Allergy & Immunology
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Stay Young, Live Longer: Protecting Your Brain and Immune System Cuts Death Risk by 56%
A major study reveals maintaining youthful brains and strong immune systems significantly lowers mortality risk. Learn harmful habits to avoid and simple lifestyle changes to boost brain and immunity for longevity.
Emerging APRIL-Targeted Therapies in IgA Nephropathy and IgA Vasculitis Nephritis: Clinical Advances with Zigakibart, Sibeprenlimab, and Telitacicept
Recent clinical trials of APRIL-targeted monoclonal antibodies—zigakibart, sibeprenlimab, and telitacicept—demonstrate safety and significant proteinuria reduction in IgA nephropathy and IgA vasculitis nephritis, offering promising disease-
PANLAR 2025 Recommendations for Polyarticular Juvenile Idiopathic Arthritis in Latin America — Practical, Evidence-Based Guidance for Resource-Variable Settings
PANLAR’s 2025 evidence-based recommendations for non-systemic polyarticular JIA emphasize early treat-to-target care using methotrexate, targeted escalation to biologics when needed, region-sensitive alternatives (leflunomide, triple nbDMAR
Emerging Roles of Circular RNAs in Cancer and Immunotherapy: Mechanisms and Clinical Potential
Circular RNAs (circRNAs) are pivotal regulators in cancer biology and immunotherapy, acting through mechanisms such as miRNA sponging, protein interactions, and translation. Their modulation of tumor immune microenvironment offers promising
Persistent Penicillin Allergy Following Epstein-Barr Virus-Associated Rashes: Evidence and Clinical Implications
Nearly half of adolescents and adults who developed penicillin-associated rashes during EBV infection exhibit persistent hypersensitivity, challenging the notion of transient viral exanthem-related allergies.
Asthma and the Risk of Degenerative Valvular Heart Disease: Insights from a Large Prospective Cohort Study
This study demonstrates that asthma modestly increases the risk of degenerative valvular heart diseases, highlighting the need for cardiovascular vigilance in asthmatic individuals.
Diverging Pediatric Recommendations on COVID-19 Vaccination: The AAP Advocates Routine Immunization for Young Children Amid Federal Policy Shift
The American Academy of Pediatrics recommends COVID-19 vaccination for all young children aged 6-23 months, diverging from current CDC policies that advise shared decision-making for healthy children. This review analyzes epidemiologic data
Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression: Insights from the BENEFIT Study
Higher baseline serum alpha-linolenic acid levels predict reduced multiple sclerosis activity, relapses, and disability progression up to 11 years post clinical onset in a large prospective study.
Phase 3 Trial of Inhaled Molgramostim in Autoimmune Pulmonary Alveolar Proteinosis: A Synthesis of Recent Evidence
Inhaled molgramostim, a recombinant human GM-CSF, significantly improves lung gas transfer and quality of life in autoimmune pulmonary alveolar proteinosis, with safety comparable to placebo.
Long-term Ambient Air Pollution Exposure and Asthma Exacerbation Risk in Women: Evidence from the Nurses’ Health Study II
Long-term exposure to ambient air pollutants, notably nitrogen dioxide, is linked to increased asthma exacerbations in women, independent of plant-based diet adherence, underscoring the need for stricter air quality standards and targeted r
New insights into food allergy mechanisms—DPEP1, leukotrienes, and the potential of Zileuton
Two Science papers identify intestinal leukotrienes and DPEP1 gene variants as drivers of oral anaphylaxis in mice, and show that the asthma drug Zileuton largely prevents food‑induced shock in animals, opening new avenues for human trials.
Revolutionizing Ankylosing Spondylitis Assessment: AI-Driven Severity Inspection Model Enhances Diagnostic Precision
An AI-based model for assessing ankylosing spondylitis severity using spinal X-rays and mSASSS demonstrates high accuracy, offering clinicians a rapid, reliable tool and reducing human resource demands.
Managing Allergies During Pregnancy: Key Tips for Expectant Mothers
Explore how pregnant women can manage allergies to pollen, dust mites, and pet dander effectively to ensure health and comfort for themselves and their babies.
Emergency Response for Children Allergic to Mosquito and Insect Bites
Children are prone to allergic reactions after mosquito or insect bites. This guide explains how to manage symptoms promptly and effectively to prevent complications.
Understanding and Managing Children’s Allergic Reactions to Mosquito Bites
Explore why children are more prone to allergic reactions from mosquito bites and learn effective prevention and treatment strategies.
Low-Dose Interleukin-2: Unlocking Immune Modulation Across Autoimmune, Neurodegenerative, Metabolic, Transplant, and Inflammatory Diseases
Low-dose IL-2 immunotherapy demonstrates broad, disease-modifying effects by selectively expanding regulatory T cells (Tregs), offering a promising strategy across diverse diseases including autoimmunity, neurodegeneration, metabolic dysfun
Psychedelics Target Neuroimmune Interactions to Limit Fear
Research reveals how psychedelics modulate immune-to-brain communication to reduce fear, offering new therapeutic avenues for stress-related psychiatric disorders.
Empowering Parents: Acceptance and Commitment Therapy for Children With Asthma and ADHD
A randomized clinical trial demonstrates that an Acceptance and Commitment Therapy-based parenting program reduces health care use, improves asthma control, and alleviates ADHD symptoms in children with both conditions.
Therapeutic Strategies for Disease-Modifying Therapy Management in Pregnant Women With Multiple Sclerosis: Relapse Risk and Clinical Implications
Managing disease-modifying therapies (DMTs) during pregnancy in women with multiple sclerosis significantly affects relapse risk, with anti-CD20 strategies demonstrating superior protection compared to other approaches.
Peanut Intake in Infants Remains Low Despite Updated Allergy Prevention Guidelines
Despite recommendations for early allergen introduction, peanut intake among US infants remains low, with significant disparities by age and ethnicity. Tree nut and egg consumption trends also reveal notable demographic and temporal differe
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