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A prospective cohort study identifies biomarker signatures for host resistance, disease tolerance, and damage in sepsis, revealing associations with mortality and sepsis subtypes.
A randomized clinical trial found that FMT did not significantly decolonize MDROs or reduce AMR genes in GI disease patients, though it modulated gut microbiome composition.
A study reveals CD16+ γδ T cells as key mediators of antibody-dependent cellular cytotoxicity in HBV infection, correlating with reduced viral replication and offering new therapeutic targets.
A multicenter study reveals that culturally and linguistically diverse patients with sepsis had lower in-hospital mortality and shorter ICU stays compared to non-CaLD patients, challenging prior assumptions about healthcare disparities.
A real-world study reveals FCN/GCV combination therapy enhances 1-year survival in HHV-6B encephalitis post-CBT, particularly after neutrophil engraftment, compared to monotherapy. Findings underscore the need for tailored antiviral strateg
A multicenter European cohort study demonstrates that antifungal treatment significantly reduces 60-day mortality in COVID-19-associated pulmonary aspergillosis (CAPA), particularly in immunocompromised patients. Key findings underscore the
A large-scale retrospective cohort study demonstrates that 9-valent HPV vaccination in males aged 9-26 years is associated with a 46% reduction in HPV-related cancer risk. The findings support sex-neutral HPV vaccination strategies and high
A prospective study of 47 patients reveals that white blood cell SPECT/CT demonstrates superior sensitivity and specificity compared to conventional MRI for initial diagnosis of diabetic foot osteomyelitis. While both modalities perform equ
A 20-year retrospective study of 6,452 solid organ transplant patients reveals hepatitis E infection rates of 3.5%, with chronicity rates exceeding 65%. The findings highlight the critical importance of HEV screening and the effectiveness o
A randomized trial of 399 adults with long COVID fatigue found that fluvoxamine significantly reduced fatigue severity at 60 and 90 days compared to placebo, while metformin showed no benefit. The study represents a potential breakthrough i
The SECRETO study reveals that infections within the preceding week significantly increase the risk of cryptogenic ischemic stroke in patients aged 18–49, with elevated von Willebrand Factor and Factor VIII levels serving as critical biomar
This review analyzes a decade-long nationwide study on TB after Allo-HSCT in France, revealing a 60/100,000 incidence rate, high extrapulmonary involvement, and the critical need for screening patients from high-incidence regions.
A prospective Kenyan cohort study identifies that post-tuberculosis lung disease (PTLD) affects 50% of survivors, driven by divergent transcriptomic signatures: early pro-fibrotic inflammation in restrictive phenotypes and persistent interf
Researchers have developed and validated the Long-term Pneumonia Mortality Index (L-PMI), a clinical tool that accurately predicts mortality up to one year following hospital discharge for community-acquired pneumonia, including COVID-19 ca
The SECRETO study demonstrates that infections within the preceding week increase the odds of cryptogenic ischemic stroke by 2.6-fold in young adults, primarily driven by transient increases in von Willebrand Factor and Factor VIII levels.
This nationwide retrospective study in France highlights the rare but severe incidence of tuberculosis (TB) in Allo-HSCT recipients, identifying birth in high-prevalence countries as a primary risk factor and emphasizing the need for target
A randomized clinical trial indicates that neither metformin nor ursodeoxycholic acid (UDCA) significantly improves recovery from postacute sequelae of SARS-CoV-2 (PASC) compared to placebo, highlighting the ongoing challenge of finding eff
Preclinical studies demonstrate that the nucleotide analogue bemnifosbuvir effectively suppresses Hepatitis E virus (HEV) replication, showing synergistic potential with ribavirin and a high genetic barrier to resistance.
A comprehensive meta-analysis of 121.8 million individuals confirms that RSV vaccines are approximately 75% effective against hospitalization and severe disease in older adults, despite low global uptake and a rare risk of Guillain-Barré sy
This review synthesizes findings from the CLEAN-IT trial and historical data to evaluate the impact of chlorhexidine bathing on nosocomial infections, MDR pathogens, and reserve antibiotic consumption in critically ill patients.
