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This article explores the role of the macrophage YTHDC1/TIGAR/NF-κB axis in pulmonary hypertension and highlights its potential as a therapeutic target to mitigate inflammation-driven vascular remodeling.
The University of California, Irvine Corneal Cystine Crystal Score (UCI CCCS) is validated as a reliable slit-lamp grading tool correlating with corneal densitometry and symptoms in cystinosis, though not visual acuity, highlighting its val
This study reveals that psychosocial stress induces vocal fold epithelial barrier dysfunction irrespective of microbiota presence, while microbiota presence uniquely promotes stress-induced epithelial proliferation in vocal folds, suggestin
The STOPS trial demonstrates noninferiority of subtotal colectomy with cecorectal anastomosis compared to total colectomy with ileorectal anastomosis for refractory slow-transit constipation at 1 year, balancing symptom relief with postoper
A randomized trial shows that intraoperative Lugol’s iodine staining during LEEP increases positive resection margins and should not be routinely applied, despite reducing postoperative bleeding duration.
The PIONIR randomized crossover trial demonstrates that a specific Tasty&Healthy diet significantly reduces fecal calprotectin levels, a marker of gut inflammation, in first-degree relatives at high risk for Crohn’s disease, sugge
A randomized clinical trial demonstrates that a self-guided internet intervention significantly reduces seizure frequency and improves anxiety in adults with functional seizures, offering a scalable treatment alternative to standard care.
This study evaluates semaglutide’s benefits over dulaglutide or liraglutide among diabetic hemodialysis patients, highlighting improved survival, reduced hospitalizations, and greater weight loss with semaglutide.
The DANCODE trial demonstrates that combined vitamin K2 and D3 supplementation reduces the progression of severe coronary artery calcification over 24 months without increasing noncalcified plaque burden, offering a promising adjunctive str
This study assesses the global track measurement against traditional imaging metrics to better predict engagement risk in anterior shoulder instability due to bipolar bone loss, highlighting its potential and need for further validation.
This study compares the effectiveness of inpatient rehabilitation facilities and skilled nursing facilities on functional recovery after acute stroke, showing inpatient care offers greater long-term home time.
Surgical trauma from oral cancer reconstruction disrupts oral microbiota; staged oral irrigation, especially using bipolar water, supports microbial stabilization, lowers fungal presence, and improves patient comfort, aiding postoperative r
This review synthesizes phase 3 clinical evidence comparing divarasib, sotorasib, and adagrasib for KRAS G12C-mutated NSCLC, highlighting divarasib’s superior efficacy and safety, dose optimization insights, real-world data, and trans
This trial shows that a six-month eHealth-guided exercise program significantly improves peak oxygen uptake and mental health quality of life in adults recovering from COVID-19, outperforming standard physical activity advice.
A multicentre retrospective study shows early controlled mobilisation in nonoperatively treated Mason type I and II radial head fractures leads to modest improvements in function, pain, and return to work times, with no significant increase
A novel polyurethane resin cement incorporating 3% DMAHDM exhibits potent antibacterial effects, maintains strong mechanical properties, and offers promising dual-action caries prevention for indirect restorations.
Two phase 3 trials establish remibrutinib, a BTK inhibitor, as more effective and better tolerated than teriflunomide in relapsing multiple sclerosis, supporting its potential as a new oral treatment.
A concise guide to the new AAP-endorsed curriculum framework that standardizes advocacy training in pediatric residency and fellowships using a socioecological model and practical, competency-linked tools for graduate medical education.
A 10-year follow-up of early rheumatoid arthritis patients treated with a treat-to-target strategy shows sustained remission leads to lasting clinical, structural, and functional benefits, supporting current treatment guidelines.
Recent large-cohort analyses reveal that donor hospital distance from OPO headquarters does not increase deceased donor kidney nonuse, while policy changes like KAS250 temporarily raise nonuse rates but overall kidney utilization continues
