OB/GYN & Women's Health
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Benzodiazepine Exposure and Adverse Pregnancy Outcomes: New Evidence from a Large-Scale Target Trial Emulation
A large-scale cohort study emulating randomized trials indicates that benzodiazepine use during pregnancy significantly increases the risk of abortion and preterm birth, even after accounting for competing risks and maternal factors. Risks

ICSI vs. Conventional IVF: New Evidence Suggests No Kinetic Advantage and Lower High-Quality Blastocyst Yield in Non-Male Factor Infertility
A secondary analysis of the multicentre INVICSI RCT reveals that ICSI results in fewer high-quality Day 5 blastocysts compared to conventional IVF in patients without severe male factor infertility, with no significant differences observed

Cervical Stromal Invasion Does Not Independently Predict Survival in Early-Stage Endometrial Cancer: A Multicenter Analysis
A large-scale multicenter study indicates that cervical stromal invasion is not an independent prognostic factor for survival in early-stage endometrial cancer, challenging traditional staging assumptions when other high-risk features are c

Thyroid Cancer Treatment in Adolescents and Young Adult Women: Impact on Reproductive Outcomes in a Population-Based Cohort
Thyroid cancer treatments in young women are linked to increased infertility diagnosis and early menopause but show no significant association with premature ovarian insufficiency or reduced childbirth rates.

Maternal Pre-existing Atherosclerotic Cardiovascular Disease: A Hidden Risk Factor for Neonatal Health and Long-term Neurodevelopment
A nationwide cohort study demonstrates that maternal pre-existing ASCVD is independently associated with an increased risk of neonatal complications and long-term neurodevelopmental disorders, persisting regardless of adverse pregnancy outc

Reducing False Positives in Mosaic Embryos Using Parental and Cell-Division Origin Analysis for Preimplantation Genetic Testing
This study introduces a novel method using parental and cell-division origin analysis to reduce false-positive mosaic embryo diagnoses in preimplantation genetic testing, improving embryo selection and transfer outcomes.

Rethinking Mosaicism: Why Reporting Putative Mosaic Embryos Fails to Improve IVF Outcomes
A large, double-blinded study reveals that reporting embryo mosaicism (ICN) during PGT-A provides no meaningful clinical predictive value for live birth rates, suggesting that current classification systems may unnecessarily limit embryo se

Redefining Pelvic Pain: A Validated Diagnostic Threshold for High Tone Pelvic Floor Dysfunction
A landmark study establishes a data-driven diagnostic threshold for high tone pelvic floor dysfunction (HTPFD), identifying a summative tenderness score of >12/60 as a key clinical marker associated with persistent pain, activity-induced ex

Vaginal Hysterectomy is No Longer the Uncontested Gold Standard: Evidence from a National 10-Year Analysis
A large-scale analysis of over 83,000 cases reveals that laparoscopic hysterectomy may offer lower complication rates and shorter hospital stays than vaginal hysterectomy, prompting a re-evaluation of current surgical guidelines for benign

Beyond Patient Factors: Modifying Surgical Practice to Mitigate Racial Disparities in Benign Hysterectomy
This study identifies key modifiable surgical and hospital-level factors—including surgical approach and antibiotic adherence—that contribute to the disproportionately higher rate of postoperative complications experienced by Black patients

Long COVID-19 in Pregnancy: Elevated Risk Amidst Mild Omicron Infection in a Boosted Vaccinated Cohort During COVID-19 Endemicity
Pregnant women show increased risk of long COVID-19 post-SARS-CoV-2 infection during Omicron predominance despite mild disease, yet incidence remains modest in a highly vaccinated cohort, highlighting vaccination’s protective role amidst em

The Role of COVID-19 Vaccination in Improving Maternal and Perinatal Outcomes: A Comprehensive Review
Vaccination against SARS-CoV-2 during pregnancy significantly lowers risks of severe maternal COVID-19, hospitalization, critical care admission, and preterm birth across variant periods, underscoring its safety and efficacy for maternal an

Systemic Sclerosis Pregnancies: High Livebirth Rates Mask Significant Risks of Placental Insufficiency and Postpartum Disease Progression
The French GR2 prospective study reveals that while 91% of pregnancies in systemic sclerosis result in livebirths, patients face significantly higher risks of pre-eclampsia, fetal growth restriction, and severe postpartum hemorrhage, with n

Progestagens Show Moderate Efficacy for Endometriosis Pain, But Evidence Variability Limits Clinical Certainty
Oral progestagens reduce overall pain and dysmenorrhoea in endometriosis, but comparative benefits over other hormonal therapies remain uncertain.

Simple vs Radical Hysterectomy: Balancing Survival Outcomes and Quality of Life in Early Cervical Cancer
Evidence suggests simple hysterectomy with pelvic lymphadenectomy may offer similar survival outcomes to radical hysterectomy in early-stage cervical cancer, with fewer adverse events and better short-term quality of life.

Immediate and Early Skin-to-Skin Contact After Birth: What the 2025 Cochrane Update Means for Practice
A clear, evidence-based summary of the 2025 Cochrane review on immediate/early skin-to-skin contact (SSC), its impact on breastfeeding and newborn physiology, gaps in maternal outcomes, and practical recommendations for clinical implementat

Breast Surgery in Metastatic Breast Cancer: Local Control Without Survival Benefit
Randomised trials show breast surgery improves local disease control but not overall survival in de novo metastatic breast cancer.

HPV Vaccination Significantly Reduces Precancerous Lesions and Anogenital Warts: Evidence from a Network Meta‑Analysis
A large network meta‑analysis confirms HPV vaccines effectively reduce CIN2+ and anogenital warts, with no major safety concerns.

Calcium Supplementation During Pregnancy for Preventing Hypertensive Disorders: Current Evidence and Clinical Implications
This review synthesizes recent randomized controlled trials and meta-analyses on calcium supplementation during pregnancy, evaluating its effectiveness in preventing hypertensive disorders such as pre-eclampsia and related maternal and neon

Enhancing Access to Mifepristone via Community Pharmacies: Evidence from Routine Prescription Regulation in British Columbia, Canada
This review synthesizes data on mifepristone availability at community pharmacies in BC, highlighting geographic coverage, dispensing gaps, and disparities influencing timely access to medication abortion.
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