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An epigenome-wide study reveals that DNA methylation markers linked to inflammatory pathways and blood lipid traits play a causal role in abdominal aortic aneurysm development, offering potential for improved risk prediction and therapeutic
This study reveals distinct histopathologic features in chronic rhinosinusitis patients with intranasal substance use, highlighting increased neutrophilic inflammation and epithelial remodeling, underscoring the need for targeted clinical a
This study demonstrates that urinary aldosterone measurement by LC-MS/MS outperforms immunoassay in diagnosing primary aldosteronism, especially when urinary sodium is within an optimal range, offering improved sensitivity and specificity f
Spatial multimodal profiling reveals two macrophage-defined ENKTL subgroups with distinct tumor-myeloid interactions influencing prognosis and potential immunotherapy targets.
Elevated plasma pro-opiomelanocortin (POMC) levels accurately predict silent corticotroph adenomas (SCAs) among clinically non-functioning pituitary adenomas, offering a promising tool for diagnosis and monitoring.
Persistent high-risk HPV infection with normal or low-grade cytology carries a significant risk of high-grade cervical lesions, especially in younger women and those with atypical cytology. Colposcopy shows low sensitivity, urging careful b
This study investigates whether contained manual morcellation during minimally invasive hysterectomy prevents myometrial cell spillage by analyzing sequential pelvic washings, revealing low spillage mostly occurring before morcellation.
Multisociety 2026 guidance clarifies diagnosis and management of atypical breast lesions and lobular carcinoma in situ, balancing excision, surveillance, and chemoprevention based on lesion type, radiologic concordance, and risk.
This prospective multicenter study demonstrates that cfDNA fetal risk screening accurately identifies autosomal recessive conditions in general-risk pregnancies with high specificity and improved positive predictive value compared to tradit
Spatial remodeling of bone marrow in myelodysplastic neoplasms (MDS) reveals distinctive tissue-state signatures that better capture disease activity and predict therapeutic response beyond traditional blast counts.
A multiprotein plasma panel improves detection of advanced neocortical tau pathology in Alzheimer’s disease risk individuals beyond p-tau217 alone, enhancing patient stratification and clinical trial selection.
The ADAM Study demonstrates superior diagnostic accuracy of live cell-based assays over fixed cell-based and ELISA tests for detecting AChR antibodies in myasthenia gravis, highlighting important clinical implications for antibody testing s
The ADAM study reveals that live and fixed cell-based assays outperform ELISA in detecting AChR and MuSK antibodies, offering enhanced diagnostic accuracy for myasthenia gravis, particularly in ocular cases.
This study analyzes clinicopathological and genetic correlations in Parkinsonian disorders across diverse ancestries, revealing diagnostic challenges, genetic influences, and ancestry-related pathological variations.
This study reveals that two-thirds of community sudden cardiac deaths occur in individuals without diagnosed cardiac disease, with half harboring occult myocardial infarction or dilated cardiomyopathy, underscoring the need for improved det
This cohort study assesses the sensitivity and clinical relevance of dried blood spot PCR testing for congenital CMV in infants identified through expanded targeted screening, highlighting diagnostic strengths and limitations for universal
A practical summary of a 2026 multidisciplinary consensus on the proper evaluation and workup of sinonasal masses, emphasizing when to image, when to biopsy, pathology needs, and special-population considerations.
This study identifies distinct placental pathology risks across ultrasound-defined fetal growth phenotypes in dichorionic twins, proposing risk categories to guide clinical management and future research on late-onset fetal growth restricti
This study introduces and validates a simplified machine learning-based equation for estimating LDL cholesterol, showing comparable accuracy to the original Martin-Hopkins method and improved ease of use.
Plasma phosphorylated tau biomarkers overlap in Alzheimer’s and prion diseases, risking diagnostic confusion. The NfL/p-tau217 ratio emerges as an accurate plasma biomarker to distinguish prion diseases from Alzheimer’s, improving diagnosti
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