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A large-scale multinational study of over 1.2 million patients reveals that individual GLP-1 receptor agonists and SGLT2 inhibitors offer broadly similar cardiovascular protection in type 2 diabetes, challenging assumptions about meaningful
Researchers have identified a genetic variant in the cubilin gene (CUBN, rs1801222) that significantly increases the risk of metformin-induced vitamin B12 deficiency, with carriers of the AA genotype experiencing deficiency up to twice as f
A 16-week home-based trial combining testosterone with functional electrical stimulation and arm ergometry improved lean mass and corrected anemia in spinal cord injury patients, though aerobic capacity gains were not statistically signific
A nationwide cohort study of 466,462 infants reveals that maternal pregestational diabetes significantly increases the risk of delayed developmental milestones, with type 1 diabetes conferring the highest risk and female offspring showing p
A prospective study identifies exhaustion, head and neck discomfort, and body image concerns as independent predictors of poor emotional functioning in differentiated thyroid carcinoma patients. These findings highlight actionable targets f
A landmark population-based study spanning 2006-2020 in Stockholm, Sweden, reveals that biochemically confirmed primary hyperparathyroidism incidence increased by 52% while only half of affected patients received clinical diagnosis, highlig
A multicenter retrospective cohort study reveals that metabolic bariatric surgery in 162 adults with type 1 diabetes and obesity achieved 29.7% weight loss at one year, reduced insulin requirements by 57%, and significantly improved glycemi
A landmark Swedish cohort study of 95,490 patients reveals that semaglutide is associated with a 42% lower risk of worsening mental illness in people with depression and anxiety, while other GLP-1 receptor agonists show varied effects. The
A retrospective cohort study of 524,687 diabetic patients reveals that increasing severity of diabetic retinopathy correlates with significantly higher mortality risk, with proliferative DR patients showing a 128% increased hazard of death
A randomized trial of 205 pregnant women with gestational diabetes found that adjunctive flash glucose monitoring did not improve time-in-range glucose measurements compared to standard self-monitoring. However, the device was associated wi
A randomized crossover trial demonstrates that a dairy-enriched diet with high-protein breakfast and early daytime carbohydrate restriction significantly upregulates circadian clock genes (BMAL1, REV-ERBα, CRY1), improves glycemic metrics i
A 3-year prospective study demonstrates sustained biochemical and clinical improvements with burosumab in XLH patients across pediatric and adult age groups, including those typically excluded from clinical trials.
A retrospective study of 452 diabetic foot ulcer patients found that SGLT2 inhibitor use was not associated with increased amputation risk at 1 year and was linked to significantly lower mortality (1.1% vs 9.2%) and faster wound healing (44
A 14-year cohort study of 3,079 individuals with type 1 diabetes reveals that visit-to-visit blood pressure variability, particularly systolic blood pressure variability measured by average real variability, significantly predicts diabetic
Novel OCTA biomarkers reveal that geometric perfusion deficits in the deep capillary plexus serve as robust predictors of retinal nonperfusion across posterior, peripheral, and total retinal regions, while foveal avascular zone enlargement
This review synthesizes recent evidence regarding the association between semaglutide initiation and nonarteritic anterior ischemic optic neuropathy (NAION), contrasting high-risk findings in real-world cohort studies with neutral findings
In pediatric autoimmune hyperthyroidism, a higher FT3/FT4 ratio predicted relapse after antithyroid drug withdrawal, especially when orbitopathy was present.
This review synthesizes evidence on the genetic architecture of adult-onset diabetes subtypes, highlighting that Moderate Obesity-related Diabetes (MOD) is uniquely and causally linked to coronary artery disease risk through polygenic and M
In Finnish adults with type 1 diabetes, STEMI and NSTEMI showed distinct incidence trends and risk profiles. NSTEMI was more common overall and linked to dyslipidemia and advanced microvascular disease, whereas impaired eGFR tracked more wi
This review synthesizes the 54-month results of the ATTRibute-CM open-label extension, demonstrating that early and continuous acoramidis treatment provides sustained reductions in mortality and cardiovascular hospitalizations while maintai
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