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This large pooled case-control study from the Multi-National Subpopulations Study to Evaluate Rotavirus Vaccines (MNSSTER-V) dataset shows that rotavirus vaccination provides 75.8% effectiveness against rotavirus-positive acute gastroenteritis mortality in children under five. Despite a smaller, non-significant reduction against all-cause acute gastroenteritis deaths, these findings highlight the critical importance of rotavirus vaccines in global child health. Continuous efforts to improve vaccine coverage could substantially reduce diarrhoeal deaths worldwide.
