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Enlarged Perivascular Spaces as Early Neurovascular Biomarkers in Alzheimer Disease: Integrating Serum and MRI Findings from Multicultural Cohorts
Enlarged perivascular spaces (EPVS) correlate with serum biomarkers of neuroinflammation and amyloid pathology and associate with cognitive impairment, supporting their role as early MRI markers for Alzheimer disease (AD) vascular contribut
Neoadjuvant TAR-200 Plus Cetrelimab versus Cetrelimab Monotherapy in Muscle-Invasive Bladder Cancer Ineligible for Cisplatin: Interim Phase 2 Trial Analysis
Interim results from the phase 2 SunRISe-4 trial demonstrate that neoadjuvant TAR-200 combined with cetrelimab significantly improves pathological complete response rates versus cetrelimab alone in muscle-invasive bladder cancer patients in
Clinical Decision Tool Integrating Decision Tree, Point-of-Care CRP Testing, and Safety Netting to Optimize Antibiotic Use in Acutely Ill Children: Evidence from the ARON Pragmatic Trial and Contextual Literature
The ARON trial demonstrated that a clinical decision tool combining decision tree, point-of-care CRP testing, and safety-netting advice safely reduces antibiotic prescribing in acutely ill children without delaying recovery or increasing he
Vericiguat in Chronic Heart Failure with Reduced Ejection Fraction: Insights from the VICTOR Phase 3 Trial
The VICTOR trial evaluated vericiguat in HFrEF patients without recent worsening, showing no significant reduction in composite cardiovascular death or heart failure hospitalization, but fewer cardiovascular and all-cause deaths with accept
Once-Daily Oral Icotrokinra vs Placebo and Deucravacitinib in Moderate-to-Severe Plaque Psoriasis: Insights from ICONIC-ADVANCE 1 & 2 Phase 3 Trials
ICONIC-ADVANCE 1 & 2 phase 3 trials demonstrate that once-daily oral icotrokinra significantly improves skin clearance with superior efficacy and favorable safety compared to placebo and deucravacitinib in moderate-to-severe plaque psoriasi
Diagnostic Accuracy of MRI and CT in Evaluating Nonviability of Disappearing Colorectal Liver Metastases: An International Prospective Study
Combining MRI and CT improves detection of nonviable disappearing colorectal liver metastases but does not reliably confirm nonviability, challenging the management of such lesions post-chemotherapy.
Postoperative Pulmonary Complications in Conventional Laparoscopic vs Robot-Assisted Abdominal Surgery: Incidence, Risk Factors, and Clinical Implications
This review synthesizes evidence comparing postoperative pulmonary complications (PPCs) between robot-assisted surgery (RAS) and conventional laparoscopic surgery (CLS) in abdominal procedures, highlighting the pivotal role of ventilation d
Targeting APOC3 with Olezarsen in Moderate Hypertriglyceridemia: Advances in Antisense Therapies for Triglyceride Reduction
Olezarsen, a GalNAc-conjugated antisense oligonucleotide targeting APOC3 mRNA, significantly reduces triglyceride levels in moderate hypertriglyceridemia, offering a promising therapeutic advance with favorable safety in cardiovascular risk
Balancing Risks and Benefits: Early Antipsychotic Dose Reduction Versus Maintenance After First-Episode Psychosis Remission
A randomized clinical trial reveals early dose reduction of antipsychotics after first-episode psychosis remission increases short-term relapse risk and lowers quality of life, but may improve long-term functioning over four years.
Memantine Shows Promise for Improving Social Impairment in Youths with Autism Spectrum Disorder
A 12-week randomized clinical trial demonstrates memantine’s efficacy and safety in improving social impairments in youths with ASD, with elevated pgACC glutamate levels serving as a predictive biomarker for treatment response.
Evaluating the Addition of Polymeric Micellar Paclitaxel to Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer: Insights from a Phase 3 Randomized Clinical Trial
A South Korean phase 3 trial found that adding polymeric micellar paclitaxel to gemcitabine and cisplatin did not improve survival for advanced biliary tract cancer, highlighting the challenges of intensified chemotherapy regimens.
Cost-Effectiveness of Mailed HPV Self-Testing Kits for Cervical Cancer Screening Across Diverse Screening Histories
Economic evaluation shows direct mailing of HPV self-sampling kits improves cervical cancer screening completion and is cost-effective among varied screening history groups in a US healthcare system, with budget benefits over time.
Bridging the Gap: Overcoming Barriers to Timely Melanoma Diagnosis and Treatment in Latino Patients
This article explores the facilitators and barriers Latino patients face in timely melanoma diagnosis and treatment, highlighting health insurance, linguistic challenges, and patient advocacy as key factors affecting outcomes.
Heart Rate Variability Biofeedback in Substance Use Disorder: Emerging Evidence from a Randomized Clinical Trial and Contextual Review
Second-generation heart rate variability biofeedback (HRVB) shows promise in reducing craving, negative affect, and substance use in adults with substance use disorder (SUD), supporting its potential as an adjunctive treatment in early reco
Sustained Cardiovascular Health in Young Adulthood Significantly Reduces Midlife Cardiovascular and Kidney Risks
A high cumulative cardiovascular health score from ages 30 to 40 correlates with substantially lower risks of cardiovascular and kidney events in midlife, underscoring the impact of early-life prevention strategies.
Non-β-Lactam Antibiotics, β-Lactam Allergy, and Surgical Site Infections: Implications for Prophylaxis and Stewardship
This study evaluates how reported β-lactam allergy and choice of prophylactic antibiotics impact surgical site infection rates, revealing non-β-lactam use increases SSI risk while allergy alone does not independently predict infections.
Unraveling the Link Between General Intelligence and Alcohol Use Disorder Risk
This article reviews emerging evidence on how general intelligence and cognitive performance relate to the risk of alcohol use disorder, integrating large-scale population data, genetic analyses, and the role of educational attainment acros
Deciphering the Role of Intratumoral Microbiota in Breast Cancer: Pathogenesis to Precision Therapeutics
Intratumoral microbiota significantly influence breast cancer development, progression, and therapeutic response. Their diverse composition across subtypes presents diagnostic and prognostic opportunities. Emerging strategies target these m
Novel Heparanase Inhibitor LMW-DSS Shows Promise in Preventing Breast Cancer Metastasis by Targeting Migration and Angiogenesis
Low-molecular-weight dextran sulfate sodium (LMW-DSS), a new heparanase inhibitor, effectively prevents breast cancer metastasis in mice by inhibiting cancer cell migration and angiogenesis, offering a promising therapeutic approach with mi
Advancing Immunotherapy in Head and Neck Cancer: A Curcumin-Based Polymer Prodrug Nanoplatform Targeting Cancer Stemness and Tumor Microenvironment
A novel curcumin-based polymer prodrug nanoplatform enhances immunotherapy in head and neck cancer by targeting tumor cell stemness and reversing immunosuppression via synergistic photothermal, photodynamic, and ferroptosis mechanisms.
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