk by 56%
A major study reveals maintaining youthful brains and strong immune systems significantly lowers mortality risk. Learn harmful habits to avoid and simple lifestyle changes to boost brain and immunity for longevity.
Emerging APRIL-Targeted Therapies in IgA Nephropathy and IgA Vasculitis Nephritis: Clinical Advances with Zigakibart, Sibeprenlimab, and Telitacicept
Recent clinical trials of APRIL-targeted monoclonal antibodies—zigakibart, sibeprenlimab, and telitacicept—demonstrate safety and significant proteinuria reduction in IgA nephropathy and IgA vasculitis nephritis, offering promising disease-
PANLAR 2025 Recommendations for Polyarticular Juvenile Idiopathic Arthritis in Latin America — Practical, Evidence-Based Guidance for Resource-Variable Settings
PANLAR’s 2025 evidence-based recommendations for non-systemic polyarticular JIA emphasize early treat-to-target care using methotrexate, targeted escalation to biologics when needed, region-sensitive alternatives (leflunomide, triple nbDMAR
Emerging Roles of Circular RNAs in Cancer and Immunotherapy: Mechanisms and Clinical Potential
Circular RNAs (circRNAs) are pivotal regulators in cancer biology and immunotherapy, acting through mechanisms such as miRNA sponging, protein interactions, and translation. Their modulation of tumor immune microenvironment offers promising
Persistent Penicillin Allergy Following Epstein-Barr Virus-Associated Rashes: Evidence and Clinical Implications
Nearly half of adolescents and adults who developed penicillin-associated rashes during EBV infection exhibit persistent hypersensitivity, challenging the notion of transient viral exanthem-related allergies.
Asthma and the Risk of Degenerative Valvular Heart Disease: Insights from a Large Prospective Cohort Study
This study demonstrates that asthma modestly increases the risk of degenerative valvular heart diseases, highlighting the need for cardiovascular vigilance in asthmatic individuals.
Diverging Pediatric Recommendations on COVID-19 Vaccination: The AAP Advocates Routine Immunization for Young Children Amid Federal Policy Shift
The American Academy of Pediatrics recommends COVID-19 vaccination for all young children aged 6-23 months, diverging from current CDC policies that advise shared decision-making for healthy children. This review analyzes epidemiologic data
Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression: Insights from the BENEFIT Study
Higher baseline serum alpha-linolenic acid levels predict reduced multiple sclerosis activity, relapses, and disability progression up to 11 years post clinical onset in a large prospective study.
Phase 3 Trial of Inhaled Molgramostim in Autoimmune Pulmonary Alveolar Proteinosis: A Synthesis of Recent Evidence
Inhaled molgramostim, a recombinant human GM-CSF, significantly improves lung gas transfer and quality of life in autoimmune pulmonary alveolar proteinosis, with safety comparable to placebo.
Long-term Ambient Air Pollution Exposure and Asthma Exacerbation Risk in Women: Evidence from the Nurses’ Health Study II
Long-term exposure to ambient air pollutants, notably nitrogen dioxide, is linked to increased asthma exacerbations in women, independent of plant-based diet adherence, underscoring the need for stricter air quality standards and targeted r
New insights into food allergy mechanisms—DPEP1, leukotrienes, and the potential of Zileuton
Two Science papers identify intestinal leukotrienes and DPEP1 gene variants as drivers of oral anaphylaxis in mice, and show that the asthma drug Zileuton largely prevents food‑induced shock in animals, opening new avenues for human trials.
Revolutionizing Ankylosing Spondylitis Assessment: AI-Driven Severity Inspection Model Enhances Diagnostic Precision
An AI-based model for assessing ankylosing spondylitis severity using spinal X-rays and mSASSS demonstrates high accuracy, offering clinicians a rapid, reliable tool and reducing human resource demands.
Managing Allergies During Pregnancy: Key Tips for Expectant Mothers
Explore how pregnant women can manage allergies to pollen, dust mites, and pet dander effectively to ensure health and comfort for themselves and their babies.
Emergency Response for Children Allergic to Mosquito and Insect Bites
Children are prone to allergic reactions after mosquito or insect bites. This guide explains how to manage symptoms promptly and effectively to prevent complications.
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