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This large international cohort study clarifies the clinical course, management strategies, and outcomes of ectopic Cushing syndrome, highlighting early biochemical remission as crucial for reducing mortality and complications.
In patients with suspected obstructive sleep apnea, increased respiratory effort measured by negative esophageal pressure during sleep independently predicts long-term mortality beyond traditional markers, underscoring its clinical importan
Anticoagulation therapy in adults aged 80 and older with atrial fibrillation is linked to reduced all-cause mortality despite an increased risk of gastrointestinal bleeding, supporting its continued use in selected elderly patients.
This randomized trial compared intermittent hemodialysis and continuous renal-replacement therapy in critically ill AKI patients and found that continuous therapy was associated with lower 90-day mortality and similar kidney outcomes.
New evidence suggests lower urine output thresholds than current standards better predict acute kidney injury, chronic kidney disease, and mortality in critically ill patients, urging redefinition of oliguria parameters in AKI diagnostics.
This study reveals that various combinations of daily step counts and stepping intensity independently reduce all-cause and cardiovascular mortality, highlighting the importance of personalized physical activity strategies.
This study reveals that lower and declining social integration significantly increase long-term mortality risk after traumatic spinal cord injury, highlighting critical social determinants alongside clinical factors.
This study reveals how diabetes and ASCVD alter the link between soluble TNF receptor 1 levels and 90-day sepsis mortality, informing biomarker-guided risk assessment and understanding of sepsis pathobiology.
Postoperative pneumothorax after thyroid or parathyroid surgery is uncommon but linked with significantly increased mortality and complications, underscoring the need for vigilance and prompt management.
A large cohort study highlights how acquired cardiovascular risk factors significantly influence late mortality in adults with congenital heart disease, underscoring the need for integrated care strategies.
White blood cell count modifies mortality outcomes in sepsis patients treated with cefepime versus piperacillin-tazobactam, suggesting its potential role in guiding antibiotic selection.
This comprehensive 10-year ICU study reveals a low prevalence of positive pleural fluid cultures, highlights the significant link to suspected pleural infection, and associates culture positivity with higher 90-day mortality, informing targ
Younger age at type 1 diabetes diagnosis significantly increases risks of mortality, cardiovascular, and kidney complications; each additional year delay in onset reduces these risks. This review synthesizes nationwide cohort findings and c
A large multicenter study shows that balanced crystalloids administered before ICU admission in sepsis patients reduce 30-day mortality compared to saline, supporting early fluid choice’s impact on sepsis outcomes.
This review analyzes the impact of age and anthracycline-based chemotherapy on mortality in 28,000 classic Hodgkin lymphoma patients, highlighting poorer outcomes in the elderly and the therapeutic nuances influencing survival.
This review synthesizes evidence on how hospitals’ prevalence of transfer-in patients relates to risk-adjusted mortality, length of stay, and charges, highlighting complex interplay between patient case mix and hospital performance me
Higher hospital cardiac capability correlates with lower mortality in cardiogenic shock patients, and regionalized hub-and-spoke models mitigate the transfer penalty associated with patient instability.
This large-scale England study reveals persistently high mortality after below-knee amputation in diabetes, with one-year mortality exceeding 23%, emphasizing the need for targeted interventions focused on older, female, and comorbid patien
A UK prospective cohort study reveals a U-shaped association between hemoglobin concentration and mortality, with both low and high levels linked to increased death risk across age and sex groups.
A global study identifies key hospital-level modifiable resources that reduce 90-day mortality after pancreas surgery and introduces a composite Hospital Resource Index to guide improvements beyond surgical volume centralization.
