Family History as a Dose-Dependent Risk Factor for Postpartum Venous Thromboembolism: Insights from a Nationwide Swedish Cohort Study
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This nationwide Swedish cohort study examined over 850,000 first-time mothers and found that a family history of venous thromboembolism (VTE) strongly influences the risk of postpartum VTE. Risk increases with closer genetic relatedness and the number of affected relatives, demonstrating a clear dose-response relationship. Other clinical factors such as obesity, autoimmune disease, and obstetric complications also independently elevate risk.
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